{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:23:28Z","timestamp":1776842608179,"version":"3.51.2"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.radonc.2004.11.008","type":"journal-article","created":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T22:57:31Z","timestamp":1102978651000},"page":"117-129","source":"Crossref","is-referenced-by-count":75,"title":["Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS"],"prefix":"10.1016","volume":"74","author":[{"given":"Mahmoud","family":"Toulany","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Dittmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Peter","family":"Rodemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2004.11.008_bib1","first-page":"7350","article-title":"Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma","volume":"62","author":"Ang","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1634\/theoncologist.7-suppl_4-31","article-title":"Epidermal growth factor receptor dependence in human tumors: more than just expression?","volume":"7","author":"Arteaga","year":"2002","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2004.11.008_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0167-4889(96)00068-7","article-title":"The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation","volume":"1314","author":"Balaban","year":"1996","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/j.radonc.2004.11.008_bib4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0360-3016(01)01609-1","article-title":"EGFR overexpression and radiation response in glioblastoma multiforme","volume":"51","author":"Barker","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2004.11.008_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0955300031000112839","article-title":"Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse","volume":"79","author":"Baumann","year":"2003","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.radonc.2004.11.008_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0167-8140(94)90100-7","article-title":"Impact of overall treatment time of fractionated irradiation on local control of human FaDu squamous cell carcinoma in nude mice","volume":"32","author":"Baumann","year":"1994","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2004.11.008_bib7","first-page":"3243","article-title":"MEK1 and Erk1\/2 kinases as targets for the modulation of radiation responses","volume":"20","author":"Belka","year":"2000","journal-title":"Anticancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib8","first-page":"6597","article-title":"Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines","volume":"60","author":"Bernhard","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib9","first-page":"4343","article-title":"Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide","volume":"6","author":"Bianco","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/sj.onc.1205028","article-title":"Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family","volume":"21","author":"Bishop","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.radonc.2004.11.008_bib11","first-page":"47S","article-title":"Enhanced apoptosis with combination C225\/radiation treatment serves as the impetus for clinical investigation in head and neck cancers","volume":"18","author":"Bonner","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2004.11.008_bib12","first-page":"3986","article-title":"Akt\/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation","volume":"61","author":"Brognard","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib13","first-page":"4307","article-title":"The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner","volume":"62","author":"Chakravarti","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/oxfordjournals.annonc.a057897","article-title":"Expression of transforming growth factor alpha (TGF alpha) in breast cancer","volume":"2","author":"Ciardiello","year":"1991","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2004.11.008_bib15","first-page":"407","volume":"1","author":"Ciardiello","year":"1990","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.radonc.2004.11.008_bib16","first-page":"2958","article-title":"A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor","volume":"7","author":"Ciardiello","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib17","first-page":"405","article-title":"The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells","volume":"5","author":"Contessa","year":"1999","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1471-4914(02)02306-7","article-title":"The ErbB receptor family: a therapeutic target for cancer","volume":"8","author":"de Bono","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.radonc.2004.11.008_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1667\/0033-7587(2003)159[0283:SARIAO]2.0.CO;2","article-title":"Stress and radiation-induced activation of multiple intracellular signaling pathways","volume":"159","author":"Dent","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1080\/09553000310001610277","article-title":"Bowman\u2013Birk protease inhibitor activates DNA-dependent protein kinase and reduces formation of radiation-induced dicentric chromosomes","volume":"79","author":"Dittmann","year":"2003","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.radonc.2004.11.008_bib21","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0959-8049(02)00020-5","article-title":"Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration","volume":"38","author":"Dittrich","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.radonc.2004.11.008_bib22","first-page":"4502","article-title":"Cripto-1 induces phosphatidylinositol 3\u2032-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells","volume":"59","author":"Ebert","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/bbrc.2001.4302","article-title":"BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells","volume":"281","author":"Egeblad","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.radonc.2004.11.008_bib24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.bjc.6601037","article-title":"AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2","volume":"89","author":"Fahy","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2004.11.008_bib25","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1093\/emboj\/16.21.6439","article-title":"Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase","volume":"16","author":"Foschi","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.radonc.2004.11.008_bib26","first-page":"267","article-title":"The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines","volume":"15","author":"Gilhooly","year":"1999","journal-title":"Int J Oncol"},{"key":"10.1016\/j.radonc.2004.11.008_bib27","first-page":"7807","article-title":"Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance","volume":"63","author":"Grana","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib28","first-page":"4142","article-title":"Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase\/extracellular signal-regulated kinase kinase-independent signaling pathways","volume":"62","author":"Grana","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1667\/0033-7587(2000)154[0064:RMRRIN]2.0.CO;2","article-title":"RAS-Mediated radiation resistance is not linked to MAP kinase activation in two bladder carcinoma cell lines","volume":"154","author":"Gupta","year":"2000","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib30","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0360-3016(03)00214-1","article-title":"Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002","volume":"56","author":"Gupta","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2004.11.008_bib31","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1128\/MCB.21.17.5846-5856.2001","article-title":"Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells","volume":"21","author":"Gupta","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.radonc.2004.11.008_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2307\/3579812","article-title":"Radiation-induced signal transduction and stress response","volume":"150","author":"Haimovitz-Friedman","year":"1998","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/srao.2002.34865","article-title":"Epidermal growth factor receptor modulation of radiation response: preclinical and clinical development","volume":"12","author":"Harari","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2004.11.008_bib34","first-page":"1935","article-title":"Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck","volume":"59","author":"Huang","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib35","first-page":"2166","article-title":"Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis","volume":"6","author":"Huang","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib36","first-page":"4300","article-title":"Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)","volume":"62","author":"Huang","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib37","first-page":"507","article-title":"Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade","volume":"1","author":"Huang","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.radonc.2004.11.008_bib38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1677\/erc.0.0080151","article-title":"The ErbB receptor tyrosine family as signal integrators","volume":"8","author":"Hynes","year":"2001","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.radonc.2004.11.008_bib39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0065-230X(08)60959-8","article-title":"Oncogenic basis of radiation resistance","volume":"61","author":"Kasid","year":"1993","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib40","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/382813a0","article-title":"Activation of Raf by ionizing radiation","volume":"382","author":"Kasid","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.radonc.2004.11.008_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1196\/annals.1318.010","article-title":"Mutant DNA in plasma of lung cancer patients: potential for monitoring response to therapy","volume":"1022","author":"Kimura","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.radonc.2004.11.008_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.radonc.2004.05.003","article-title":"Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma","volume":"72","author":"Krause","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2004.11.008_bib43","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/jnci\/93.12.921","article-title":"Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization","volume":"93","author":"Lammering","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2004.11.008_bib44","first-page":"682","article-title":"Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor","volume":"7","author":"Lammering","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0014-5793(99)00032-0","article-title":"Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor","volume":"444","author":"Lan","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.radonc.2004.11.008_bib46","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/sj.onc.1203452","article-title":"Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway","volume":"19","author":"Leu","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.radonc.2004.11.008_bib47","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0360-3016(03)00511-X","article-title":"The epidermal growth factor receptor mediates radioresistance","volume":"57","author":"Liang","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2004.11.008_bib48","first-page":"353","article-title":"Targeting the phosphatidylinositol 3-kinase\/Akt pathway for enhancing breast cancer cells to radiotherapy","volume":"2","author":"Liang","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.radonc.2004.11.008_bib49","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1098\/rspb.1985.0084","article-title":"The involvement of activated ras genes in determining the transformed phenotype","volume":"226","author":"Marshall","year":"1985","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"10.1016\/j.radonc.2004.11.008_bib50","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0360-3016(90)90407-B","article-title":"The role of the H-ras oncogene in radiation resistance and metastasis","volume":"18","author":"McKenna","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2004.11.008_bib51","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1200\/JCO.2003.01.504","article-title":"Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer","volume":"21","author":"Mendelsohn","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2004.11.008_bib52","first-page":"701","article-title":"In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody","volume":"6","author":"Milas","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib53","first-page":"7184","article-title":"The tyrosine kinase inhibitor ZD1839 (\u2018Iressa\u2019) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells","volume":"61","author":"Moasser","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib54","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/ijc.2910520325","article-title":"TGF-alpha production correlates with tumorigenicity in clones of the SW613-S human colon carcinoma cell line","volume":"52","author":"Modjtahedi","year":"1992","journal-title":"Int J Cancer"},{"key":"10.1016\/j.radonc.2004.11.008_bib55","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0360-3016(01)01671-6","article-title":"C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability","volume":"51","author":"Nasu","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2004.11.008_bib56","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0378-5173(99)00389-0","article-title":"In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS","volume":"194","author":"Nuijen","year":"2000","journal-title":"Int J Pharm"},{"key":"10.1016\/j.radonc.2004.11.008_bib57","doi-asserted-by":"crossref","first-page":"17209","DOI":"10.1074\/jbc.274.24.17209","article-title":"ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases","volume":"274","author":"Olayioye","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.radonc.2004.11.008_bib58","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1097-4652(199908)180:2<263::AID-JCP14>3.0.CO;2-H","article-title":"Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts","volume":"180","author":"Payne","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.radonc.2004.11.008_bib59","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0360-3016(01)01686-8","article-title":"Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation","volume":"51","author":"Petersen","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2004.11.008_bib60","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1124\/mol.56.3.515","article-title":"Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A","volume":"56","author":"Rajesh","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.radonc.2004.11.008_bib61","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00690598","article-title":"Oncogenes as inducers of tumor angiogenesis","volume":"14","author":"Rak","year":"1995","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.radonc.2004.11.008_bib62","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1038\/sj.onc.1202849","article-title":"Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells","volume":"18","author":"Reardon","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.radonc.2004.11.008_bib63","first-page":"7196","article-title":"The characterization of novel, dual ErbB-2\/EGFR, tyrosine kinase inhibitors potential therapy for cancer","volume":"61","author":"Rusnak","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib64","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/sj.onc.1201275","article-title":"Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation","volume":"15","author":"Schmidt-Ullrich","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.radonc.2004.11.008_bib65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2307\/3579199","article-title":"Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells","volume":"145","author":"Schmidt-Ullrich","year":"1996","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib66","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1749-6632.2002.tb04668.x","article-title":"Enhancement of radioresponse of murine tumors by ERK inhibitor","volume":"973","author":"Seong","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.radonc.2004.11.008_bib67","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1126\/science.3277276","article-title":"The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation","volume":"239","author":"Sklar","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.radonc.2004.11.008_bib68","first-page":"8203","article-title":"The phosphatidylinositide 3\u2032-kinase\/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C","volume":"61","author":"Tenzer","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib69","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3109\/10799899909038430","article-title":"Ionizing radiation stimulates existing signal transduction pathways involving the activation of epidermal growth factor receptor and ERBB-3, and changes of intracellular calcium in A431 human squamous carcinoma cells","volume":"19","author":"Todd","year":"1999","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.radonc.2004.11.008_bib70","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0360-3016(94)90523-1","article-title":"Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro","volume":"30","author":"Wollman","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2004.11.008_bib71","doi-asserted-by":"crossref","first-page":"24252","DOI":"10.1074\/jbc.M200437200","article-title":"Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation","volume":"277","author":"Wu","year":"2002","journal-title":"J Biol Chem"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814004005468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814004005468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T17:55:38Z","timestamp":1548957338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814004005468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0167814004005468"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2004.11.008","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}