{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:23:57Z","timestamp":1781648637142,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiology Case Reports"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.radcr.2023.08.059","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:31:14Z","timestamp":1693632674000},"page":"4036-4041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report"],"prefix":"10.1016","volume":"18","author":[{"given":"Michimi","family":"Otani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8165-0780","authenticated-orcid":false,"given":"Miki","family":"Nishimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Iwamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayasu","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Nakaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Miyatake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Yoshimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-9529","authenticated-orcid":false,"given":"Tomoaki","family":"Yamanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2375-4919","authenticated-orcid":false,"given":"Tomohiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Osaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Toi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-7967","authenticated-orcid":false,"given":"Yu","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-0196","authenticated-orcid":false,"given":"Tetsuya","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2375-5321","authenticated-orcid":false,"given":"Takuji","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radcr.2023.08.059_bib0001","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jso.2930170302","article-title":"Efforts to explain spontaneous regression of cancer","volume":"17","author":"Cole","year":"1981","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.radcr.2023.08.059_bib0002","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.lungcan.2007.05.005","article-title":"A case of spontaneous regression of small cell lung cancer with progression of paraneoplastic sensory neuropathy","volume":"58","author":"Hirano","year":"2007","journal-title":"Lung Cancer"},{"key":"10.1016\/j.radcr.2023.08.059_bib0003","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.2169\/internalmedicine.7190-21","article-title":"Spontaneous regression of small cell lung carcinoma and associated hemichorea","volume":"60","author":"Shibata","year":"2021","journal-title":"Intern Med"},{"key":"10.1016\/j.radcr.2023.08.059_bib0004","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.lungcan.2014.10.015","article-title":"Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy","volume":"87","author":"Kitai","year":"2015","journal-title":"Lung Cancer"},{"key":"10.1016\/j.radcr.2023.08.059_bib0005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1017\/S0317167100002729","article-title":"Paraneoplastic sensory neuronopathy and spontaneous regression of small cell lung cancer","volume":"30","author":"Gill","year":"2003","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.radcr.2023.08.059_bib0006","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.01.2009.1486","article-title":"Paraneoplastic sensorimotor neuropathy associated with regression of small cell lung carcinoma","author":"Mawhinney","year":"2010","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.radcr.2023.08.059_bib0007","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0140-6736(93)92485-C","article-title":"Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies","volume":"341","author":"Darnell","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.radcr.2023.08.059_bib0008","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.3389\/fimmu.2019.02965","article-title":"The intriguing history of cancer immunotherapy","volume":"10","author":"Dobosz","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.radcr.2023.08.059_bib0009","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s40792-022-01510-w","article-title":"A spontaneous reduction in tumor size of a thymic carcinoma: a case report","volume":"8","author":"Kuroki","year":"2022","journal-title":"Surg Case Rep"},{"key":"10.1016\/j.radcr.2023.08.059_bib0010","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1111\/1759-7714.14124","article-title":"Complete spontaneous remission of small cell lung cancer in the absence of specific treatment: a case report","volume":"12","author":"Song","year":"2021","journal-title":"Thorac Cancer"},{"key":"10.1016\/j.radcr.2023.08.059_bib0011","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2169\/internalmedicine.52.0284","article-title":"Small-cell lung cancer exhibiting spontaneous regression","volume":"52","author":"Iwakami","year":"2013","journal-title":"Intern Med"},{"key":"10.1016\/j.radcr.2023.08.059_bib0012","first-page":"1190","article-title":"Chance to rein in a cancer\u2013Spontaneous regression of lung carcinoma (1988-2018): a 30-year perspective","volume":"13","author":"Zhang","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.radcr.2023.08.059_bib0013","first-page":"362","article-title":"Paraneoplastic neurological syndrome: an evolving story","volume":"8","author":"Jitprapaikulsan","year":"2021","journal-title":"Neurooncol Pract"},{"key":"10.1016\/j.radcr.2023.08.059_bib0014","doi-asserted-by":"crossref","DOI":"10.1177\/1756286420985323","article-title":"Paraneoplastic neurological syndromes: clinical presentations and management","volume":"14","author":"Devine","year":"2021","journal-title":"Ther Adv Neurol Disord"},{"key":"10.1016\/j.radcr.2023.08.059_bib0015","first-page":"67","article-title":"Paraneoplastic neurologic disorders","volume":"23","author":"Gilligan","year":"2023","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.radcr.2023.08.059_bib0016","first-page":"197","article-title":"Paraneoplastic syndromes associated with lung cancer","volume":"5","year":"2014","journal-title":"World J Clin Oncol"},{"key":"10.1016\/j.radcr.2023.08.059_bib0017","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4065\/mcp.2010.0099","article-title":"Paraneoplastic syndromes: an approach to diagnosis and treatment","volume":"85","author":"Pelosof","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.radcr.2023.08.059_bib0018","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1016\/j.athoracsur.2019.08.080","article-title":"Thymic small cell carcinoma associated with Lambert-Eaton Myasthenic syndrome","volume":"109","author":"Hashimoto","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.radcr.2023.08.059_bib0019","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ncl.2018.01.008","article-title":"Lambert-Eaton Myasthenic syndrome","volume":"36","author":"Kesner","year":"2018","journal-title":"Neurol Clin"},{"key":"10.1016\/j.radcr.2023.08.059_bib0020","first-page":"e5450","article-title":"Recent advances and therapeutic options in Lambert-Eaton Myasthenic syndrome","volume":"11","author":"Anwar","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.radcr.2023.08.059_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11081035","article-title":"Presynaptic paraneoplastic disorders of the neuromuscular junction: an update","volume":"11","author":"Giannoccaro","year":"2021","journal-title":"Brain Sci"},{"key":"10.1016\/j.radcr.2023.08.059_bib0022","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1007\/s00415-017-8541-9","article-title":"Lambert-Eaton Myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer","volume":"264","author":"Schoser","year":"2017","journal-title":"J Neurol"},{"key":"10.1016\/j.radcr.2023.08.059_bib0023","first-page":"27","article-title":"Lambert-Eaton Myasthenic syndrome: early diagnosis is key","volume":"9","author":"Ivanovski","year":"2019","journal-title":"Degener Neurol Neuromuscul Dis"},{"key":"10.1016\/j.radcr.2023.08.059_bib0024","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jneuroim.2005.04.001","article-title":"P\/Q-type calcium channel antibodies, Lambert-Eaton Myasthenic syndrome and survival in small cell lung cancer","volume":"164","author":"Wirtz","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.radcr.2023.08.059_bib0025","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1212\/WNL.0000000000003794","article-title":"Long-term survival in paraneoplastic Lambert-Eaton Myasthenic syndrome","volume":"88","author":"Maddison","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.radcr.2023.08.059_bib0026","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1200\/JCO.2008.20.6169","article-title":"SOX antibodies in small-cell lung cancer and Lambert-Eaton Myasthenic syndrome: frequency and relation with survival","volume":"27","author":"Titulaer","year":"2009","journal-title":"J Clin Oncol"}],"container-title":["Radiology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1930043323005782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1930043323005782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:02:50Z","timestamp":1761825770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1930043323005782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1930043323005782"],"URL":"https:\/\/doi.org\/10.1016\/j.radcr.2023.08.059","relation":{},"ISSN":["1930-0433"],"issn-type":[{"value":"1930-0433","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spontaneous regression of small cell lung cancer associated with Lambert-Eaton Myasthenic Syndrome: Case report","name":"articletitle","label":"Article Title"},{"value":"Radiology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radcr.2023.08.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington.","name":"copyright","label":"Copyright"}]}}