{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:41:15Z","timestamp":1768790475784,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.radonc.2008.02.014","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T14:55:14Z","timestamp":1205592914000},"page":"173-180","source":"Crossref","is-referenced-by-count":26,"title":["A dose escalation study of hyperfractionated accelerated radiation delivered with integrated neck surgery (HARDWINS) for the management of advanced head and neck cancer"],"prefix":"10.1016","volume":"87","author":[{"given":"John","family":"Waldron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padraig","family":"Warde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Irish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melania","family":"Pintilie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Sellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Bayley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolie","family":"Ringash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Gullane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Witterick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2008.02.014_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0167-8140(97)00079-0","article-title":"Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial","volume":"44","author":"Horiot","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2008.02.014_bib2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(03)14361-9","article-title":"Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial","volume":"362","author":"Overgaard","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2008.02.014_bib3","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1200\/JCO.2006.08.057","article-title":"Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial","volume":"24","author":"Bourhis","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2008.02.014_bib4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ijrobp.2006.05.026","article-title":"Continuous accelerated 7-days-a-week radiotherapy for head-and-neck cancer: long-term results of phase III clinical trial","volume":"66","author":"Skladowski","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.02.014_bib5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(06)69121-6","article-title":"Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis","volume":"368","author":"Bourhis","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2008.02.014_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.radonc.2007.09.010","article-title":"Five year results of a randomized trial comparing hyperfractionated to conventional radiotherapy over four weeks in locally advanced head and neck cancer","volume":"85","author":"Cummings","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2008.02.014_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0167-8140(01)00429-7","article-title":"Consequential late effects in normal tissues","volume":"61","author":"Dorr","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2008.02.014_bib8","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0360-3016(01)02603-7","article-title":"Post-RT CT results as a predictive model for the necessity of planned post-RT neck dissection in patients with cervical metastatic disease from squamous cell carcinoma","volume":"52","author":"Ojiri","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.02.014_bib9","article-title":"Efficacy of neck treatment in patients with head and neck squamous cell carcinoma","author":"Buck","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2008.02.014_bib10","unstructured":"UICC TNM Classification of Malignant Tumours. 5th ed. New York: Wiley-Liss; 1997."},{"key":"10.1016\/j.radonc.2008.02.014_bib11","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.02.014_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2307\/2530297","article-title":"One-sample multiple testing procedure for phase II clinical trials","volume":"38","author":"Fleming","year":"1982","journal-title":"Biometrics"},{"key":"10.1016\/j.radonc.2008.02.014_bib13","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2294::AID-CNCR17>3.0.CO;2-S","article-title":"The performance status scale for head and neck cancer patients and the functional assessment of cancer therapy-head and neck scale. A study of utility and validity","volume":"77","author":"List","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2008.02.014_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.radonc.2007.12.028","article-title":"Hyperfractionated, accelerated radiotherapy for locally advanced head and neck cancer: Quality of life in a protective phase I\/II trial","volume":"87","author":"Ringash","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2008.02.014_bib15","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A class of K-sample tests for comparing the cumulative incidence of a competing risk","volume":"16","author":"Gray","year":"1988","journal-title":"Ann Stat"},{"key":"10.1016\/j.radonc.2008.02.014_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0360-3016(00)00663-5","article-title":"A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003","volume":"48","author":"Fu","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.02.014_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-8140(01)00347-4","article-title":"A randomised trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck: a Trans-Tasman Radiation Oncology Group Study","volume":"60","author":"Poulsen","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2008.02.014_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1634\/theoncologist.10-90003-11","article-title":"Paradigm shift in the treatment of head and neck cancer: the role of neoadjuvant chemotherapy","volume":"10","author":"Posner","year":"2005","journal-title":"Oncologist"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814008001102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814008001102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T01:27:30Z","timestamp":1546219650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814008001102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0167814008001102"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2008.02.014","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}