{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:26:26Z","timestamp":1791091586056,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.radonc.2007.04.002","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T10:23:16Z","timestamp":1178533396000},"page":"156-170","source":"Crossref","is-referenced-by-count":141,"title":["Evidence-based radiation oncology in head and neck squamous cell carcinoma"],"prefix":"10.1016","volume":"85","author":[{"given":"Renzo","family":"Corv\u00f2","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2007.04.002_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1200\/JCO.2003.01.008","article-title":"An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer","volume":"21","author":"Adelstein","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib2","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1200\/JCO.2005.01.5867","article-title":"Multiagent concurrent chemoradiotherapy for locoregionally advanced Squamous Cell Head and Neck Cancer: mature results from a single institution","volume":"24","author":"Adelstein","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib3","doi-asserted-by":"crossref","unstructured":"Green FL, Page DL, Fleming ID et al., editors. AJCC cancer staging manual. 6th ed. New York: Springer; 2002.","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"10.1016\/j.radonc.2007.04.002_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/107327480200900504","article-title":"Treatment of locally advanced head and neck cancer: historical and critical review","volume":"9","author":"Al-Sarraf","year":"2002","journal-title":"Cancer Control"},{"key":"10.1016\/j.radonc.2007.04.002_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0360-3016(01)01690-X","article-title":"Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer","volume":"51","author":"Ang","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib6","first-page":"7350","article-title":"Impact of epidermal growth factor receptor overexpression on survival and pattern of relapse in patients with advanced head and neck carcinoma","volume":"62","author":"Ang","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2007.04.002_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/030089160509100107","article-title":"Altered fractionation radiotherapy in head and neck cancer: clinical issues and pitfalls of \u201cevidence-based medicine\u201d","volume":"91","author":"Antognoni","year":"2005","journal-title":"Tumori"},{"key":"10.1016\/j.radonc.2007.04.002_bib8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0360-3016(96)00430-0","article-title":"Combined post-operative radiotherapy and weekly cisplatin infusion for locally advanced head and neck cancer carcinoma. Final report of a randomized trial","volume":"36","author":"Bachaud","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.radonc.2004.07.007","article-title":"Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results","volume":"72","author":"Baumann","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib10","first-page":"124","article-title":"Assessment of tumor radiosensitivity using functional and metabolic nuclear imaging in research and clinical practice","volume":"10","author":"Belkacemy","year":"2006","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.radonc.2007.04.002_bib11","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ijrobp.2005.09.041","article-title":"French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin\/5fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma. Results at 2 years (FNCLCC-GORTEC)","volume":"64","author":"Bensadoun","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib12","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1200\/JCO.2005.06.411","article-title":"Epidermal Growth Factor Receptor Expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial","volume":"23","author":"Bentzen","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-8140(01)00358-9","article-title":"Radiotherapy-related early morbidity in head and neck cancer: quantitative clinical radiobiology as deduced from the CHART trial","volume":"60","author":"Bentzen","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib14","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced Head and Neck Cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2007.04.002_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1586\/14737140.4.3.335","article-title":"Chemoradiation in locally advanced head and neck cancer: new evidence, new challenges","volume":"4","author":"Bernier","year":"2004","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.radonc.2007.04.002_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1634\/theoncologist.10-3-215","article-title":"Chemoradiation after surgery for high-risk head and neck cancer patients: how strong is the evidence?","volume":"10","author":"Bernier","year":"2005","journal-title":"The Oncologist"},{"key":"10.1016\/j.radonc.2007.04.002_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/ncponc0201","article-title":"Alteration of radiotherapy fractionation and concurrent chemotherapy: a new frontier in head and neck oncology?","volume":"2","author":"Bernier","year":"2005","journal-title":"Nat Clin Pract Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/01.cco.0000219252.45467.88","article-title":"Radiotherapy for head and neck cancer: latest developments and future perspectives","volume":"18","author":"Bernier","year":"2006","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck","volume":"354","author":"Bonner","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2007.04.002_bib20","first-page":"22","article-title":"Update of MACH.NC (Meta-analysis of chemotherapy in Head & Neck Cancer) database focused on concomitant chemoradiotherapy","author":"Bourhis","year":"2004","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1053\/j.seminoncol.2004.09.002","article-title":"Concomitant radiochemotherapy or accelerated radiotherapy: analysis of two randomized trials of the French Head and Neck Cancer Group (GORTEC)","volume":"31","author":"Bourhis","year":"2004","journal-title":"Sem Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib22","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1200\/JCO.2006.08.057","article-title":"Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial","volume":"24","author":"Bourhis","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(06)69121-6","article-title":"Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis","volume":"368","author":"Bourhis","year":"2006","journal-title":"The Lancet"},{"key":"10.1016\/j.radonc.2007.04.002_bib24","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1056\/NEJM199806183382503","article-title":"Hyperfractionated irradiation with or without concurrent chemotherapy for locally-advanced head and neck cancer","volume":"338","author":"Brizel","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2007.04.002_bib25","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1200\/JCO.2005.05.2829","article-title":"Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous cell carcinoma of the Head and Neck: consensus, controversy and conundrum","volume":"24","author":"Brizel","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM199301213280302","article-title":"Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer","volume":"328","author":"Browman","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2007.04.002_bib27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/hed.1081","article-title":"Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer: a systematic review of the published literature with subgroup analysis","volume":"23","author":"Browman","year":"2001","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2007.04.002_bib28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1200\/JCO.2005.07.010","volume":"23","author":"Budach","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2407-6-28","article-title":"A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck","volume":"6","author":"Budach","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2007.04.002_bib30","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1093\/jnci\/91.24.2081","article-title":"Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced stage oropharynx carcinoma","volume":"91","author":"Calais","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2007.04.002_bib31","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1586\/14737140.6.7.1111","article-title":"Head and Neck cancer: past, present and future","volume":"6","author":"Chin","year":"2006","journal-title":"Exp Rev Anticancer Ther"},{"key":"10.1016\/j.radonc.2007.04.002_bib32","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<588::AID-HED2>3.0.CO;2-F","article-title":"Precisally defining high risk operable head and neck tumors based on RTOG 85-03 and 88-24: a target for postoperative radiochemotherapy?","volume":"20","author":"Cooper","year":"1998","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2007.04.002_bib33","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high risk squamous cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2007.04.002_bib34","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1002\/1097-0142(20011201)92:11<2856::AID-CNCR10132>3.0.CO;2-6","article-title":"Alternating chemoradiotherapy versus partly accelerated radiotherapy in locally advanced squamous cell carcinoma of the head and neck","volume":"92","author":"Corv\u00f2","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2007.04.002_bib35","first-page":"S8","article-title":"Five-year results of 4 week-twice daily radiation schedule-the Toronto trial","volume":"56","author":"Cummings","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-8140(97)00094-7","article-title":"A randomized multicentre trial of CHART versus conventional radiotherapy in head and neck cancer","volume":"44","author":"Dische","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib37","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1200\/JCO.1996.14.3.838","article-title":"Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region: a meta-analysis of prospective and randomized trials","volume":"14","author":"El-Sayed","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose volume and function relationships in parotid glands following conformal and intensity modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.radonc.2004.12.018","article-title":"The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study","volume":"74","author":"Eriksen","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0360-3016(97)00327-1","article-title":"Results of a European trial of etanidazole combined with radiotherapy in head and neck carcinomas","volume":"39","author":"Eschwege","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib41","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0360-3016(87)90188-X","article-title":"Failure of misonidazole-sensitized radiotherapy to impact upon Stage III\u2013IV squamous cancers of the head and neck","volume":"13","author":"Fazekas","year":"1987","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib42","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent chemotherapy and radiotherapy for preservation in advanced laryngeal cancer","volume":"349","author":"Forastiere","year":"2003","journal-title":"N Eng J Med"},{"key":"10.1016\/j.radonc.2007.04.002_bib43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0360-3016(92)90768-D","article-title":"Loss of local control with prolongation in radiotherapy","volume":"23","author":"Fowler","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3322\/canjclin.49.3.145","article-title":"Clinical highlights from the National Cancer Data base, 1999","volume":"49","author":"Frengen","year":"1999","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2007.04.002_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0360-3016(00)00663-5","article-title":"A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003","volume":"48","author":"Fu","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/sonc.2002.31531","article-title":"Tirapazamine: the prototype for a novel class of therapeutic agent targeting tumor hypoxia","volume":"29","author":"Gandara","year":"2002","journal-title":"Semin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.radonc.2003.09.011","article-title":"CT-based delineation of lymph node levels and related CTVs in the node negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines","volume":"69","author":"Gregoire","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib48","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.canrad.2004.12.004","article-title":"Intensity Modulated Radiation Therapy in head and neck squamous cell carcinoma: state of art and future challenges","volume":"9","author":"Gregoire","year":"2005","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.radonc.2007.04.002_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2006.03.009","article-title":"Proposal for the delineation of the nodal CTV in the node-positive and post-operative neck","volume":"79","author":"Gregoire","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib50","doi-asserted-by":"crossref","first-page":"vi13","DOI":"10.1093\/annonc\/mdi453","article-title":"Promising new advances in head and neck radiotherapy","volume":"16","author":"Harari","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib51","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.radonc.2006.05.016","article-title":"Hyperfractionated, accelerated chemoradiation with concurrent mitomycin-C and cisplatin in locally advanced head and neck cancer, a phase I\/II study","volume":"80","author":"Hehr","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib52","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1200\/JCO.2004.00.1990","article-title":"Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer","volume":"34","author":"Hitt","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib53","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1200\/JCO.2000.18.7.1458","article-title":"Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: a prospective randomized trial","volume":"18","author":"Jeremic","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib54","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.radonc.2004.12.004","article-title":"Concomitant boost radiotherapy with concurrent weekly cisplatin in advanced head and neck cancers: a phase I\u2013II trial","volume":"75","author":"Kumar","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.radonc.2005.01.004","article-title":"Molecular predictor and promising target: will EGFR now become a star in radiotherapy?","volume":"74","author":"Lammering","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib56","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.canrad.2005.03.005","article-title":"Propositions for the selection and the delineation of peritumoral microscopic disease volumes in oral cavity and oropharyngeal cancers (lymph nodes excluded)","volume":"9","author":"Lapeyre","year":"2005","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.radonc.2007.04.002_bib57","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1586\/14737140.6.3.405","article-title":"Radiotherapeutic management of locally advanced head and neck cancer","volume":"6","author":"Laskar","year":"2006","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.radonc.2007.04.002_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/srao.2003.50002","article-title":"The mechanism of action of radiosensitization of conventional chemotherapeutic agents","volume":"13","author":"Lawrence","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib59","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0360-3016(95)00150-W","article-title":"Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinoma","volume":"32","author":"Lee","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib60","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/jnci\/88.13.890","article-title":"Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer Phase III trial. EORTC Head and Neck Cancer Co-operative Group","volume":"88","author":"Lefebvre","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2007.04.002_bib61","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/annonc\/mdh001","article-title":"Is there still a role for neo-adjuvant chemotherapy in head and neck cancer?","volume":"15","author":"Licitra","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib62","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.cco.0000219254.53091.35","article-title":"A multidisciplinary approach to squamous cell carcinomas of the head and neck: what is new?","volume":"18","author":"Licitra","year":"2006","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib63","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.radonc.2006.03.010","article-title":"A phase II study of concomitant boost radiation plus concurrent weekly cisplatin for locally advanced unresectable head and neck carcinomas","volume":"79","author":"Medina","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib64","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1200\/JCO.2005.04.7225","article-title":"Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls","volume":"24","author":"Mendenhall","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib65","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jnci\/88.9.583","article-title":"Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous-cell carcinoma of the head and neck","volume":"88","author":"Merlano","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2007.04.002_bib66","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/bjc.1995.17","article-title":"An overview of randomized controlled trials of adjuvant chemotherapy in head and neck cancer","volume":"71","author":"Munro","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2007.04.002_bib67","unstructured":"National Comprehensive Cancer Network. Practice Guidelines: head and Neck cancer, version 1.2006. htpp\/www.nccn.org\/physician-gls\/PDF\/head-and-neck-pdf."},{"key":"10.1016\/j.radonc.2007.04.002_bib68","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2005.06.038","article-title":"Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy: an international multi-center study","volume":"77","author":"Nordsmark","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib69","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0360-3016(89)90917-6","article-title":"Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of the larynx and pharynx: report from the DAHANCA 2 study","volume":"16","author":"Overgaard","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib70","first-page":"509","article-title":"Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors","volume":"6","author":"Overgaard","year":"1994","journal-title":"Oncol Res"},{"key":"10.1016\/j.radonc.2007.04.002_bib71","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(97)00220-X","article-title":"A randomized double-blind phase III study of nimorazole as hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results from the Danish Head and Neck Cancer Study (DAHANCA). Protocol 5\u201385","volume":"46","author":"Overgaard","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib72","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(03)14361-9","article-title":"Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of the head and neck: DAHANCA 6 & 7 randomised controlled trial","volume":"362","author":"Overgaard","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2007.04.002_bib73","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1470-2045(05)70292-8","article-title":"Plasma osteopontin, hypoxia and response to the hypoxia sensitizer nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomises double-blind placebo-controlled trial","volume":"6","author":"Overgaard","year":"2005","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib74","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.1440","article-title":"Estimating the world cancer burden: Globocan 2000","volume":"94","author":"Parkin","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.radonc.2007.04.002_bib75","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3322\/canjclin.55.4.242","article-title":"TNM Staging of Cancers of the Head and Neck: striving for uniformity among diversity","volume":"55","author":"Patel","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2007.04.002_bib76","unstructured":"PDQ Editorial Board. Levels of Evidence for adult Cancer treatment studies: Strength of study design. National Cancer Institute. Website: www.cancer.gov.2006."},{"key":"10.1016\/j.radonc.2007.04.002_bib77","first-page":"125","article-title":"What is new in brachytherapy?","volume":"193","author":"Peiffert","year":"2006","journal-title":"Bull Cancer"},{"key":"10.1016\/j.radonc.2007.04.002_bib78","first-page":"403","article-title":"Applying radiobiological principles to combined modality treatment of head and neck cancer. The time factor","volume":"13","author":"Peters","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib79","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1200\/JCO.2006.07.4559","article-title":"American Society of Clinical Oncology Practice Guidelines for the use of larynx-preservation strategies in the treatment of laryngeal cancer","volume":"24","author":"Pfister","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib80","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-0","article-title":"Chemotherapy added to loco-regional treatment for head and neck squamous cell carcinoma: three meta-analyses of update individual data","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2007.04.002_bib81","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canrad.2004.11.002","article-title":"Individual patient data meta-analyses in head and neck carcinoma: what have we learnt?","volume":"9","author":"Pignon","year":"2005","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.radonc.2007.04.002_bib82","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/hed.20130","article-title":"Utility of positron emission tomography for the detection of disease in residual neck nodes after (chemo)radiotherapy in head and neck cancer","volume":"27","author":"Porceddu","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2007.04.002_bib83","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1634\/theoncologist.10-90003-11","article-title":"Paradigm shift in the treatment of Head and Neck Cancer: the role of neoadjuvant chemotherapy","volume":"10","author":"Posner","year":"2005","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2007.04.002_bib84","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1200\/JCO.2005.01.072","article-title":"Tirapazamine, cisplatin and radiation versus fluorouracil, cisplatin and radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group. (TROG 98.02)","volume":"23","author":"Rischin","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib85","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1200\/JCO.2005.05.2878","volume":"24","author":"Rischin","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib86","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1586\/14737140.5.3.501","article-title":"Head and Neck squamous cell carcinoma: optimizing the therapeutic index","volume":"5","author":"Rosenthal","year":"2005","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.radonc.2007.04.002_bib87","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ijrobp.2004.07.682","article-title":"Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter Phase III study","volume":"61","author":"Sanguineti","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib88","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.radonc.2004.11.004","article-title":"Intensity modulated radiotherapy for head and neck cancer: evidence for preserved salivary gland function","volume":"74","author":"Saarilahti","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib89","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.bjc.6602510","article-title":"State-of-the-art management of locally advanced head and neck cancer","volume":"92","author":"Seiwert","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2007.04.002_bib90","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3322\/canjclin.45.6.352","article-title":"Treatment of cancer of the head and neck","volume":"45","author":"Shah","year":"1995","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2007.04.002_bib91","first-page":"101","article-title":"Clinical radiobiology of glottic T1 squamous cell carcinoma","volume":"43","author":"Skladowski","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib92","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0360-3016(03)00207-4","article-title":"Postoperative concomitant irradiation and chemotherapy with mitomycin C and bleomycin for advanced head and neck carcinoma","volume":"56","author":"Smid","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib93","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.cad.0000198913.75571.13","article-title":"Recent new approaches to the treatment of head and neck cancer","volume":"17","author":"St John","year":"2006","journal-title":"AntiCancer Drugs"},{"key":"10.1016\/j.radonc.2007.04.002_bib94","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1200\/JCO.2004.00.3335","article-title":"Molecular classification identifies a subset of human Papillomavirus-associated oropharyngeal cancers with favorable prognosis","volume":"24","author":"Wenberger","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib95","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.radonc.2004.06.003","article-title":"Hyperfractionated accelerated radiochemotherapy (HFA-RCT) with mitomycin C for advanced head and neck cancer","volume":"73","author":"Widder","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib96","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.bjc.6602696","article-title":"Surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in stage III\u2013IV non metastatic squamous cell head and neck cancer: a randomized trial","volume":"8","author":"Soo","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2007.04.002_bib97","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.radonc.2005.07.007","article-title":"Randomized clinical trial on continuous 7-day-a week postoperative radiotherapy for high risk squamous cell head and neck cancer: a report on acute normal tissue reactions","volume":"77","author":"Suwinski","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib98","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0167-8140(95)01539-S","article-title":"The EORTC randomized trial of three fractions per day and misonidazole in advanced head and neck cancer: prognostic factors","volume":"35","author":"Van der Bogaert","year":"1995","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib99","doi-asserted-by":"crossref","unstructured":"VA Laryngeal cancer group study. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group. N Engl J Med 1991;324:1685\u201390.","DOI":"10.1056\/NEJM199106133242402"},{"key":"10.1016\/j.radonc.2007.04.002_bib100","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ijrobp.2004.05.049","article-title":"Investigation of relationship between change in loco-regional control and change in overall survival in randomized controlled trials or modified radiotherapy in head and neck cancer","volume":"60","author":"Wadsley","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2007.04.002_bib101","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/02841860310014886","article-title":"A systematic overview of radiation effects in head and neck cancer","volume":"42","author":"Zackrisson","year":"2003","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_bib102","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/jnci\/djh306","article-title":"Randomized Phase III trial of neoadjuvant chemotherapy in head and neck cancer: 10-year follow-up","volume":"96","author":"Zorat","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2007.04.002_bib103","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.radonc.2003.11.007","article-title":"Accelerated postoperative radiotherapy with weekly concomitant boost in patients with locally advanced head and neck cancer","volume":"70","author":"Zouhair","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_fr1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.radonc.2004.07.007","article-title":"Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results","volume":"72","author":"Baumann","year":"2004","journal-title":"Radioth Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_fr2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/ncponc0201","article-title":"Alteration of radiotherapy fractionation and concurrent chemotherapy: a new frontier in head and neck oncology?","volume":"2","author":"Bernier","year":"2005","journal-title":"Nature Clinical Practice Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_fr3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.radonc.2003.09.011","article-title":"CT-based delineation of lymph node levels and related CTVs in the node negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines","volume":"69","author":"Gregoire","year":"2003","journal-title":"Radioth Oncol"},{"issue":"suppl 6","key":"10.1016\/j.radonc.2007.04.002_fr4","doi-asserted-by":"crossref","first-page":"vi13","DOI":"10.1093\/annonc\/mdi453","article-title":"Promising new advances in head and neck radiotherapy","volume":"16","author":"Harari","year":"2005","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.radonc.2007.04.002_fr5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.semradonc.2004.04.002","article-title":"Clinical Studies of hypoxia modification in radiotherapy","volume":"14","author":"Kaanders","year":"2004","journal-title":"Sem Radiat Oncol"},{"key":"10.1016\/j.radonc.2007.04.002_fr6","unstructured":"National Comprehensive Cancer Network. Practice Guidelines:Head and Neck cancer, version 1.2006. http\/www.nccn.org\/physician-gls\/PDF\/head-and-neck-pdf."},{"key":"10.1016\/j.radonc.2007.04.002_fr7","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.bjc.6602510","article-title":"State-of-the-art management of locally advanced head and neck cancer","volume":"92","author":"Seiwert","year":"2005","journal-title":"Brit J Cancer"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814007001521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814007001521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T15:40:36Z","timestamp":1587483636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814007001521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":110,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0167814007001521"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2007.04.002","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}