{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:12:09Z","timestamp":1792059129479,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.radonc.2010.10.010","type":"journal-article","created":{"date-parts":[[2010,11,27]],"date-time":"2010-11-27T04:30:59Z","timestamp":1290832259000},"page":"63-67","source":"Crossref","is-referenced-by-count":61,"title":["Carbon ion radiotherapy performed as re-irradiation using active beam delivery in patients with tumors of the brain, skull base and sacral region"],"prefix":"10.1016","volume":"98","author":[{"given":"Stephanie E.","family":"Combs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Kalbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nikoghosyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ackermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"J\u00e4kel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Haberer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2010.10.010_b0005","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1200\/JCO.2001.19.15.3547","article-title":"High efficacy of fractionated stereotactic radiotherapy of large base-of-skull meningiomas: long-term results","volume":"19","author":"Debus","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0360-3016(02)03809-9","article-title":"Intensity modulated radiotherapy (IMRT) for recurrent, residual, or untreated skull-base meningiomas: preliminary clinical experience","volume":"55","author":"Pirzkall","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000061325","article-title":"Inverse planning and intensity-modulated radiotherapy in patients with prostate cancer","volume":"36","author":"Debus","year":"2002","journal-title":"Front Radiat Ther Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02753842","article-title":"[Stereotactic one-time irradiation (radiosurgery). The methods, indications and results]","volume":"175","author":"Debus","year":"1999","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2010.10.010_b0025","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/cncr.21158","article-title":"Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques","volume":"104","author":"Schulz-Ertner","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2010.10.010_b0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11060-008-9607-4","article-title":"Radiochemotherapy with temozolomide as re-irradiation using high precision fractionated stereotactic radiotherapy (FSRT) in patients with recurrent gliomas","volume":"89","author":"Combs","year":"2008","journal-title":"J Neurooncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11060-004-2029-z","article-title":"Recurrent low-grade gliomas: the role of fractionated stereotactic re-irradiation","volume":"71","author":"Combs","year":"2005","journal-title":"J Neurooncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11060-004-2463-y","article-title":"Stereotactically guided fractionated re-irradiation in recurrent glioblastoma multiforme","volume":"74","author":"Combs","year":"2005","journal-title":"J Neurooncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0045","doi-asserted-by":"crossref","first-page":"8863","DOI":"10.1200\/JCO.2005.03.4157","article-title":"Efficacy of fractionated stereotactic reirradiation in recurrent gliomas: long-term results in 172 patients treated in a single institution","volume":"23","author":"Combs","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0050","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/1471-2407-6-222","article-title":"Local radiotherapeutic management of ependymomas with fractionated stereotactic radiotherapy (FSRT)","volume":"6","author":"Combs","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2010.10.010_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2009.07.1727","article-title":"Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord","author":"Choi","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0060","article-title":"Hyperfractionated accelerated radiotherapy for rectal cancer in patients with prior pelvic irradiation","author":"Das","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1748-717X-4-55","article-title":"Reirradiation to the abdomen for gastrointestinal malignancies","volume":"4","author":"Haque","year":"2009","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0360-3016(89)90452-5","article-title":"Effect of dose rate on local control and complications in the reirradiation of head and neck tumors with interstitial iridium-192","volume":"17","author":"Fontanesi","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1288\/00005537-198701000-00016","article-title":"Reirradiation of recurrent head and neck cancers","volume":"97","author":"Emami","year":"1987","journal-title":"Laryngoscope"},{"key":"10.1016\/j.radonc.2010.10.010_b0080","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00000421-198810000-00007","article-title":"Reirradiation of recurrent tumors in the head and neck","volume":"11","author":"Pomp","year":"1988","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/COC.0b013e3181aacba5","article-title":"Fractionated stereotactic body radiation therapy in the treatment of previously-irradiated recurrent head and neck carcinoma: updated report of the University of Pittsburgh experience","volume":"1","author":"Rwigema","year":"2009","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0090","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/153303460600500510","article-title":"Frameless stereotactic radiosurgery for recurrent head and neck carcinoma","volume":"5","author":"Voynov","year":"2006","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.radonc.2010.10.010_b0095","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ijrobp.2008.12.075","article-title":"Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial","volume":"75","author":"Heron","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1471-2407-7-167","article-title":"Radiotherapeutic alternatives for previously irradiated recurrent gliomas","volume":"7","author":"Combs","year":"2007","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2010.10.010_b0105","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ijrobp.2008.02.037","article-title":"Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo","volume":"71","author":"Elsasser","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0110","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/rpd\/ncl426","article-title":"Test of the local effect model using clinical data: tumour control probability for lung tumours after treatment with carbon ion beams","volume":"122","author":"Scholz","year":"2006","journal-title":"Radiat Prot Dosimetry"},{"key":"10.1016\/j.radonc.2010.10.010_b0115","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1200\/JCO.2006.09.7816","article-title":"Particle radiation therapy using proton and heavier ion beams","volume":"25","author":"Schulz-Ertner","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0167-8140(02)00153-6","article-title":"Acute radiation-induced toxicity of heavy ion radiotherapy delivered with intensity modulated pencil beam scanning in patients with base of skull tumors","volume":"64","author":"Schulz-Ertner","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0125","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/cncr.24153","article-title":"Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base","volume":"115","author":"Combs","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2010.10.010_b0130","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijrobp.2006.08.027","article-title":"Carbon ion radiotherapy of skull base chondrosarcomas","volume":"67","author":"Schulz-Ertner","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0135","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2006.12.059","article-title":"Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas","volume":"68","author":"Schulz-Ertner","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0360-3016(03)01439-1","article-title":"Evaluation of therapeutic potential of heavy ion therapy for patients with locally advanced prostate cancer","volume":"58","author":"Nikoghosyan","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0145","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0360-3016(02)04511-X","article-title":"Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas","volume":"56","author":"Schulz-Ertner","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0150","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0168-9002(93)91335-K","article-title":"Magnetic scanning system for heavy ion therapy","volume":"A330","author":"Haberer","year":"1993","journal-title":"Nucl Instrum Methods Phys Res"},{"key":"10.1016\/j.radonc.2010.10.010_b0155","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/S0167-8140(04)80022-7","article-title":"Treatment planning for carbon ion radiotherapy in Germany: review of clinical trials and treatment planning studies","volume":"73","author":"Jakel","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0160","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1088\/0031-9155\/46\/4\/314","article-title":"Treatment planning for heavy ion radiotherapy: clinical implementation and application","volume":"46","author":"Jakel","year":"2001","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2010.10.010_b0165","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/S0167-8140(04)80021-5","article-title":"Treatment planning for scanned ion beams","volume":"73","author":"Kramer","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2010.10.010_b0170","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1088\/0031-9155\/45\/11\/313","article-title":"Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization","volume":"45","author":"Kramer","year":"2000","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2010.10.010_b0175","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1259\/0007-1285-21-249-464","article-title":"Radiation myelitis of the cervical spinal cord","volume":"21","author":"Boden","year":"1948","journal-title":"Br J Radiol"},{"key":"10.1016\/j.radonc.2010.10.010_b0180","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0360-3016(01)01599-1","article-title":"Extent and kinetics of recovery of occult spinal cord injury","volume":"50","author":"Ang","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0185","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0360-3016(97)00364-7","article-title":"Brainstem tolerance to conformal radiotherapy of skull base tumors","volume":"39","author":"Debus","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2010.10.010_b0190","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1667\/3063","article-title":"Radiation tolerance of the rat spinal cord after single and split doses of photons and carbon ions","volume":"160","author":"Debus","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2010.10.010_b0195","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.ijrobp.2006.08.045","article-title":"Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: experimental results and clinical implications","volume":"66","author":"Karger","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814010006055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814010006055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T10:24:16Z","timestamp":1544091856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814010006055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0167814010006055"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2010.10.010","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}