{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:09:36Z","timestamp":1772813376567,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.radonc.2005.10.005","type":"journal-article","created":{"date-parts":[[2005,11,5]],"date-time":"2005-11-05T12:38:11Z","timestamp":1131194291000},"page":"117-125","source":"Crossref","is-referenced-by-count":45,"title":["Delayed rectal and urinary symptomatology in patients treated for prostate cancer by radiotherapy with or without short term neo-adjuvant androgen deprivation"],"prefix":"10.1016","volume":"77","author":[{"given":"David","family":"Christie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Denham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Steigler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedy","family":"Mameghan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"North","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel A.","family":"Spry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keen-Hun","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Wynne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Duchesne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Kovacev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Francis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Kramar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cate","family":"D'Este","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Bill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2005.10.005_bib1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ijrobp.2004.12.087","article-title":"Gastrointestinal symptoms after pelvic radiotherapy: role for the gastroenterologist?","volume":"62","author":"Andreyev","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2005.10.005_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J Res Stats Soc"},{"key":"10.1016\/j.radonc.2005.10.005_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/sj.bjc.6602301","article-title":"Pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects","volume":"92","author":"Dearnaley","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2005.10.005_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0140-6736(98)05180-0","article-title":"Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial","volume":"353","author":"Dearnaley","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2005.10.005_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0167-8140(02)00060-9","article-title":"The radiotherapeutic injury\u2014a complex \u2018wound\u2019","volume":"63","author":"Denham","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2005.10.005_bib6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0360-3016(01)01556-5","article-title":"Is it time for a new formalism to categorize normal tissue radiation injury? (Editorial)","volume":"50","author":"Denham","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2005.10.005_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0167-8140(99)00027-4","article-title":"Is there more than one late radiation proctitis syndrome?","volume":"51","author":"Denham","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2005.10.005_bib8","series-title":"Applied survival analysis: regression modeling of time to event data","article-title":"Other models and topics","author":"Hosmer","year":"1999"},{"key":"10.1016\/j.radonc.2005.10.005_bib9","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/S0360-3016(02)03742-2","article-title":"Late rectal toxicity: dose-volume effects of conformal radiotherapy for prostate cancer","volume":"54","author":"Huang","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2005.10.005_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2004.07.020","article-title":"Gastro-intestinal and genito-urinary morbidity after 3D conformal radiotherapy of prostate cancer: observations of a randomised trial","volume":"73","author":"Koper","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2005.10.005_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0167-8140(03)00193-2","article-title":"Acceptability of short term neo-adjuvant deprivation in patients with locally advanced prostate cancer","volume":"68","author":"Lamb","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2005.10.005_bib12","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/sim.4780142409","article-title":"Non-parametric methods for analysing recurrent complications of varying severity","volume":"14","author":"Lancar","year":"1995","journal-title":"Stat Med"},{"key":"10.1016\/j.radonc.2005.10.005_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalised linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"key":"10.1016\/j.radonc.2005.10.005_bib14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/jama.1995.03520260051032","article-title":"Quality-of-life outcomes in men treated for localized prostate cancer","volume":"273","author":"Litwin","year":"1995","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.radonc.2005.10.005_bib15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0360-3016(90)90095-2","article-title":"Bowel complications after radiotherapy for carcinoma of the prostate: the volume effect","volume":"18","author":"Mameghan","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2005.10.005_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0167-8140(97)00146-1","article-title":"Phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis: Trans-Tasman Radiation Oncology Group (TROG)","volume":"45","author":"O'Brien","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2005.10.005_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0360-3016(03)01445-7","article-title":"Spontaneous improvement in late rectal mucosal changes following radiotherapy for prostate cancer","volume":"58","author":"O'Brien","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2005.10.005_bib18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/0360-3016(95)00041-V","article-title":"Complicating issues in complication reporting","volume":"31","author":"Peters","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2005.10.005_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0360-3016(96)00468-3","article-title":"Late GI and GU complications in the treatment of prostate cancer","volume":"37","author":"Schultheiss","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2005.10.005_bib20","series-title":"Handbook of parametric and non-parametric statistical procedures","first-page":"907","article-title":"Goodman and Kruskal's gamma","author":"Sheskin","year":"2000"},{"key":"10.1016\/j.radonc.2005.10.005_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1440-1673.2000.00774.x","article-title":"A quality assurance audit: phase III trial of maximal androgen deprivation in prostate cancer (TROG 96.01)","volume":"44","author":"Steigler","year":"2000","journal-title":"Aust Radiol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814005004469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814005004469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T10:11:44Z","timestamp":1736071904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814005004469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0167814005004469"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2005.10.005","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}