{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:56:50Z","timestamp":1791068210809,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.radonc.2011.05.008","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T10:06:53Z","timestamp":1307354813000},"page":"101-107","source":"Crossref","is-referenced-by-count":34,"title":["Dose\u2013volume analysis of locoregional recurrences in head and neck IMRT, as determined by deformable registration: A prospective multi-institutional trial"],"prefix":"10.1016","volume":"99","author":[{"given":"Amira","family":"Shakam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufus","family":"Scrimger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Parliament","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Colin","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"El-Gayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Cadman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Warkentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Skarsgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2011.05.008_b0005","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0010","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1368-8375(00)00063-4","article-title":"Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy","volume":"37","author":"Henson","year":"2001","journal-title":"Oral Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0167-8140(01)00449-2","article-title":"Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques","volume":"61","author":"Chao","year":"2001","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0167-8140(02)00172-X","article-title":"Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome?","volume":"64","author":"Claus","year":"2002","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.coc.0000258081.70643.3d","article-title":"Correlation between saliva production and quality of life measurements in head and neck cancer patients treated with intensity-modulated radiotherapy","volume":"30","author":"Scrimger","year":"2007","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0030","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.ijrobp.2009.04.011","article-title":"Multi-Institutional trial of accelerated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00\u201322)","volume":"76","author":"Eisbruch","year":"2010","journal-title":"Int. J. Rad. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0035","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.ijrobp.2009.04.006","article-title":"Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure","volume":"76","author":"Daly","year":"2010","journal-title":"Int. J. Rad. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0040","first-page":"500S","article-title":"Impact of intensity-modulated radiotherapy (IMRT) on salivary gland function in early-stage nasopharyngeal carcinoma (NPC) patients: a prospective randomized study","volume":"23","author":"Kam","year":"2005","journal-title":"Proc. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0045","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ijrobp.2006.06.013","article-title":"Xerostomia and quality of life after intensity-modulated radiotherapy vs Conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial","volume":"66","author":"Pow","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0050","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/hed.2880120302","article-title":"Patterns of cervical node metastasis from squamous carcinoma of the oropharynx and hypopharynx","volume":"12","author":"Candela","year":"1990","journal-title":"Head and Neck"},{"key":"10.1016\/j.radonc.2011.05.008_b0055","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/archotol.1990.01870040054013","article-title":"Patterns of cervical node metastasis from squamous carcinoma of the larynx","volume":"116","author":"Candela","year":"1990","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.radonc.2011.05.008_b0060","series-title":"Management of the neck for squamous cell carcinoma. Management of head and neck cancer. A multidisciplinary approach","author":"Million","year":"1994"},{"key":"10.1016\/j.radonc.2011.05.008_b0065","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/srao.2002.32435","article-title":"Intensity-modulated radiation therapy for head and neck cancer: emphasis on the selection and delineation of the targets","volume":"12","author":"Eisbruch","year":"2002","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0070","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0360-3016(03)00719-3","article-title":"Location of cervical lymph node metastases in oropharyngeal and hypopharyngeal carcinoma: implications for cranial border of elective nodal target volumes","volume":"58","author":"Braam","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0075","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(00)00202-4","article-title":"Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience","volume":"56","author":"Gr\u00e9goire","year":"2000","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0080","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.radonc.2003.09.011","article-title":"CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines","volume":"69","author":"Gr\u00e9goire","year":"2003","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2006.03.009","article-title":"Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck","volume":"79","author":"Gregoire","year":"2006","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0090","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0360-3016(98)00148-5","article-title":"Clinical variability of target volume description in conformal radiotherapy planning","volume":"41","author":"Logue","year":"1998","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0095","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1118\/1.1568978","article-title":"CERR: a computational environment for radiotherapy research","volume":"30","author":"Deasy","year":"2003","journal-title":"Med. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0100","unstructured":"National Library of Medicine of the National Institutes of Health Insight Segmentation and Registration Toolkit. http:\/\/www.itk.org."},{"key":"10.1016\/j.radonc.2011.05.008_b0105","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1361-8415(98)80022-4","article-title":"Image matching as a diffusion process: an analogy with Maxwell\u2019s demons","volume":"2","author":"Thirion","year":"1998","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.radonc.2011.05.008_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2008.04.010","article-title":"Comparison of 12 deformable registration strategies in adaptive radiation therapy for the treatment of head and neck tumors","volume":"89","author":"Castadot","year":"2008","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0115","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijrobp.2004.07.677","article-title":"Implementation and validation of a three-dimensional deformable registration algorithm for targeted prostate cancer radiotherapy","volume":"61","author":"Wang","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00066-007-1663-8","article-title":"Locoregional failure analysis in head-and-neck cancer patients treated with IMRT","volume":"183","author":"Studer","year":"2007","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2011.05.008_b0125","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.ijrobp.2005.07.127","article-title":"Patterns of failure in patients receiving intensity-modulated radiation therapy (IMRT) for head, neck cancer [Abstract]","volume":"36","author":"Thorstad","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0130","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0360-3016(99)00550-7","article-title":"Patterns of locoregional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer","volume":"46","author":"Dawson","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0135","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0360-3016(02)03940-8","article-title":"Patterns of failure in patients receiving definitive and postoperative IMRT for head and neck cancer","volume":"55","author":"Chao","year":"2003","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.radonc.2010.03.007","article-title":"Assessment by a deformable registration method of the volumetric and positional changes of target volumes and organs at risk in pharyngo-laryngeal tumors treated with concomitant chemo-radiation","volume":"95","author":"Castadot","year":"2010","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2008.07.006","article-title":"Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration","volume":"89","author":"Lee","year":"2008","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2010.05.003","article-title":"Improving target delineation on 4-dimensional CT scans in stage I NSCLC using a deformable registration tool","volume":"96","author":"Van Dam","year":"2010","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0155","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.radonc.2010.12.007","article-title":"The evaluation of a deformable image registration segmentation technique for semi-automating internal target volume (ITV) production from 4DCT images of lung stereotactic body radiotherapy (SBRT) patients","volume":"98","author":"Speight","year":"2011","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2008.04.010","article-title":"Comparison of 12 deformable registration strategies in adaptive radiation therapy for the treatment of head and neck tumors","volume":"89","author":"Castadot","year":"2008","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0165","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijrobp.2003.10.032","article-title":"Recurrences near the base of skull following IMRT of head and neck cancer: implications for target delineation in the high neck and for parotid gland sparing","volume":"59","author":"Eisbruch","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0170","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijrobp.2007.10.010","article-title":"Patterns of failure and toxicity after intensity-modulated radiotherapy for head and neck cancer","volume":"71","author":"Schoenfeld","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0175","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ijrobp.2008.01.027","article-title":"Patterns of locoregional failure after exclusive IMRT for oropharyngeal carcinoma","volume":"72","author":"Sanguineti","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0180","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijrobp.2005.02.025","article-title":"Intensity-modulated radiation treatment for head-and-neck squamous cell carcinoma\u2013the University of Iowa experience","volume":"63","author":"Yao","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0360-3016(02)02724-4","article-title":"Intensity modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience","volume":"53","author":"Lee","year":"2002","journal-title":"Int. J. Rad. Oncol. Biol. Phys."},{"key":"10.1016\/j.radonc.2011.05.008_b0190","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0167-8140(95)01584-4","article-title":"Where exactly does failure occur after radiation in head and neck cancer?","volume":"37","author":"Pigott","year":"1995","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.radonc.2011.05.008_b0195","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/030089168306900314","article-title":"Recurrences in the soft tissues of the neck after surgery or radiotherapy plus surgery on regional lymph nodes in patients bearing carcinomas of the head and neck","volume":"69","author":"Basso-Ricci","year":"1983","journal-title":"Tumori"},{"key":"10.1016\/j.radonc.2011.05.008_b0200","first-page":"18S","article-title":"First results of a phase III multicenter randomized controlled trial of intensity modulated (IMRT) versus conventional radiotherapy (RT) in head, neck cancer","volume":"27","author":"Nutting","year":"2010","journal-title":"J. Clin. Oncol."}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814011002003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814011002003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T12:41:22Z","timestamp":1560256882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814011002003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0167814011002003"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2011.05.008","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}