{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:32:58Z","timestamp":1792092778435,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.radonc.2011.05.028","type":"journal-article","created":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T20:25:58Z","timestamp":1308601558000},"page":"376-382","source":"Crossref","is-referenced-by-count":150,"title":["Comparison of intensity-modulated radiotherapy, adaptive radiotherapy, proton radiotherapy, and adaptive proton radiotherapy for treatment of locally advanced head and neck cancer"],"prefix":"10.1016","volume":"101","author":[{"suffix":"II","given":"Charles B.","family":"Simone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu D.","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ondos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Belard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2011.05.028_b0005","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1093\/jnci\/91.24.2081","article-title":"Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma","volume":"91","author":"Calais","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2011.05.028_b0010","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.ijrobp.2005.05.004","article-title":"Voice and swallowing outcomes of an organ-preservation trial for advanced laryngeal cancer","volume":"63","author":"Fung","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.radonc.2004.09.015","article-title":"Dose\u2013response relationships within the parotid gland after radiotherapy for head and neck cancer","volume":"73","author":"Bussels","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0020","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijrobp.2006.09.021","article-title":"The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy","volume":"67","author":"Li","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0025","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ijrobp.2004.12.076","article-title":"Dose\u2013volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy","volume":"62","author":"Blanco","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0030","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.ijrobp.2007.01.047","article-title":"Radiation doses to structures within and adjacent to the larynx are correlated with long-term diet- and speech-related quality of life","volume":"68","author":"Dornfeld","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0035","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijrobp.2008.01.012","article-title":"Beam path toxicities to non-target structures during intensity-modulated radiation therapy for head and neck cancer","volume":"72","author":"Rosenthal","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.radonc.2006.12.004","article-title":"Quality of interstitial PDR-brachytherapy-implants of head-and-neck-cancers: predictive factors for local control and late toxicity?","volume":"82","author":"Melzner","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0045","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.radonc.2007.04.002","article-title":"Evidence-based radiation oncology in head and neck squamous cell carcinoma","volume":"85","author":"Corv\u00f2","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0050","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/1097-0142(19830301)51:5<811::AID-CNCR2820510511>3.0.CO;2-M","article-title":"Nutritional consequences of the radiotherapy of head and neck cancer","volume":"51","author":"Chencharick","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2011.05.028_b0055","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0360-3016(01)01531-0","article-title":"Implications of quantitative tumor and nodal regression rates for nasopharyngeal carcinomas after 45Gy of radiotherapy","volume":"50","author":"Fang","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0060","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ijrobp.2009.04.047","article-title":"Adaptive replanning strategies accounting for shrinkage in head and neck IMRT","volume":"75","author":"Wu","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0065","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.ijrobp.2003.12.024","article-title":"Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT\/linear accelerator system","volume":"59","author":"Barker","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0070","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijrobp.2005.07.957","article-title":"Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer","volume":"64","author":"Hansen","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0075","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.radonc.2010.03.007","article-title":"Assessment by a deformable registration method of the volumetric and positional changes of target volumes and organs at risk in pharyngo-laryngeal tumors treated with concomitant chemo-radiation","volume":"95","author":"Castadot","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0080","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.radonc.2009.12.014","article-title":"A two-variable linear model of parotid shrinkage during IMRT for head and neck cancer","volume":"94","author":"Broggi","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2008.07.006","article-title":"Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration","volume":"89","author":"Lee","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0090","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.ijrobp.2007.07.2345","article-title":"Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get?","volume":"69","author":"O\u2019Daniel","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(98)00092-9","article-title":"Relative biological effectiveness of proton beams in clinical therapy","volume":"50","author":"Gerweck","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0100","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ijrobp.2004.09.064","article-title":"Proton radiation for treatment of cancer of the oropharynx: early experience at Loma Linda University Medical Center using a concomitant boost technique","volume":"62","author":"Slater","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0105","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0360-3016(00)01555-8","article-title":"Methodologies and tools for proton beam design for lung tumors","volume":"49","author":"Moyers","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0110","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ncpcardio1307","article-title":"From randomized trials to registry studies: translating data into clinical information","volume":"5","author":"Brown","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1016\/j.radonc.2011.05.028_b0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semradonc.2008.09.008","article-title":"Balancing risk and reward in target delineation for highly conformal radiotherapy in head and neck cancer","volume":"19","author":"Eisbruch","year":"2009","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.radonc.2010.05.009","article-title":"Evaluation of the radiobiological impact of anatomic modifications during radiation therapy for head and neck cancer: can we simply summate the dose?","volume":"96","author":"Orban de Xivry","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0125","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hed.10373","article-title":"Neoadjuvant radiochemotherapy of oral cavity and oropharyngeal cancer: evaluation of tumor response by CT differs from histopathologic response assessment in a significant fraction of patients","volume":"26","author":"Klug","year":"2004","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2011.05.028_b0130","unstructured":"ClinicalTrials.gov, \u201cSearch for Clinical Trials,\u201d 11 May 2010, <http:\/\/clinicaltrials.gov\/> [11.05.2010]."},{"key":"10.1016\/j.radonc.2011.05.028_b0135","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijrobp.2008.11.059","article-title":"Clinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancer","volume":"75","author":"Salama","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.radonc.2010.10.027","article-title":"Helical tomotherapy and intensity modulated proton therapy in the treatment of early stage prostate cancer: a treatment planning comparison","volume":"98","author":"Schwarz","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0145","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.radonc.2010.09.006","article-title":"Double-scattered proton-based stereotactic body radiotherapy for stage I lung cancer: A dosimetric comparison with photon-based stereotactic body radiotherapy","volume":"97","author":"Hoppe","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0150","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.radonc.2010.05.007","article-title":"Boosting the tumor bed from deep-seated tumors in early-stage breast cancer: A planning study between electron, photon, and proton beams","volume":"96","author":"Toscas","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0155","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0167-8140(01)00403-0","article-title":"A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours","volume":"61","author":"Cozzi","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.radonc.2004.03.018","article-title":"Potential outcomes of modalities and techniques in radiotherapy for patients with hypopharyngeal carcinoma","volume":"72","author":"Johansson","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0165","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/0360-3016(89)90970-X","article-title":"Proton therapy for carcinoma of the nasopharynx: a study in comparative treatment planning","volume":"16","author":"Brown","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.028_b0170","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1748-717X-3-4","article-title":"Intensity-modulated radiotherapy of nasopharyngeal carcinoma: a comparative treatment planning study of photons, protons","volume":"3","author":"Taheri-Kadkhoda","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0175","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1278-3218(02)00222-6","article-title":"Comparison with dose\u2013volume histograms of two conformal irradiation techniques used for the treatment of T2N0M0 nasopharyngeal cancer, one with association of photons and protons and another with photons alone","volume":"6","author":"No\u00ebl","year":"2002","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.radonc.2011.05.028_b0180","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.radonc.2006.07.025","article-title":"Intensity modulated photon and proton therapy for the treatment of head and neck tumors","volume":"80","author":"Steneker","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.028_b0185","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.ijrobp.2008.03.007","article-title":"Effects of interfractional motion and anatomic changes on proton therapy dose distribution in lung cancer","volume":"72","author":"Hui","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814011002210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814011002210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T23:53:20Z","timestamp":1543708400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814011002210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0167814011002210"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2011.05.028","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}