{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T10:25:40Z","timestamp":1768299940876,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Papillomavirus Research"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.pvr.2020.100206","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T16:05:11Z","timestamp":1597939511000},"page":"100206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["CINtec PLUS and cobas HPV testing for triaging Canadian women referred to colposcopy with a history of low-grade squamous intraepithelial lesion: Baseline findings"],"prefix":"10.1016","volume":"10","author":[{"given":"Sam","family":"Ratnam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Alaghehbandan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Schell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Needle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Ecobichon-Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizhong Peter","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mozibur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin","family":"Costescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Elit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Zahariadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Chernesky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pvr.2020.100206_bib1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0002-9378(03)00413-7","article-title":"A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations","volume":"188","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pvr.2020.100206_bib2","series-title":"Ontario Cervical Screening Guidelines Summary","year":"2016"},{"key":"10.1016\/j.pvr.2020.100206_bib3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/dc.22944","article-title":"Performance of ProEx C and PreTect HPV-Proofer E6\/E7 mRNA tests in comparison with the Hybrid Capture 2 HPV DNA test for triaging ASCUS and LSIL cytology","volume":"41","author":"Alaghehbandan","year":"2013","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.pvr.2020.100206_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejogrb.2017.01.009","article-title":"Diagnostic performance of dual-staining cytology for cervical cancer screening: a systematic literature review","volume":"210","author":"Tjalma","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.pvr.2020.100206_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejogrb.2017.01.010","article-title":"The impact on women's health and the cervical cancer screening budget of primary HPV screening with dual-stain cytology triage in Belgium","volume":"212","author":"Tjalma","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.pvr.2020.100206_bib6","doi-asserted-by":"crossref","first-page":"S587","DOI":"10.4103\/0973-1482.183216","article-title":"Meta-analysis on the performance of p16\/Ki-67 dual immunostaining in detecting high-grade cervical intraepithelial neoplasm","volume":"14","author":"Sun","year":"2018","journal-title":"J. Canc. Res. Therapeut."},{"key":"10.1016\/j.pvr.2020.100206_bib7","first-page":"1817","article-title":"Progress in immunocytochemical staining for cervical cancer screening","volume":"11","author":"Sun","year":"2019","journal-title":"Canc. Manag. Res."},{"key":"10.1016\/j.pvr.2020.100206_bib8","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.7150\/jca.32743","article-title":"Application of p16\/Ki-67 dual-staining cytology in cervical cancers","volume":"10","author":"Yu","year":"2019","journal-title":"J. Canc."},{"key":"10.1016\/j.pvr.2020.100206_bib9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cncy.20140","article-title":"p16\/Ki-67 dual-stain cytology in the triage of ASCUS and LSIL Papanicolaou cytology: results from the European equivocal or mildly abnormal Papanicolaou cytology study","volume":"119","author":"Schmidt","year":"2011","journal-title":"Canc. Cytopathol."},{"key":"10.1016\/j.pvr.2020.100206_bib10","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/jnci\/djt235","article-title":"Screening for cervical cancer precursors with p16\/Ki-67 dual-stained cytology: results of the PALMS study","volume":"105","author":"Ikenberg","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.pvr.2020.100206_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/cncy.21542","article-title":"Prospective evaluation of p16\/Ki-67 dual-stained cytology for managing women with abnormal Papanicolaou cytology: PALMS study results","volume":"123","author":"Bergeron","year":"2015","journal-title":"Canc. Cytopathol."},{"key":"10.1016\/j.pvr.2020.100206_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/cyt.12317","article-title":"Triage of LSILS\/ASC-US with p16\/Ki-67 dual staining and human papillomavirus testing: a 2-year prospective study","volume":"27","author":"White","year":"2016","journal-title":"Cytopathology"},{"key":"10.1016\/j.pvr.2020.100206_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/cncy.22103","article-title":"Meta-analysis of the accuracy of p16 or p16\/Ki-67 immunocytochemistry versus HPV testing for the detection of CIN2+\/CIN3+ in triage of women with minor abnormal cytology","volume":"127","author":"Peeters","year":"2019","journal-title":"Canc. Cytopathol."},{"key":"10.1016\/j.pvr.2020.100206_bib14","doi-asserted-by":"crossref","first-page":"46.e1","DOI":"10.1016\/j.ajog.2011.07.024","article-title":"The ATHENA human papillomavirus study: design, methods, and baseline results","volume":"206","author":"Wright","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pvr.2020.100206_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2012.11.020","article-title":"Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing, and genotyping for HPV 16\/18: results from the ATHENA HPV study","volume":"208","author":"Cox","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pvr.2020.100206_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ygyno.2014.11.076","article-title":"Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test","volume":"136","author":"Wright","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.pvr.2020.100206_bib17","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJMoa021641","article-title":"Epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Munoz","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pvr.2020.100206_bib18","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/jnci\/dji187","article-title":"The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice","volume":"97","author":"Khan","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.pvr.2020.100206_bib19","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1470-2045(10)70230-8","article-title":"Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study","volume":"11","author":"de Sanjos\u00e9","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.pvr.2020.100206_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ygyno.2014.12.022","article-title":"Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance","volume":"136","author":"Huh","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.pvr.2020.100206_bib21","series-title":"Recommended Best Practices for Delivery of Colposcopy Services in Ontario","author":"Clinical guidance","year":"2016"},{"key":"10.1016\/j.pvr.2020.100206_bib22","series-title":"Cervical Cancer Screening in Canada: Environmental Scan","year":"2018"},{"key":"10.1016\/j.pvr.2020.100206_bib23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/ijc.27723","article-title":"Human papillomavirus testing for triage of women with low-grade squamous intraepithelial lesions","volume":"132","author":"Cuzik","year":"2013","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.pvr.2020.100206_bib24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ajog.2007.07.049","article-title":"Risk assessment to guide the prevention of cervical cancer","volume":"197","author":"Castle","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pvr.2020.100206_bib25","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/bjc.2011.351","article-title":"Use of HC2 to triage women with borderline and mild dyskaryosis in the UK","volume":"105","author":"Arbyn","year":"2011","journal-title":"BJC (Br. J. Cancer)"},{"key":"10.1016\/j.pvr.2020.100206_bib26","article-title":"Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis","volume":"360","author":"Tainio","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.pvr.2020.100206_bib27","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/ijc.27485","article-title":"Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer","volume":"131","author":"Guan","year":"2012","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.pvr.2020.100206_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.7326\/M15-2735","article-title":"Genotyping for human papillomavirus types 16 and 18 in women with minor cervical lesions: a systematic review and meta-analysis","volume":"166","author":"Arbyn","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.pvr.2020.100206_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/93.4.293","article-title":"Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial","volume":"93","author":"Solomon","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.pvr.2020.100206_bib30","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1128\/JCM.00265-12","article-title":"Cytology and human papillomavirus testing 6 to 12 months after ASCUS or LSIL cytology in organized screening to predict high-grade cervical neoplasia between screening rounds","volume":"50","author":"Trop\u00e9","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.pvr.2020.100206_bib31","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1582-4934.2008.00631.x","article-title":"Triage of women with equivocal or low-grade cervical cytology results: a meta-analysis of the HPV positivity rate","volume":"13","author":"Arbyn","year":"2009","journal-title":"J. Cell Mol. Med."}],"updated-by":[{"DOI":"10.1016\/j.tvr.2021.200215","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000}}],"container-title":["Papillomavirus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405852120300446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405852120300446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T23:07:05Z","timestamp":1608246425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405852120300446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":31,"alternative-id":["S2405852120300446"],"URL":"https:\/\/doi.org\/10.1016\/j.pvr.2020.100206","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.tvr.2021.200215","asserted-by":"object"}]},"ISSN":["2405-8521"],"issn-type":[{"value":"2405-8521","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CINtec PLUS and cobas HPV testing for triaging Canadian women referred to colposcopy with a history of low-grade squamous intraepithelial lesion: Baseline findings","name":"articletitle","label":"Article Title"},{"value":"Papillomavirus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pvr.2020.100206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100206"}}