{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:38:18Z","timestamp":1785839898198,"version":"3.56.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.pupt.2024.102317","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T23:30:17Z","timestamp":1723851017000},"page":"102317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["FTO promotes gefitinib-resistance by enhancing PELI3 expression and autophagy in non-small cell lung cancer"],"prefix":"10.1016","volume":"87","author":[{"given":"Yu-Zheng","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Hua","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Nian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Lei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Jie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pupt.2024.102317_bib1","first-page":"45","article-title":"Epidemiology of lung cancer","volume":"25","author":"Thandra","year":"2021","journal-title":"Contemp. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10147-021-02108-2","article-title":"Mapping of global, regional and national incidence, mortality and mortality-to-incidence ratio of lung cancer in 2020 and 2050","volume":"27","author":"Sharma","year":"2022","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jtho.2021.11.003","article-title":"The 2021 WHO classification of lung tumors: impact of advances since 2015","volume":"17","author":"Nicholson","year":"2022","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1515\/med-2020-0028","article-title":"Classification of pathological types of lung cancer from CT images by deep residual neural networks with transfer learning strategy","volume":"15","author":"Wang","year":"2020","journal-title":"Open Med."},{"key":"10.1016\/j.pupt.2024.102317_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00408-020-00407-5","article-title":"Update 2020: management of non-small cell lung cancer","volume":"198","author":"Alexander","year":"2020","journal-title":"Lung"},{"key":"10.1016\/j.pupt.2024.102317_bib6","article-title":"Current treatments for non-small cell lung cancer","volume":"12","author":"Guo","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib7","doi-asserted-by":"crossref","first-page":"s41","DOI":"10.7861\/clinmedicine.18-2-s41","article-title":"Recent advances in the management of lung cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Clin. Med."},{"key":"10.1016\/j.pupt.2024.102317_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14071614","article-title":"Molecular mechanisms of cancer drug resistance: emerging biomarkers and promising targets to overcome tumor progression","volume":"14","author":"Fontana","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.pupt.2024.102317_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.891652","article-title":"Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches","volume":"12","author":"Emran","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib10","first-page":"141","article-title":"Drug resistance and combating drug resistance in cancer","volume":"2","author":"Wang","year":"2019","journal-title":"Cancer Drug Resist"},{"key":"10.1016\/j.pupt.2024.102317_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2024.102317_bib12","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1093\/nar\/gkaa347","article-title":"Dynamic landscape and evolution of m6A methylation in human","volume":"48","author":"Zhang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.pupt.2024.102317_bib13","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106434","article-title":"m(6) A-mediated alternative splicing coupled with nonsense-mediated mRNA decay regulates SAM synthetase homeostasis","volume":"40","author":"Watabe","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.pupt.2024.102317_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bbagrm.2018.10.006","article-title":"m(6)A-mediated translation regulation","volume":"1862","author":"Meyer","year":"2019","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"10.1016\/j.pupt.2024.102317_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pupt.2024.102317_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/1878-0261.13326","article-title":"RNA m(6) A methylation in cancer","volume":"17","author":"Wang","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib17","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1080\/21655979.2021.2001936","article-title":"Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R)","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.pupt.2024.102317_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073800","article-title":"FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms","volume":"23","author":"Azzam","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pupt.2024.102317_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13578-022-00798-3","article-title":"m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer","volume":"12","author":"Duan","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.pupt.2024.102317_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gendis.2021.01.005","article-title":"Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: implications in lipid metabolic disorders","volume":"9","author":"Yang","year":"2022","journal-title":"Genes Dis"},{"key":"10.1016\/j.pupt.2024.102317_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/15476286.2021.2016203","article-title":"The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells","volume":"19","author":"Relier","year":"2022","journal-title":"RNA Biol."},{"key":"10.1016\/j.pupt.2024.102317_bib22","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.gendis.2020.07.011","article-title":"The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases","volume":"8","author":"Zhang","year":"2021","journal-title":"Genes Dis"},{"key":"10.1016\/j.pupt.2024.102317_bib23","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.29271\/jcpsp.2022.09.1143","article-title":"m(6)A RNA, FTO, ALKBH5 expression in type 2 diabetic and obesity patients","volume":"32","author":"Onalan","year":"2022","journal-title":"J Coll Physicians Surg Pak"},{"key":"10.1016\/j.pupt.2024.102317_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.pupt.2024.102317_bib25","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1158\/0008-5472.CAN-19-4044","article-title":"FTO-dependent N (6)-methyladenosine modifications inhibit ovarian cancer stem cell self-renewal by blocking cAMP signaling","volume":"80","author":"Huang","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.pupt.2024.102317_bib26","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.2147\/OTT.S329232","article-title":"Roles of N6-methyladenosine demethylase FTO in malignant tumors progression","volume":"14","author":"Zheng","year":"2021","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.pupt.2024.102317_bib27","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.2147\/OTT.S283417","article-title":"The potential role of N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene (FTO) in human cancers","volume":"13","author":"Wang","year":"2020","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.pupt.2024.102317_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","article-title":"FTO plays an oncogenic role in acute myeloid leukemia as a N(6)-methyladenosine RNA demethylase","volume":"31","author":"Li","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pupt.2024.102317_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6668463","article-title":"Ligase Pellino3 regulates macrophage action and survival in response to VSV infection in RIG-I-dependent path","volume":"2021","author":"Reniewicz","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.pupt.2024.102317_bib30","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.2429","article-title":"Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons","volume":"13","author":"Siednienko","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.pupt.2024.102317_bib31","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.4161\/auto.32178","article-title":"Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression","volume":"10","author":"Giegerich","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.pupt.2024.102317_bib32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/cr.2016.40","article-title":"Ubiquitin signaling in immune responses","volume":"26","author":"Hu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.pupt.2024.102317_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2011.60","article-title":"Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance","volume":"9","author":"Jin","year":"2012","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.pupt.2024.102317_bib34","article-title":"The emerging roles of Pellino family in pattern recognition receptor signaling","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pupt.2024.102317_bib35","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tig.2021.05.002","article-title":"Navigating the DNA methylation landscape of cancer","volume":"37","author":"Nishiyama","year":"2021","journal-title":"Trends Genet."},{"key":"10.1016\/j.pupt.2024.102317_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/PPO.0000000000000279","article-title":"The roles of DNA methylation in the stages of cancer","volume":"23","author":"McMahon","year":"2017","journal-title":"Cancer J."},{"key":"10.1016\/j.pupt.2024.102317_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/2211-5463.12765","article-title":"Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer","volume":"10","author":"Ohmura","year":"2020","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.pupt.2024.102317_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41392-023-01341-7","article-title":"Targeting epigenetic regulators to overcome drug resistance in cancers","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.pupt.2024.102317_bib39","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.3389\/fonc.2020.01152","article-title":"Role of DNA methylation in the resistance to therapy in solid tumors","volume":"10","author":"Romero-Garcia","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib40","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.bpj.2012.03.056","article-title":"Impact of methylation on the physical properties of DNA","volume":"102","author":"Perez","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.pupt.2024.102317_bib41","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1042\/EBC20190033","article-title":"Sensitivity of transcription factors to DNA methylation","volume":"63","author":"Heberle","year":"2019","journal-title":"Essays Biochem."},{"key":"10.1016\/j.pupt.2024.102317_bib42","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.aar7854","article-title":"A DNA methylation reader complex that enhances gene transcription","volume":"362","author":"Harris","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pupt.2024.102317_bib43","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.pupt.2024.102317_bib44","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.gendis.2022.04.014","article-title":"Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases","volume":"10","author":"Huang","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.pupt.2024.102317_bib45","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tig.2010.02.006","article-title":"The genetics of obesity: FTO leads the way","volume":"26","author":"Fawcett","year":"2010","journal-title":"Trends Genet."},{"key":"10.1016\/j.pupt.2024.102317_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.617172","article-title":"RNA demethylase FTO mediated RNA m(6)A modification is involved in maintaining maternal-fetal interface in spontaneous abortion","volume":"9","author":"Qiu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.pupt.2024.102317_bib47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/toxsci\/kfy172","article-title":"m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite","volume":"165","author":"Bai","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.pupt.2024.102317_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/521381","article-title":"Role of FTO in adipocyte development and function: recent insights","volume":"2015","author":"Merkestein","year":"2015","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.pupt.2024.102317_bib49","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1038\/s41467-019-10669-0","article-title":"m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pupt.2024.102317_bib50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-019-1004-4","article-title":"RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3","volume":"18","author":"Niu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.pupt.2024.102317_bib51","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2147\/OTT.S231914","article-title":"FTO facilitates lung adenocarcinoma cell progression by activating cell migration through mRNA demethylation","volume":"13","author":"Ding","year":"2020","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.pupt.2024.102317_bib52","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bbrc.2018.05.175","article-title":"m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression","volume":"502","author":"Liu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.pupt.2024.102317_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccell.2020.04.017","article-title":"Targeting FTO suppresses cancer stem cell maintenance and immune evasion","volume":"38","author":"Su","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pupt.2024.102317_bib54","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1038\/s41467-021-21758-4","article-title":"FTO-mediated cytoplasmic m(6)A(m) demethylation adjusts stem-like properties in colorectal cancer cell","volume":"12","author":"Relier","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pupt.2024.102317_bib55","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1158\/0008-5472.CAN-20-0132","article-title":"FTO inhibition enhances the antitumor effect of temozolomide by targeting MYC-miR-155\/23a cluster-MXI1 feedback circuit in glioma","volume":"80","author":"Xiao","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.pupt.2024.102317_bib56","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.apsb.2021.08.028","article-title":"A novel inhibitor of N (6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities","volume":"12","author":"Xie","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.pupt.2024.102317_bib57","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2217\/pgs-2020-0006","article-title":"miR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3","volume":"21","author":"Li","year":"2020","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.pupt.2024.102317_bib58","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40659-019-0230-y","article-title":"PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer","volume":"52","author":"He","year":"2019","journal-title":"Biol. Res."},{"key":"10.1016\/j.pupt.2024.102317_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113466","article-title":"The roles of autophagy in cancer","volume":"19","author":"Yun","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.pupt.2024.102317_bib60","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13578-021-00570-z","article-title":"Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect","volume":"11","author":"Lim","year":"2021","journal-title":"Cell Biosci."},{"key":"10.1016\/j.pupt.2024.102317_bib61","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13045-020-01000-2","article-title":"Targeting autophagy to overcome drug resistance: further developments","volume":"13","author":"Chang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.621428","article-title":"The role of autophagy in gastric cancer chemoresistance: friend or foe?","volume":"8","author":"Xu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.pupt.2024.102317_bib63","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13046-022-02293-6","article-title":"Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response","volume":"41","author":"Ashrafizadeh","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.pupt.2024.102317_bib64","doi-asserted-by":"crossref","first-page":"83476","DOI":"10.18632\/oncotarget.13080","article-title":"Autophagy as an emerging therapy target for ovarian carcinoma","volume":"7","author":"Zhan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.pupt.2024.102317_bib65","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12964-023-01053-z","article-title":"Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches","volume":"21","author":"Hashemi","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.pupt.2024.102317_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.924290","article-title":"Autophagy: a versatile player in the progression of colorectal cancer and drug resistance","volume":"12","author":"Manzoor","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.pupt.2024.102317_bib67","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3892\/mco.2022.2505","article-title":"Role of autophagy in drug resistance and regulation of osteosarcoma","volume":"16","author":"Pu","year":"2022","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.pupt.2024.102317_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.578418","article-title":"The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity","volume":"10","author":"Chavez-Dominguez","year":"2020","journal-title":"Front. Oncol"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553924000336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553924000336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T21:30:08Z","timestamp":1733866208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553924000336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":68,"alternative-id":["S1094553924000336"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2024.102317","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FTO promotes gefitinib-resistance by enhancing PELI3 expression and autophagy in non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2024.102317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102317"}}