{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:19:09Z","timestamp":1788293949280,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.pupt.2026.102440","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:27:36Z","timestamp":1787495256000},"page":"102440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy and safety of magnesium glycinate as add on therapy in hypomagnesemic asthma and chronic obstructive pulmonary disease patients: A randomised controlled study assessing inflammatory biomarkers"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1706-3935","authenticated-orcid":false,"given":"Maneesh Kumar","family":"Maddirevula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhasaparur G.","family":"Rajanandh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boman","family":"Wesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62784-8","article-title":"Parallel detection of multiple biomarkers in a point-of-care-competent device for the prediction of exacerbations in chronic inflammatory lung disease","volume":"14","author":"R\u00f6ckendorf","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12950-022-00308-9","article-title":"Recent evidence from omic analysis for redox signalling and mitochondrial oxidative stress in COPD","volume":"19","author":"Mumby","year":"2022","journal-title":"J. Inflamm."},{"key":"10.1016\/j.pupt.2026.102440_bib3","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.2147\/COPD.S268955","article-title":"Systemic cytokine profiles of CD4+ T lymphocytes correlate with clinical features and functional status in stable COPD","volume":"15","author":"Uzeloto","year":"2020","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.59779\/jiomnepal.1147","article-title":"Nebulized magnesium sulphate versus saline as an adjuvant in acute exacerbation of chronic obstructive pulmonary disease in a tertiary centre of Nepal: a randomized control study","volume":"43","author":"Bajracharya","year":"2021","journal-title":"Journal of Institute of Medicine Nepal"},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s40520-021-01921-z","article-title":"Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients","volume":"34","author":"Zanforlini","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41533-019-0116-z","article-title":"The role of oral magnesium supplements for the management of stable bronchial asthma: a systematic review and meta-analysis","volume":"29","author":"Abuabat","year":"2019","journal-title":"npj Primary Care Respir. Med."},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib7","article-title":"Efficacy of salmeterol and magnesium isoglycyrrhizinate combination treatment in rats with chronic obstructive pulmonary disease","volume":"12","author":"Yang","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s12890-021-01745-7","article-title":"Magnesium isoglycyrrhizinate inhibits airway inflammation in rats with chronic obstructive pulmonary disease","volume":"21","author":"Yang","year":"2021","journal-title":"BMC Pulm. Med."},{"issue":"2","key":"10.1016\/j.pupt.2026.102440_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5603\/ARM.a2022.0012","article-title":"Efficacy of magnesium sulfate in the chronic obstructive pulmonary disease population: a systematic review and meta-analysis","volume":"90","author":"Jahangir","year":"2022","journal-title":"Adv Respir Med"},{"issue":"6","key":"10.1016\/j.pupt.2026.102440_bib10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3390\/antiox14060740","article-title":"Unlocking the power of magnesium: a systematic review and meta-analysis regarding its role in oxidative stress and inflammation","volume":"14","author":"Cepeda","year":"2025","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.pupt.2026.102440_bib11","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1007\/s12011-021-02783-2","article-title":"The effect of oral magnesium supplementation on inflammatory biomarkers in adults: a comprehensive systematic review and dose\u2013response meta-analysis of randomized clinical trials","volume":"200","author":"Talebi","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"4","key":"10.1016\/j.pupt.2026.102440_bib12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.5114\/aoms.2018.75719","article-title":"Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis","volume":"14","author":"Mazidi","year":"2018","journal-title":"Arch. Med. Sci."},{"issue":"3","key":"10.1016\/j.pupt.2026.102440_bib13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/nu14030679","article-title":"Effect of magnesium supplementation on inflammatory parameters: a meta-analysis of randomized controlled trials","volume":"14","author":"Veronese","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib14","first-page":"2025","article-title":"Molecular impact of magnesium\u2010mediated immune regulation in diseases","volume":"8","author":"Sadikan","year":"2025","journal-title":"Sci. Tech. Rep."},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s41043-023-00423-0","article-title":"A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer","volume":"42","author":"Ashique","year":"2023","journal-title":"J. Health Popul. Nutr."},{"issue":"3","key":"10.1016\/j.pupt.2026.102440_bib16","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1017\/S0033291798006667","article-title":"Development of the world health organization WHOQOL-BREF quality of life assessment","volume":"28","year":"1998","journal-title":"Psychol. Med."},{"issue":"5","key":"10.1016\/j.pupt.2026.102440_bib17","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1751-7176.2008.07572.x","article-title":"Retracted: predictive validity of a medication adherence measure in an outpatient setting","volume":"10","author":"Morisky","year":"2008","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.pupt.2026.102440_bib18","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.1199","article-title":"Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis","volume":"3","author":"Wei","year":"2015","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib19","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2587931","article-title":"Chronic obstructive pulmonary disease (COPD) and autoimmune diseases: unravelling complex interactions","volume":"57","author":"Ceasovschih","year":"2025","journal-title":"Ann. Med."},{"issue":"6","key":"10.1016\/j.pupt.2026.102440_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1753-4887.2010.00293.x","article-title":"Magnesium, inflammation, and obesity in chronic disease","volume":"68","author":"Nielsen","year":"2010","journal-title":"Nutr. Rev."},{"issue":"4","key":"10.1016\/j.pupt.2026.102440_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7603\/s40681-016-0020-6","article-title":"Magnesium deficiency and oxidative stress: an update","volume":"6","author":"Zheltova","year":"2016","journal-title":"Biomedicine"},{"issue":"3","key":"10.1016\/j.pupt.2026.102440_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.pupt.2026.102440_bib23","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1001\/archinte.1995.00430050072008","article-title":"Magnesium sulfate in exacerbations of chronic obstructive pulmonary disease","volume":"155","author":"Skorodin","year":"1995","journal-title":"Arch. Intern. Med."},{"issue":"2","key":"10.1016\/j.pupt.2026.102440_bib24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1378\/chest.122.2.489","article-title":"IV magnesium sulfate in the treatment of acute severe asthma","volume":"122","author":"Silverman","year":"2002","journal-title":"Chest"},{"issue":"22","key":"10.1016\/j.pupt.2026.102440_bib25","doi-asserted-by":"crossref","DOI":"10.3310\/hta18220","article-title":"The 3Mg trial: a randomised controlled trial of intravenous or nebulised magnesium sulphate versus placebo in adults with acute severe asthma","volume":"18","author":"Goodacre","year":"2014","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.pupt.2026.102440_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2023.1211949","article-title":"Magnesium sulfate treatment for acute severe asthma in adults\u2014a systematic review and meta-analysis","volume":"4","author":"Rovsing","year":"2023","journal-title":"Frontiers in Allergy"},{"key":"10.1016\/j.pupt.2026.102440_bib27","first-page":"23","article-title":"Intravenous magnesium sulfate for asthma exacerbations in children: systematic review with meta-analysis","volume":"52","author":"Ambro\u017cej","year":"2024","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.pupt.2026.102440_bib28","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.71392","article-title":"Magnesium matters: a comprehensive review of its vital role in health and diseases","author":"Fatima","year":"2024","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.pupt.2026.102440_bib29","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/jalh.jalh_16_25","article-title":"Association of Serum magnesium level with frequency of acute exacerbations in chronic obstructive pulmonary disease patients: a prospective observational study","volume":"5","author":"Khan","year":"2025","journal-title":"Journal of Advanced Lung Health"},{"issue":"2","key":"10.1016\/j.pupt.2026.102440_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/ijmh.ijmh_62_24","article-title":"Association between Serum magnesium levels and acute exacerbations in chronic obstructive pulmonary disease patients","volume":"30","author":"Kumar","year":"2025","journal-title":"International Journal of Medicine and Health Development"},{"issue":"1","key":"10.1016\/j.pupt.2026.102440_bib31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s43168-026-00540-4","article-title":"Association between serum magnesium levels and severity of acute exacerbations in COPD: a cross-sectional study","volume":"20","author":"Siroos","year":"2026","journal-title":"The Egyptian Journal of Bronchology"},{"issue":"5","key":"10.1016\/j.pupt.2026.102440_bib32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4103\/lungindia.lungindia_55_18","article-title":"Serum magnesium levels and its correlation with level of control in patients with asthma: a hospital-based, cross-sectional, prospective study","volume":"35","author":"Daliparty","year":"2018","journal-title":"Lung India"},{"issue":"7","key":"10.1016\/j.pupt.2026.102440_bib33","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1164\/rccm.202301-0106PP","article-title":"Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary","volume":"207","author":"Agust\u00ed","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.pupt.2026.102440_bib34","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1183\/09031936.00102509","article-title":"Development and first validation of the COPD assessment test","volume":"34","author":"Jones","year":"2009","journal-title":"Eur. Respir. J."}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553926000337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553926000337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:03:40Z","timestamp":1788293020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553926000337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":34,"alternative-id":["S1094553926000337"],"URL":"https:\/\/doi.org\/10.1016\/j.pupt.2026.102440","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of magnesium glycinate as add on therapy in hypomagnesemic asthma and chronic obstructive pulmonary disease patients: A randomised controlled study assessing inflammatory biomarkers","name":"articletitle","label":"Article Title"},{"value":"Pulmonary Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pupt.2026.102440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102440"}}