{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:15:43Z","timestamp":1771629343909,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.radonc.2010.05.019","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T07:05:18Z","timestamp":1277535918000},"page":"231-235","source":"Crossref","is-referenced-by-count":71,"title":["Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis"],"prefix":"10.1016","volume":"96","author":[{"given":"Hiroshi","family":"Imada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riwa","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Kandatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-etsu","family":"Mizoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yokosuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Tsujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2010.05.019_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-2007-1007117","article-title":"Epidemiology of primary liver cancer","volume":"19","author":"Bosch","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.radonc.2010.05.019_bib2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/1097-0142(196007\/08)13:4<714::AID-CNCR2820130411>3.0.CO;2-3","article-title":"Preliminary neoplasms of the liver. Results of radiation therapy","volume":"13","author":"Phillips","year":"1960","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2010.05.019_bib3","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0360-3016(89)90530-0","article-title":"194 Hepatocellular cancers treated by radiation and chemotherapy combinations: Toxicity and response: a Radiation Therapy Oncology Group study","volume":"17","author":"Stillwagon","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.05.019_bib4","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1200\/JCO.1993.11.7.1286","article-title":"Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy","volume":"11","author":"Robertson","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2010.05.019_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.radonc.2007.07.005","article-title":"Conformal radiation therapy for portal vein tumor thrombosis of hepatocellular carcinoma","volume":"84","author":"Toya","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.05.019_bib6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.radonc.2007.07.021","article-title":"Defining internal target volume (ITV) for hepatocellular carcinoma using four-dimensional CT","volume":"84","author":"Xi","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.05.019_bib7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.radonc.2007.12.006","article-title":"Application of active breathing control in 3-dimensional conformal radiation therapy for hepatocellular carcinoma: the feasibility and benefit","volume":"87","author":"Zhao","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.05.019_bib8","first-page":"40","article-title":"Increased efficacy of radiation therapy by use of proton beam","volume":"166","author":"Suit","year":"1990","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2010.05.019_bib9","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/0016-5085(94)90764-1","article-title":"A new, effective, and safe therapeutic option using proton irradiation for hepatocellular carcinoma","volume":"106","author":"Matsuzaki","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.radonc.2010.05.019_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4993\/acrt1992.7.9","article-title":"The efficacy of powerful proton radiotherapy for hepatocellular carcinoma-long term effects and QOL","volume":"7","author":"Matsuzaki","year":"1998","journal-title":"Ann Cancer Res Ther"},{"key":"10.1016\/j.radonc.2010.05.019_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/B978-0-12-035411-5.50013-7","article-title":"Heavy ion radiobiology: cellular studies","volume":"11","author":"Blakely","year":"1984","journal-title":"Adv Radiat Biol"},{"key":"10.1016\/j.radonc.2010.05.019_bib12","series-title":"Progress in radio-oncology","first-page":"643","article-title":"Future research strategy for heavy ion radiotherapy","author":"Castro","year":"1995"},{"key":"10.1016\/j.radonc.2010.05.019_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0375-9474(95)00144-P","article-title":"Performance of HIMAC","volume":"A588","author":"Sato","year":"1995","journal-title":"Nucl Phys"},{"key":"10.1016\/j.radonc.2010.05.019_bib14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2307\/3579446","article-title":"Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy","volume":"147","author":"Kanai","year":"1997","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2010.05.019_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0360-3016(98)00544-6","article-title":"Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy","volume":"44","author":"Kanai","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.05.019_bib16","first-page":"1","article-title":"Preliminary results of phase I\/II carbon ion therapy","volume":"13","author":"Tsujii","year":"1997","journal-title":"J Brachyther Int"},{"key":"10.1016\/j.radonc.2010.05.019_bib17","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.ijrobp.2004.01.032","article-title":"Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis","volume":"59","author":"Kato","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.05.019_bib18","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/S0167-8140(04)80012-4","article-title":"Overview of clinical experiences on carbon ion radiotherapy at NIRS","volume":"73","author":"Tsujii","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.05.019_bib19","first-page":"381A","article-title":"Phase II study of short-course carbon ion radiotherapy (52.8GyE\/4-fraction\/1-week) for hepatocellular carcinoma","volume":"42","author":"Kato","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.radonc.2010.05.019_bib20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1872-034X.2007.00119.x","article-title":"Report of the 17th nationwide follow-up survey of primary liver cancer in Japan","volume":"37","author":"Ikai","year":"2007","journal-title":"Hepatol Res"},{"key":"10.1016\/j.radonc.2010.05.019_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11864-005-0045-7","article-title":"Management of hepatocellular cancer","volume":"6","author":"Mulcahy","year":"2005","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.radonc.2010.05.019_bib22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJM199603143341104","article-title":"Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis","volume":"334","author":"Mazzaferro","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2010.05.019_bib23","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/hep.510300629","article-title":"Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation","volume":"30","author":"Llovet","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.radonc.2010.05.019_bib24","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1200\/JCO.2003.11.137","article-title":"The outcome of liver transplantation in patients with hepatocellular carcinoma in the United States between 1988 and 2001: 5-year survival has improved significantly with time","volume":"21","author":"Yoo","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2010.05.019_bib25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1067\/msy.2002.127545","article-title":"Radiofrequency ablation of liver tumors: influence of technique and tumor size","volume":"132","author":"Kuvshinoff","year":"2002","journal-title":"Surgery"},{"key":"10.1016\/j.radonc.2010.05.019_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2005.04.009","article-title":"A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma","volume":"129","author":"Shiina","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.radonc.2010.05.019_bib27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1053\/gast.1996.v110.pm8613057","article-title":"Microwave coagulation therapy for hepatocellular carcinoma","volume":"110","author":"Sato","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.radonc.2010.05.019_bib28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00000658-199804000-00018","article-title":"Radiofrequency ablation of porcine liver in vivo: effects of blood flow and treatment time on lesion size","volume":"227","author":"Patterson","year":"1998","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2010.05.019_bib29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1148\/radiol.2262012198","article-title":"Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study","volume":"226","author":"Livraghi","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2010.05.019_bib30","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2214\/AJR.05.2079","article-title":"Radiofrequency ablation of hepatocellular carcinoma: correlation between local tumor progression after ablation and ablative margin","volume":"188","author":"Nakazawa","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.radonc.2010.05.019_bib31","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1111\/j.1440-1746.2007.05091.x","article-title":"Intraductal chilled saline perfusion to prevent bile duct injury during percutaneous radiofrequency ablation for hepatocellular carcinoma","volume":"23","author":"Ohnishi","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.radonc.2010.05.019_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","article-title":"Prognosis of hepatocellular carcinoma: the BCLC staging classification","volume":"19","author":"Llovet","year":"1999","journal-title":"Semin liver Dis"},{"key":"10.1016\/j.radonc.2010.05.019_bib33","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","article-title":"Hepatocellular carcinoma","volume":"362","author":"Llovet","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2010.05.019_bib34","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0360-3016(00)00524-1","article-title":"Respiratory gated irradiation system for heavy-ion radiotherapy","volume":"47","author":"Minohara","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.05.019_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0360-3016(00)00568-X","article-title":"Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams","volume":"48","author":"Suzuki","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.05.019_bib36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/01.sla.0000171307.37401.db","article-title":"Prognostic impact of anatomic resection for hepatocellular carcinoma","volume":"242","author":"Hasegawa","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2010.05.019_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1148\/radiology.217.1.r00se02119","article-title":"Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply","volume":"217","author":"Rossi","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2010.05.019_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2214\/ajr.176.1.1760003","article-title":"Radiofrequency ablation of the liver: current status","volume":"176","author":"McGhana","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.radonc.2010.05.019_bib39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2214\/ajr.176.1.1760187","article-title":"Radiofrequency liver ablation: experimental comparative study of water-cooled versus expandable systems","volume":"176","author":"de Baere","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.radonc.2010.05.019_bib40","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ijrobp.2007.09.056","article-title":"Proton beam therapy for hepatocellular carcinoma adjacent to the prota hepatis","volume":"71","author":"Mizumoto","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814010003373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814010003373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T09:17:44Z","timestamp":1559207864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814010003373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0167814010003373"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2010.05.019","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}