{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:01:38Z","timestamp":1782586898469,"version":"3.54.5"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.pupt.2026.102409","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:21:19Z","timestamp":1768868479000},"page":"102409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Echocardiographic effects of dupilumab in patients with severe type 2 asthma"],"prefix":"10.1016","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-7367","authenticated-orcid":false,"given":"Corrado","family":"Pelaia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Armentaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lupia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Giacalone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Miceli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Pastura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giandomenico","family":"Severini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Fuoco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Panza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Capilupi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosangela","family":"Scarcelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Lucia","family":"Piazzetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Chiarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Vatrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girolamo","family":"Pelaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sciacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.pupt.2026.102409_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding asthma phenotypes, endotypes, and mechanisms of disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"7","key":"10.1016\/j.pupt.2026.102409_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/17476348.2024.2380072","article-title":"Type 2 severe asthma: pathophysiology and treatment with biologics","volume":"18","author":"Pelaia","year":"2024","journal-title":"Expet Rev. Respir. Med."},{"key":"10.1016\/j.pupt.2026.102409_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1354556","article-title":"The last step to achieve barrier damage control","volume":"15","author":"Baglivo","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pupt.2026.102409_bib4","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3389\/fphys.2019.01514","article-title":"Interleukin-5 in the pathophysiology of severe asthma","volume":"10","author":"Pelaia","year":"2019","journal-title":"Front. Physiol."},{"issue":"10122","key":"10.1016\/j.pupt.2026.102409_bib5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(17)33311-1","article-title":"Asthma","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet."},{"issue":"6","key":"10.1016\/j.pupt.2026.102409_bib6","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jaci.2021.10.001","article-title":"Advances in asthma: new understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management","volume":"148","author":"Miller","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.pupt.2026.102409_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/14728214.2025.2460529","article-title":"Emerging biological treatments for asthma","volume":"30","author":"Pastore","year":"2025","journal-title":"Expet Opin. Emerg. Drugs"},{"issue":"10","key":"10.1016\/j.pupt.2026.102409_bib9","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2217\/imt-2019-0008","article-title":"Dupilumab in the treatment of asthma","volume":"11","author":"Grey","year":"2019","journal-title":"Immunotherapy"},{"key":"10.1016\/j.pupt.2026.102409_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.851940","article-title":"Interleukins 4 and 13 in asthma: key pathophysiologic cytokines and druggable molecular targets","volume":"13","author":"Pelaia","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.pupt.2026.102409_bib11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/jpm12040593","article-title":"Specific therapy for T2 asthma","volume":"12","author":"Bagnasco","year":"2022","journal-title":"J. Personalized Med."},{"issue":"26","key":"10.1016\/j.pupt.2026.102409_bib12","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"26","key":"10.1016\/j.pupt.2026.102409_bib13","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1056\/NEJMoa1804093","article-title":"Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma","volume":"378","author":"Rabe","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pupt.2026.102409_bib14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2147\/JAA.S328988","article-title":"Short-term evaluation of dupilumab effects in patients with severe asthma and nasal polyposis","volume":"14","author":"Pelaia","year":"2021","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.pupt.2026.102409_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1121237","article-title":"Real-life effects of dupilumab in patients with severe type 2 asthma, according to atopic trait and presence of chronic rhinosinusitis with nasal polyps","volume":"14","author":"Pelaia","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.pupt.2026.102409_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S2213-2600(24)00362-X","article-title":"Effect of dupilumab on exhaled nitric oxide, mucus plugs, and functional respiratory imaging in patients with type 2 asthma (VESTIGE): a randomised, double-blind, placebo-controlled, phase 4 trial","volume":"13","author":"Castro","year":"2025","journal-title":"Lancet Respir. Med."},{"issue":"2","key":"10.1016\/j.pupt.2026.102409_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","volume":"99","author":"Koenig","year":"1999","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.pupt.2026.102409_bib18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/thx.2004.026484","article-title":"Asthma and incident cardiovascular disease: the Atherosclerosis Risk in Communities Study","volume":"60","author":"Schanen","year":"2005","journal-title":"Thorax"},{"issue":"9","key":"10.1016\/j.pupt.2026.102409_bib19","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003448","article-title":"Late-Onset asthma predicts cardiovascular disease events: the Wisconsin sleep cohort","volume":"5","author":"Tattersall","year":"2016","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.pupt.2026.102409_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4104\/pcrj.2013.00107","article-title":"Chronic disease co-morbidity of asthma and unscheduled asthma care among adults: results of the national telephone health interview survey German Health Update (GEDA) 2009 and 2010","volume":"23","author":"Steppuhn","year":"2014","journal-title":"Prim. Care Respir. J."},{"issue":"14","key":"10.1016\/j.pupt.2026.102409_bib21","first-page":"5081","article-title":"Bronchial asthma and risk of 4 specific cardiovascular diseases and cardiovascular mortality: a meta-analysis of cohort studies","volume":"26","author":"Hua","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"23","key":"10.1016\/j.pupt.2026.102409_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026644","article-title":"Persistent asthma is associated with carotid plaque in MESA","volume":"11","author":"Tattersall","year":"2022","journal-title":"J. Am. Heart Assoc."},{"issue":"4","key":"10.1016\/j.pupt.2026.102409_bib23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1081-1206(10)62039-X","article-title":"The association of sensitive systemic inflammation markers with bronchial asthma","volume":"89","author":"Jousilahti","year":"2002","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.pupt.2026.102409_bib24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fphar.2020.00166","article-title":"Cytokines at the interplay between asthma and atherosclerosis?","volume":"11","author":"Gurgone","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.pupt.2026.102409_bib25","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0002-9149(96)00147-6","article-title":"Elevation of the plasma histamine concentration in the coronary circulation in patients with variant angina","volume":"77","author":"Sakata","year":"1996","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.pupt.2026.102409_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1081\/JAS-120026073","article-title":"Endothelial dysfunction in patients with asthma: the role of polymorphisms of ACE and endothelial NOS genes","volume":"41","author":"Yildiz","year":"2004","journal-title":"J. Asthma"},{"issue":"6","key":"10.1016\/j.pupt.2026.102409_bib27","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/ATVBAHA.115.305452","article-title":"Asthma predicts cardiovascular disease events: the multi-ethnic study of atherosclerosis","volume":"35","author":"Tattersall","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.pupt.2026.102409_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156002","article-title":"IL-4 causes hyperpermeability of vascular endothelial cells through Wnt5A signaling","volume":"11","author":"Skaria","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.pupt.2026.102409_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.185.3.461","article-title":"Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells","volume":"185","author":"Rinc\u00f3n","year":"1997","journal-title":"J. Exp. Med."},{"issue":"Supplement_1","key":"10.1016\/j.pupt.2026.102409_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/jeae333.415","article-title":"Standard and advanced echocardiographic analysis of patients with severe asthma","volume":"26","author":"Mandoli","year":"2025","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"3","key":"10.1016\/j.pupt.2026.102409_bib31","first-page":"231","article-title":"Echocardiographic assessment of ventricular function in young patients with asthma","volume":"110","author":"De-Paula","year":"2018","journal-title":"Arq. Bras. Cardiol."},{"issue":"3","key":"10.1016\/j.pupt.2026.102409_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0873-2159(15)30244-0","article-title":"Echocardiograph alterations in asthma patients","volume":"14","author":"Mancini","year":"2008","journal-title":"Rev. Port. Pneumol."},{"issue":"6","key":"10.1016\/j.pupt.2026.102409_bib33","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3390\/biom13060955","article-title":"Emergent inflammatory markers and echocardiographic indices in patients with bronchial asthma","volume":"13","author":"Gkavogiannakis","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.pupt.2026.102409_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejcdt.2013.04.001","article-title":"Echocardiographic evaluation of ventricular function in young adults with bronchial asthma","volume":"62","author":"Abdalla","year":"2013","journal-title":"Egypt. J. Chest Dis. Tuberc."},{"issue":"2","key":"10.1016\/j.pupt.2026.102409_bib35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.pupt.2026.102409_bib36","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00588-2019","article-title":"Management of severe asthma: a European Respiratory Society\/American Thoracic Society guideline","volume":"55","author":"Holguin","year":"2020","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.pupt.2026.102409_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"6","key":"10.1016\/j.pupt.2026.102409_bib38","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/ehjci\/jey042","article-title":"Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"19","author":"Badano","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"issue":"3","key":"10.1016\/j.pupt.2026.102409_bib39","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2006.01.011","article-title":"Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists","volume":"117","author":"Schatz","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.pupt.2026.102409_bib40","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","article-title":"Standardization of spirometry 2019 update. An official American thoracic Society and European respiratory Society technical statement","volume":"200","author":"Graham","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.pupt.2026.102409_bib41","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00965-2016","article-title":"A European Respiratory Society technical standard: exhaled biomarkers in lung disease","volume":"49","author":"Horv\u00e1th","year":"2017","journal-title":"Eur. Respir. J."},{"issue":"9","key":"10.1016\/j.pupt.2026.102409_bib42","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3390\/biomedicines9091096","article-title":"The role of dupilumab in severe asthma","volume":"9","author":"Ricciardolo","year":"2021","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.pupt.2026.102409_bib43","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/biomedicines12020390","article-title":"Dupilumab efficacy on asthma functional, inflammatory, and patient-reported outcomes across different disease phenotypes and severity: a real-life perspective","volume":"12","author":"Caminati","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.pupt.2026.102409_bib44","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/jcm13010291","article-title":"Clinical remission in patients affected by severe eosinophilic asthma on dupilumab therapy: a long-term real-life Study","volume":"13","author":"Quarato","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.pupt.2026.102409_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1232345","article-title":"Cardio-respiratory interactions in acute asthma","volume":"14","author":"Caplan","year":"2023","journal-title":"Front. Physiol."},{"issue":"11","key":"10.1016\/j.pupt.2026.102409_bib46","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3390\/jpm12111847","article-title":"Echocardiographic evaluation of the cardiac chambers in asthmatic patients: the BADA (blood pressure levels, clinical features and markers of subclinical cardiovascular damage of asthma patients) Study-ECO","volume":"12","author":"Di Raimondo","year":"2022","journal-title":"J. Personalized Med."},{"issue":"1","key":"10.1016\/j.pupt.2026.102409_bib47","doi-asserted-by":"crossref","DOI":"10.15212\/CVIA.2025.0014","article-title":"Type 2 inflammation: a potential clinical link between asthma and cardiovascular diseases","volume":"10","author":"Yang","year":"2025","journal-title":"CVIA"},{"issue":"10","key":"10.1016\/j.pupt.2026.102409_bib48","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s40265-024-02086-5","article-title":"Asthma and cardiovascular diseases: navigating mutual pharmacological interferences","volume":"84","author":"Cazzola","year":"2024","journal-title":"Drugs"},{"issue":"7","key":"10.1016\/j.pupt.2026.102409_bib49","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.arbres.2018.10.016","article-title":"Asthma: a new cardiovascular risk factor?","volume":"55","author":"Picado","year":"2019","journal-title":"Arch. Bronconeumol."},{"key":"10.1016\/j.pupt.2026.102409_bib50","article-title":"Association between asthma and all-cause mortality and cardiovascular disease morbidity and mortality: a meta-analysis of cohort studies","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"5","key":"10.1016\/j.pupt.2026.102409_bib51","doi-asserted-by":"crossref","first-page":"H833","DOI":"10.1152\/ajpheart.00310.2022","article-title":"Interleukin 4\/13 signaling in cardiac regeneration and repair","volume":"323","author":"Bakhshian Nik","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.pupt.2026.102409_bib52","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jaip.2023.03.020","article-title":"Dupilumab inhibits vascular leakage of blood proteins into atopic dermatitis skin","volume":"11","author":"Leung","year":"2023","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.pupt.2026.102409_bib53","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3389\/fimmu.2018.00888","article-title":"Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes","volume":"9","author":"Junttila","year":"2018","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.pupt.2026.102409_bib54","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1161\/HYPERTENSIONAHA.115.05627","article-title":"Profibrotic role for Interleukin-4 in cardiac remodeling and dysfunction","volume":"66","author":"Peng","year":"2015","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.pupt.2026.102409_bib55","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/labinvest.2008.61","article-title":"Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway","volume":"88","author":"Aoudjehane","year":"2008","journal-title":"Lab. Invest."},{"issue":"6","key":"10.1016\/j.pupt.2026.102409_bib56","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1084\/jem.194.6.809","article-title":"Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)","volume":"194","author":"Lee","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pupt.2026.102409_bib57","article-title":"CD206+IL-4R\u03b1+ macrophages are drivers of adverse cardiac remodeling in ischemic Cardiomyopathy","author":"Wang","year":"2025","journal-title":"Circulation"},{"issue":"2 Pt 1","key":"10.1016\/j.pupt.2026.102409_bib58","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jcmg.2017.11.017","article-title":"Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction","volume":"11","author":"Potter","year":"2018","journal-title":"JACC, Cardiovasc. Imaging"},{"issue":"18","key":"10.1016\/j.pupt.2026.102409_bib59","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.jacc.2018.02.064","article-title":"Global longitudinal strain to predict mortality in patients with acute heart failure","volume":"71","author":"Park","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.pupt.2026.102409_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2025.108203","article-title":"Clinical response and remission in patients treated with dupilumab for severe asthma: results from the nationwide Danish Severe Asthma Register","volume":"245","author":"Hansen","year":"2025","journal-title":"Respir. Med."},{"key":"10.1016\/j.pupt.2026.102409_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1187100","article-title":"The role of glucocorticoids in increasing cardiovascular risk","volume":"10","author":"Deng","year":"2023","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553926000027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553926000027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:34:43Z","timestamp":1774654483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553926000027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":60,"alternative-id":["S1094553926000027"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2026.102409","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Echocardiographic effects of dupilumab in patients with severe type 2 asthma","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2026.102409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102409"}}