{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:36:00Z","timestamp":1793367360737,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiology Case Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.radcr.2026.06.055","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:15:41Z","timestamp":1783430141000},"page":"4414-4418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expanding the spectrum of the giant panda sign: a bright-eye variant in Wilson disease"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7713-9664","authenticated-orcid":false,"given":"Srinidhi","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3643-6758","authenticated-orcid":false,"given":"Arun","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3115-3716","authenticated-orcid":false,"given":"Jampana","family":"Sahitya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8406-1912","authenticated-orcid":false,"given":"Swathi","family":"Mulupuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7601-8047","authenticated-orcid":false,"given":"Eswar K.","family":"Sakinala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radcr.2026.06.055_bib0001","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-018-0018-3","article-title":"Wilson disease","volume":"4","author":"Cz\u0142onkowska","year":"2018","journal-title":"Nat Rev Dis rPrimers"},{"key":"10.1016\/j.radcr.2026.06.055_bib0002","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1600-0676.2003.00824.x","article-title":"Diagnosis and phenotypic classification of Wilson disease","volume":"23","author":"Ferenci","year":"2003","journal-title":"Liver Int"},{"key":"10.1016\/j.radcr.2026.06.055_bib0003","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ncl.2020.01.005","article-title":"Wilson disease: an overview and approach to management","volume":"38","author":"Mulligan","year":"2020","journal-title":"Neurol Clin."},{"issue":"6","key":"10.1016\/j.radcr.2026.06.055_bib0004","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.semdp.2019.07.008","article-title":"Wilson disease","volume":"36","author":"Guindi","year":"2019","journal-title":"Semin Diagn Pathol."},{"issue":"6","key":"10.1016\/j.radcr.2026.06.055_bib0005","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mds.22689","article-title":"Do MRI features distinguish Wilson's disease from other early onset extrapyramidal disorders? An analysis of 100 cases","volume":"25","author":"Prashanth","year":"2010","journal-title":"Mov Disord."},{"key":"10.1016\/j.radcr.2026.06.055_bib0006","series-title":"GeneReviews\u00ae","article-title":"Wilson disease","author":"Roberts","year":"2023"},{"key":"10.1016\/j.radcr.2026.06.055_bib0007","unstructured":"Medscape. Wilson Disease \u2013 Practice Essentials, Background, Etiology. eMedicine. https:\/\/emedicine.medscape.com\/article\/183456-overview#a1. Updated June 25, 2026."},{"issue":"8","key":"10.1016\/j.radcr.2026.06.055_bib0008","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1590\/0004-282x20200036","article-title":"Panda with ``bright eyes'': a rare sign in Wilson disease","volume":"78","author":"Castro","year":"2020","journal-title":"Arq Neuropsiquiatr"},{"issue":"1","key":"10.1016\/j.radcr.2026.06.055_bib0009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/0028-3886.108052","article-title":"Panda with ``bright eyes'' in Wilson's disease","volume":"61","author":"Kallollimath","year":"2013","journal-title":"Neurol India."},{"issue":"7","key":"10.1016\/j.radcr.2026.06.055_bib0010","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3390\/brainsci14070727","article-title":"11.Brain magnetic resonance imaging in Wilson's disease: significance and practical aspects. A narrative review","volume":"14","author":"Litwin","year":"2024","journal-title":"Brain Sci."},{"key":"10.1016\/j.radcr.2026.06.055_bib0011","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.clineuro.2015.07.013","article-title":"A study of MRI changes in Wilson disease and its correlation with clinical features and outcome","volume":"138","author":"Ranjan","year":"2015","journal-title":"Clin Neurol Neurosurg."},{"issue":"9","key":"10.1016\/j.radcr.2026.06.055_bib0012","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.braindev.2008.01.011","article-title":"MR spectroscopy of the brain in Leigh syndrome","volume":"30","author":"Sijens","year":"2008","journal-title":"Brain Dev."},{"issue":"3","key":"10.1016\/j.radcr.2026.06.055_bib0013","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/jnnp-2012-304426","article-title":"A guide to diagnosis and treatment of Leigh syndrome","volume":"85","author":"Baertling","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"10.1016\/j.radcr.2026.06.055_bib0014","first-page":"3966","article-title":"Hyperammonemia in inherited metabolic diseases","volume":"13","author":"H\u00e4berle","year":"2021","journal-title":"Nutrients."},{"issue":"958","key":"10.1016\/j.radcr.2026.06.055_bib0015","doi-asserted-by":"crossref","first-page":"e243","DOI":"10.1259\/bjr\/40137535","article-title":"MRI findings in methanol intoxication: A report of two cases","volume":"80","author":"Arora","year":"2007","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.radcr.2026.06.055_bib0016","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-201026","article-title":"Acute bilateral putaminal haemorrhagic necrosis in methanol poisoning","volume":"2013","author":"Thirunavukkarasu","year":"2013","journal-title":"BMJ Case Rep."},{"issue":"Suppl 2","key":"10.1016\/j.radcr.2026.06.055_bib0017","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.21037\/atm.2019.02.07","article-title":"Classification and differential diagnosis of Wilson's disease","volume":"7","author":"Hermann","year":"2019","journal-title":"Ann Transl Med."},{"issue":"15","key":"10.1016\/j.radcr.2026.06.055_bib0018","first-page":"4405","article-title":"Neurological worsening in patients with Wilson disease","volume":"11","author":"Ogrodnik","year":"2022","journal-title":"J Clin Med."},{"issue":"5","key":"10.1016\/j.radcr.2026.06.055_bib0019","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1468-1331.2003.00661.x","article-title":"MR imaging of the brain in patients with hepatic form of Wilson\u2019s disease","volume":"10","author":"Kozi\u0107","year":"2003","journal-title":"Eur J Neurol"}],"container-title":["Radiology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1930043326005005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1930043326005005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:49:20Z","timestamp":1793364560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1930043326005005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1930043326005005"],"URL":"https:\/\/doi.org\/10.1016\/j.radcr.2026.06.055","relation":{},"ISSN":["1930-0433"],"issn-type":[{"value":"1930-0433","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expanding the spectrum of the giant panda sign: a bright-eye variant in Wilson disease","name":"articletitle","label":"Article Title"},{"value":"Radiology Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radcr.2026.06.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of University of Washington.","name":"copyright","label":"Copyright"}]}}