{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:37:47Z","timestamp":1792024667958,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.pupt.2023.102261","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T17:33:24Z","timestamp":1695663204000},"page":"102261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The impact of nintedanib and pirfenidone on lung function and survival in patients with idiopathic pulmonary fibrosis in real-life setting"],"prefix":"10.1016","volume":"83","author":[{"given":"Gabriela","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Fabiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Caetano","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lder","family":"Novais-Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Terras","family":"Alexandre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concei\u00e7\u00e3o Souto","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pupt.2023.102261_bib1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1183\/23120541.00187-2020","article-title":"Idiopathic pulmonary fibrosis in the UK: analysis of the British Thoracic Society electronic registry between 2013 and 2019","volume":"7","author":"Spencer","year":"2021","journal-title":"ERJ Open Res"},{"issue":"2","key":"10.1016\/j.pupt.2023.102261_bib2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S2213-2600(17)30433-2","article-title":"Review diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper","volume":"6","author":"Lynch","year":"2018","journal-title":"Lancet Respir"},{"issue":"32","key":"10.1016\/j.pupt.2023.102261_bib3","first-page":"1","article-title":"Idiopathic pulmonary fibrosis: pathogenesis and management","volume":"19","author":"Sgalla","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.pupt.2023.102261_bib4","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1056\/NEJMoa1113354","article-title":"Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibroses","volume":"366","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"22","key":"10.1016\/j.pupt.2023.102261_bib5","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa1402584","article-title":"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis","volume":"370","author":"Brown","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pupt.2023.102261_bib6","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"370","author":"Glaspole","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.pupt.2023.102261_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1164\/rccm.201902-0456OC","article-title":"Clinical effectiveness of antifibrotic medications for idiopathic pulmonary fibrosis","volume":"200","author":"Dempsey","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2023.102261_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1164\/rccm.201506-1063ST","article-title":"An official ATS\/ERS\/JRS\/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis - an update of the 2011 clinical practice guideline","volume":"192","author":"Raghu","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.pupt.2023.102261_bib9","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of idiopathic pulmonary fibrosis","volume":"198","author":"Raghu","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.pupt.2023.102261_bib10","first-page":"112","article-title":"Consensus document for the diagnosis and treatment of idiopathic pulmonary fibrosis Joint Consensus of Sociedade Portuguesa de Pneumologia , Sociedade Portuguesa de Radiologia e Medicina Nuclear e Sociedade Portuguesa de Anatomia","volume":"22","author":"Cordeiro","year":"2016","journal-title":"Rev. Port. Pneumol."},{"issue":"1600016","key":"10.1016\/j.pupt.2023.102261_bib11","first-page":"1","article-title":"ERS\/ATS standards for single-breath carbon monoxide uptake in the lung","volume":"49","author":"Graham","year":"2017","journal-title":"Eur. Respir. J."},{"issue":"8","key":"10.1016\/j.pupt.2023.102261_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of spirometry 2019 update - an official American thoracic society and European respiratory society technical statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.pupt.2023.102261_bib13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1183\/09031936.93.02060561","article-title":"Technical recommendations and guidelines for bronchoalveolar lavage (BAL). Report of the European society of pneumology task group. PMID: 2663535","volume":"2","author":"Klech","year":"1989","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.pupt.2023.102261_bib14","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.chest.2019.10.048","article-title":"Transbronchial cryobiopsy for the diagnosis of interstitial lung diseases: CHEST guideline and expert panel report","volume":"157","author":"Maldonado","year":"2020","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.pupt.2023.102261_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.rppneu.2012.05.002","article-title":"Fibrose pulmonar idiop\u00e1tica: apresenta\u00e7\u00e3o cl\u00ednica, evolu\u00e7\u00e3o e fatores de progn\u00f3stico basais numa coorte portuguesa","volume":"19","author":"Pires","year":"2013","journal-title":"Rev Port Pneumol Pneumol"},{"key":"10.1016\/j.pupt.2023.102261_bib16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis : evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"November 2020","key":"10.1016\/j.pupt.2023.102261_bib17","first-page":"1","article-title":"Insights on chronic hypersensitivity pneumonitis' treatment: factors associated with a favourable response to azathioprine","volume":"272","author":"Raimundo","year":"2021","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.pupt.2023.102261_bib18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pulmoe.2019.09.004","article-title":"Hypersensitivity pneumonitis : main features characterization in a Portuguese cohort","volume":"26","author":"Santos","year":"2020","journal-title":"Pulmonology"},{"issue":"9","key":"10.1016\/j.pupt.2023.102261_bib19","first-page":"1","article-title":"Survival and lung function decline in patients with definite, probable and possible idiopathic pulmonary fibrosis treated with pirfenidone","volume":"17","author":"Id","year":"2022","journal-title":"PLoS One"},{"issue":"September","key":"10.1016\/j.pupt.2023.102261_bib20","first-page":"1","article-title":"Long-term follow-up of patients with idiopathic pulmonary fibrosis treated with pirfenidone or nintedanib: a real-life comparison study","volume":"7","author":"Cameli","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"268","key":"10.1016\/j.pupt.2023.102261_bib21","first-page":"1","article-title":"Pirfenidone vs. nintedanib in patients with idiopathic pulmonary fibrosis: a retrospective cohort study","volume":"22","author":"Marijic","year":"2021","journal-title":"Respir Res [Internet]"},{"issue":"9779","key":"10.1016\/j.pupt.2023.102261_bib22","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/S0140-6736(11)60405-4","article-title":"Pirfenidone in patients with idiopathic pulmonary fi brosis (CAPACITY): two randomised trials","volume":"377","author":"Noble","year":"2011","journal-title":"Lancet"},{"issue":"105","key":"10.1016\/j.pupt.2023.102261_bib23","first-page":"1","article-title":"Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis : insights from the IPF-PRO Registry","volume":"20","author":"Snyder","year":"2019","journal-title":"Respir. Res."},{"issue":"135","key":"10.1016\/j.pupt.2023.102261_bib24","first-page":"1","article-title":"Comparative outcomes in patients receiving pirfenidone or nintedanib for idiopathic pulmonary fibrosis","volume":"22","author":"Belhassen","year":"2021","journal-title":"Respir Res [Internet]"},{"key":"10.1016\/j.pupt.2023.102261_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s12325-020-01523-7","article-title":"Real-world study analysing progression and survival of patients with idiopathic pulmonary fibrosis with preserved lung function on antifibrotic treatment","volume":"38","author":"Noor","year":"2021","journal-title":"Adv. Ther."},{"issue":"177","key":"10.1016\/j.pupt.2023.102261_bib26","first-page":"1","article-title":"Pirfenidone improves survival in IPF: results from a real-life study","volume":"18","author":"Margaritopoulos","year":"2018","journal-title":"BMC Pulm. Med."},{"issue":"135","key":"10.1016\/j.pupt.2023.102261_bib27","first-page":"1","article-title":"Comorbidity burden and survival in patients with idiopathic pulmonary fibrosis: the EMPIRE registry study","volume":"23","author":"Jovanovic","year":"2022","journal-title":"Respir. Med."},{"issue":"1902279","key":"10.1016\/j.pupt.2023.102261_bib28","article-title":"Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis : long-term results of the INSIGHTS-IPF registry","volume":"56","author":"Behr","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pupt.2023.102261_bib29","first-page":"267","article-title":"The predictors of mortality in IPF - does emphysema change the prognosis?","volume":"33","author":"Aky\u0131l","year":"2016","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"issue":"3828","key":"10.1016\/j.pupt.2023.102261_bib30","first-page":"1","article-title":"Predictors of mortality in patients with interstitial lung disease-associated pulmonary hypertension","volume":"9","author":"Alhamad","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pupt.2023.102261_bib31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1164\/rccm.200611-1696OC","article-title":"Computed tomography findings in pathological usual interstitial pneumonia relationship to survival","volume":"177","author":"Sumikawa","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2023.102261_bib32","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1164\/rccm.200412-1756OC","article-title":"High-resolution computed tomography in idiopathic pulmonary fibrosis diagnosis and prognosis","volume":"172","author":"Lynch","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pupt.2023.102261_bib33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1164\/rccm.201006-0894CI","article-title":"Concise clinical review clinical course and prediction of survival in idiopathic pulmonary fibrosis","volume":"183","author":"Ley","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1701603","key":"10.1016\/j.pupt.2023.102261_bib34","first-page":"51","article-title":"Trends in mortality from idiopathic pulmonary fibrosis in the European Union: an observational study of the WHO mortality database from 2001 \u2013 2013","author":"Marshall","year":"2018","journal-title":"Eur. Respir. J."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553923000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553923000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:32:06Z","timestamp":1761082326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553923000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":34,"alternative-id":["S1094553923000731"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2023.102261","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of nintedanib and pirfenidone on lung function and survival in patients with idiopathic pulmonary fibrosis in real-life setting","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2023.102261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102261"}}