{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:04:13Z","timestamp":1782961453593,"version":"3.54.5"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.radonc.2008.04.011","type":"journal-article","created":{"date-parts":[[2008,5,24]],"date-time":"2008-05-24T09:07:25Z","timestamp":1211620045000},"page":"383-390","source":"Crossref","is-referenced-by-count":63,"title":["The effect of intensity-modulated radiotherapy and high dose rate brachytherapy on acute and late radiotherapy-related adverse events following chemoradiotherapy of anal cancer"],"prefix":"10.1016","volume":"87","author":[{"given":"Kauko","family":"Saarilahti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Arponen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Vaalavirta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Tenhunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2008.04.011_bib1","unstructured":"UICC TNM classification of malignant tumors: Lippincott, 1997."},{"key":"10.1016\/j.radonc.2008.04.011_bib2","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0360-3016(97)00390-8","article-title":"Impact of clinical and therapeutic factors on major late complications after radiotherapy with or without concomitant chemotherapy for anal carcinoma","volume":"39","author":"Allal","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(96)03409-5","article-title":"Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin","volume":"348","author":"Arnott","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2008.04.011_bib4","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1200\/JCO.1997.15.5.2040","volume":"15","author":"Bartelink","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2008.04.011_bib5","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0360-3016(02)03801-4","article-title":"Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies","volume":"54","author":"Brixey","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.radonc.2006.03.013","article-title":"Treatment of squamous cell anal cancer (SCACC) with pulsed dose rate brachytherapy: a retrospective study","volume":"79","author":"Bruna","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2008.04.011_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(04)01410-X","article-title":"Cancer of the anal canal","volume":"5","author":"Clark","year":"2004","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2008.04.011_bib8","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib9","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0360-3016(91)90265-6","article-title":"Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with and without mitomycin C","volume":"21","author":"Cummings","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0360-3016(93)90874-U","article-title":"Improved outcome with escalated radiation dosing for anal carcinoma","volume":"27","author":"Fung","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0360-3016(95)00223-5","article-title":"Ten-year results of chemoradiation for anal cancer: focus on late morbidity","volume":"34","author":"John","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijrobp.2005.02.030","article-title":"Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome","volume":"63","author":"Milano","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0360-3016(02)03804-X","article-title":"PET-guided IMRT for cervical carcinoma with positive para-aortic lymph nodes-a dose-escalation treatment planning study","volume":"55","author":"Mutic","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0360-3016(99)00330-2","article-title":"A simple method of obtaining equivalent doses for use in HDR brachytherapy","volume":"46","author":"Nag","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF02555448","article-title":"Epidermoid carcinoma of the anal canal. A series of 276 cases","volume":"30","author":"Papillon","year":"1987","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.radonc.2008.04.011_bib16","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0360-3016(89)90521-X","article-title":"Interstitial curietherapy in the conservative treatment of anal and rectal cancers","volume":"17","author":"Papillon","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0360-3016(96)00493-2","article-title":"Conservative treatment by irradiation of epidermoid cancers of the anal canal: prognostic factors of tumoral control and complications","volume":"37","author":"Peiffert","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0167-8140(93)90076-K","article-title":"Chemoradiation therapy for anal cancer: radiation plus continuous infusion of 5-fluorouracil with or without cisplatin","volume":"27","author":"Rich","year":"1993","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2008.04.011_bib19","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJM200003163421107","article-title":"Carcinoma of the anal canal","volume":"342","author":"Ryan","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2008.04.011_bib20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/02841860600849075","article-title":"Chemoradiotherapy of anal cancer is feasible in elderly patients: treatment results of mitomycin-5-FU combined with radiotherapy at Helsinki University Central Hospital 1992\u20132003","volume":"45","author":"Saarilahti","year":"2006","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2008.04.011_bib21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0360-3016(97)00814-6","article-title":"Interstitial iridium-192 implantation combined with external radiotherapy in anal cancer: ten years experience","volume":"40","author":"Sandhu","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2008.04.011_bib22","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/1097-0142(19910515)67:10<2462::AID-CNCR2820671012>3.0.CO;2-1","article-title":"Chemotherapy and radiation therapy for anal carcinoma. Survival and late morbidity","volume":"67","author":"Tanum","year":"1991","journal-title":"Cancer"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814008002314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814008002314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T10:23:10Z","timestamp":1545992590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814008002314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0167814008002314"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2008.04.011","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}