{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:08:07Z","timestamp":1778281687740,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.radonc.2008.01.021","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T07:31:50Z","timestamp":1205393510000},"page":"300-303","source":"Crossref","is-referenced-by-count":30,"title":["Stevens\u2013Johnson syndrome and toxic epidermal necrolysis induced by amifostine during head and neck radiotherapy"],"prefix":"10.1016","volume":"87","author":[{"given":"Laurence","family":"Valeyrie-Allanore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Poulalhon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Fagot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Sekula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batya","family":"Davidovici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Sidoroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Mockenhaupt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2008.01.021_bib1","first-page":"189","article-title":"Amifostine. A novel cytoprotective agent","volume":"5","author":"Mc Cauley","year":"1997","journal-title":"Cancer Pract"},{"key":"10.1016\/j.radonc.2008.01.021_bib2","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1365-2133.2000.03847.x","article-title":"Two cases of Stevens\u2013Johnson syndrome: toxic epidermal necrolysis possibly induced by amifostine during radiotherapy","volume":"143","author":"Lale Atahan","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.radonc.2008.01.021_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ijrobp.2004.02.026","article-title":"Assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP)","volume":"60","author":"Boccia","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.01.021_bib4","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.ijrobp.2004.12.003","article-title":"In regard to Boccia et al.: assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP)","volume":"61","author":"Hicsonmez","year":"2005","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.radonc.2008.01.021_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.jid.5701033","article-title":"Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study","volume":"128","author":"Mockenhaupt","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.radonc.2008.01.021_bib6","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1056\/NEJM199411103311906","article-title":"Severe adverse cutaneous reactions to drugs","volume":"331","author":"Roujeau","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2008.01.021_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.129.1.92","article-title":"A clinical classification of cases of toxic epidermal necrolysis, Stevens\u2013Johnson syndrome and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.radonc.2008.01.021_bib8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1523-1747.2000.00061.x","article-title":"SCORTEN: a severity-of-illness score for toxic epidermal necrolysis","volume":"115","author":"Bastuji-Garin","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.radonc.2008.01.021_bib9","first-page":"2","article-title":"Amifostine: the preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies","volume":"123","author":"Capizzini","year":"1996","journal-title":"Semin Oncol"},{"key":"10.1016\/j.radonc.2008.01.021_bib10","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1200\/JCO.2000.18.19.3339","article-title":"Phase III randomized trial of amifostine as a radioprotector in head and neck cancer","volume":"18","author":"Brizel","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2008.01.021_bib11","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1200\/JCO.2000.18.11.2226","article-title":"Subcutaneous administration of amifostine during fractioned radiotherapy: a randomized phase II study","volume":"18","author":"Koukourakis","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2008.01.021_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1001\/archotol.132.2.141","article-title":"Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy","volume":"132","author":"Ozsahin","year":"2006","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.radonc.2008.01.021_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/sonc.2002.37346","article-title":"Phase II trial of subcutaneous amifostine in patients undergoing radiation therapy for head and neck cancer","volume":"29","author":"Anne","year":"2002","journal-title":"Semin Oncol"},{"key":"10.1016\/j.radonc.2008.01.021_bib14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/cncr.22020","article-title":"Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy 5 times weekly: a prospective randomized study in squamous cell head and neck cancer","volume":"107","author":"Jellema","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2008.01.021_bib15","first-page":"1953","article-title":"Influence of amifostine onlate radiation-toxicity in head and neck cancer \u2013 a follow-up study","volume":"27","author":"B\u00fcntzel","year":"2007","journal-title":"Anticancer Res"},{"key":"10.1016\/j.radonc.2008.01.021_bib16","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1097\/00002030-200109280-00014","article-title":"EuroSCAR-study group. Nevirapine and the risk of Stevens\u2013Johnson syndrome or toxic epidermal necrolysis","volume":"15","author":"Fagot","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.radonc.2008.01.021_bib17","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1056\/NEJM199512143332404","article-title":"Medication use and the risk of Stevens\u2013Johnson syndrome or toxic epidermal necrolysis","volume":"333","author":"Roujeau","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2008.01.021_bib18","first-page":"35","article-title":"Skin reactions to radiotherapy \u2013 a spectrum resembling erythema multiforme: case report and review of the literature","volume":"49","author":"Fleischer","year":"1992","journal-title":"Cutis"},{"key":"10.1016\/j.radonc.2008.01.021_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1439-0353.2005.04737.x","article-title":"EMPACT syndrome","volume":"3","author":"W\u00f6hrl","year":"2005","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.radonc.2008.01.021_bib20","first-page":"569","article-title":"EMPACT syndrome","volume":"3","author":"Mockenhaupt","year":"2005","journal-title":"J Dtsch Dermatol Ges"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814008000546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814008000546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T22:41:11Z","timestamp":1557355271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814008000546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0167814008000546"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2008.01.021","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}