{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:11:31Z","timestamp":1781968291324,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.radonc.2010.04.021","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T01:37:08Z","timestamp":1275442628000},"page":"54-59","source":"Crossref","is-referenced-by-count":31,"title":["Dose\u2013response relations for stricture in the proximal oesophagus from head and neck radiotherapy"],"prefix":"10.1016","volume":"97","author":[{"given":"Eleftheria","family":"Alevronta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ahlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Mavroidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massoud","family":"al-Abany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Friesland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Tilikidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Laurell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt K.","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2010.04.021_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.radonc.2008.09.010","article-title":"Systematic review of dose\u2013volume parameters in the prediction of esophagitis in thoracic radiotherapy","volume":"91","author":"Rose","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.04.021_bib2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/cncr.11236","article-title":"Stricture of the proximal esophagus in head and neck carcinoma patients after radiotherapy","volume":"97","author":"Laurell","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2010.04.021_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/hed.21201","article-title":"Esophageal stricture after radiotherapy in patients with head and neck cancer: experience of a single institution over 2 treatment periods","author":"Ahlberg","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2010.04.021_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00405-007-0456-0","article-title":"Esophageal and pharyngeal strictures: report on 1, 862 endoscopic dilatations using the Savary-Gilliard technique","volume":"265","author":"Piotet","year":"2008","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.radonc.2010.04.021_bib5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S1808-8694(15)31029-6","article-title":"Oral complications of radiotherapy in the head and neck","volume":"72","author":"Jham","year":"2006","journal-title":"Braz J Otorhinolaryngol"},{"key":"10.1016\/j.radonc.2010.04.021_bib6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/02841860310012833","article-title":"Determination and clinical verification of dose\u2013response parameters for esophageal stricture from head and neck radiotherapy","volume":"42","author":"Mavroidis","year":"2003","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2010.04.021_bib7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ijrobp.2004.07.706","article-title":"Toward a definition of a threshold for harmless doses to the anal-sphincter region and the rectum","volume":"61","author":"Al-Abany","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.04.021_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0284186X.1997.11835454","article-title":"Specification of dose delivery in radiation therapy. Recommendation by the Nordic Association of Clinical Physics (NACP)","volume":"36","author":"Aaltonen","year":"1997","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2010.04.021_bib9","unstructured":"ICRU Report 62. Prescribing, recording and reporting photon beam therapy (Supplement to ICRU Report 50). Washington; 1999."},{"key":"10.1016\/j.radonc.2010.04.021_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00066-005-1313-y","article-title":"Dose\u2013response relations for anal sphincter regarding fecal leakage and blood or phlegm in stools after radiotherapy for prostate cancer. Radiobiological study of 65 consecutive patients","volume":"181","author":"Mavroidis","year":"2005","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2010.04.021_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.04.021_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0039-6109(16)42931-2","article-title":"The surgical management of the radiation-injured intestine","volume":"63","author":"Marks","year":"1983","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.radonc.2010.04.021_bib13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0002-9343(91)90665-K","article-title":"Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury","volume":"90","author":"Korsten","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/j.radonc.2010.04.021_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1053-4296(05)80045-1","article-title":"Brief summary of radiobiological principles in fractionated radiotherapy","volume":"2","author":"Fowler","year":"1992","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2010.04.021_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0037-198X(74)90009-1","article-title":"Complications of radiation therapy: the alimentary tract","volume":"9","author":"Roswit","year":"1974","journal-title":"Semin Roentgenol"},{"key":"10.1016\/j.radonc.2010.04.021_bib16","series-title":"Radiation induced injury to tissues, in fractionation in radiotherapy","year":"1987"},{"key":"10.1016\/j.radonc.2010.04.021_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09553009214552071","article-title":"Tumour and normal tissue responses to fractionated non-uniform dose delivery","volume":"62","author":"K\u00e4llman","year":"1992","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.radonc.2010.04.021_bib18","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0360-3016(90)90037-K","article-title":"Optimization of uncomplicated control for head and neck tumors","volume":"19","author":"\u00c5gren","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.04.021_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0360-3016(90)90155-D","article-title":"The biological effect of inhomogeneous dose distributions in fractionated radiotherapy","volume":"19","author":"Yaes","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.04.021_bib20","unstructured":"\u00c5gren A-K, K\u00e4llman P, Brahme A. Determination of the relative seriality of a tissue from its response to non-uniform dose delivery. In: Baltas D, editor. Modelling in clinical radiobiology. Germany: Albert Ludwigs University Freiburg; 1997."},{"key":"10.1016\/j.radonc.2010.04.021_bib21","unstructured":"Baltas D, Grassman J, editors. Volume effect & normal tissue responses. In: Baier K, Baltas, D, editors. Based on international workshop in W\u00fcrzburg, Freiburg, Germany: Albelt-Lundwings-University; 1997. p 155\u201389."},{"key":"10.1016\/j.radonc.2010.04.021_bib22","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1088\/0031-9155\/46\/10\/307","article-title":"Biologically effective uniform dose (D\u00af\u00af) for specification, report and comparison of dose response relations and treatment plans","volume":"46","author":"Mavroidis","year":"2001","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2010.04.021_bib23","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.ijrobp.2008.02.048","article-title":"Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy","volume":"72","author":"Caglar","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.04.021_bib24","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.ijrobp.2004.12.025","article-title":"Dose\u2013volumetric parameters of acute esophageal toxicity in patients with lung cancer treated with three-dimensional conformal radiotherapy","volume":"62","author":"Kim","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.04.021_bib25","series-title":"Quantification of the response of heterogeneous tumours and organized normal tissues to fractionated radiotherapy","author":"\u00c5gren","year":"1995"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781401000277X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781401000277X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T13:27:24Z","timestamp":1544448444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016781401000277X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S016781401000277X"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2010.04.021","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}