{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:43:37Z","timestamp":1774925017114,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":660,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"crossref","award":["UM 2008-4068"],"award-info":[{"award-number":["UM 2008-4068"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009164","name":"Transnational University Limburg","doi-asserted-by":"crossref","award":["30943045T"],"award-info":[{"award-number":["30943045T"]}],"id":[{"id":"10.13039\/501100009164","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long Term Care","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Terry Fox New Frontiers Research Program","award":["PPG09-020005"],"award-info":[{"award-number":["PPG09-020005"]}]},{"name":"Ontario Institute for Cancer Research"},{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute for Health Research","doi-asserted-by":"crossref","award":["201592"],"award-info":[{"award-number":["201592"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU 7th framework program","award":["222741"],"award-info":[{"award-number":["222741"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.radonc.2011.05.059","type":"journal-article","created":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T20:05:34Z","timestamp":1309550734000},"page":"190-197","source":"Crossref","is-referenced-by-count":38,"title":["Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T"],"prefix":"10.1016","volume":"101","author":[{"given":"Chantal H.M.A.","family":"Ramaekers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Twan","family":"van den Beucken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaqil","family":"Kassam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Thoms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Bristow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradly G.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2011.05.059_b0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrc1367","article-title":"Exploiting tumour hypoxia in cancer treatment","volume":"4","author":"Brown","year":"2004","journal-title":"Nat Rev"},{"key":"10.1016\/j.radonc.2011.05.059_b0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2005.06.038","article-title":"Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study","volume":"77","author":"Nordsmark","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0015","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0360-3016(97)00101-6","article-title":"Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck","volume":"38","author":"Brizel","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2011.05.059_b0020","first-page":"4509","article-title":"Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix","volume":"56","author":"Hockel","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2011.05.059_b0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc704","article-title":"Hypoxia \u2013 a key regulatory factor in tumour growth","volume":"2","author":"Harris","year":"2002","journal-title":"Nat Rev"},{"key":"10.1016\/j.radonc.2011.05.059_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2011.03.004","article-title":"Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck \u2013 a systematic review and meta-analysis","author":"Overgaard","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.radonc.2010.04.022","article-title":"The role of human papillomavirus in head and neck cancer and the impact on radiotherapy outcome","volume":"95","author":"Lassen","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1172\/JCI13374","article-title":"Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance","volume":"108","author":"Semenza","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.radonc.2011.05.059_b0045","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/sj.bjc.6690586","article-title":"Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis","volume":"80","author":"Rofstad","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2011.05.059_b0050","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1054\/bjoc.2001.1743","article-title":"Relationship of hypoxia to metastatic ability in rodent tumours","volume":"84","author":"De Jaeger","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2011.05.059_b0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0167-8140(98)00044-9","article-title":"Oxygenation predicts radiation response and survival in patients with cervix cancer","volume":"48","author":"Fyles","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0060","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.radonc.2009.08.017","article-title":"Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3","volume":"92","author":"Mujcic","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0065","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.radonc.2009.06.029","article-title":"Autophagy is required during cycling hypoxia to lower production of reactive oxygen species","volume":"92","author":"Rouschop","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0070","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.radonc.2009.06.018","article-title":"Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment","volume":"92","author":"van den Beucken","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0075","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nrc2501","article-title":"Hypoxia signalling through mTOR and the unfolded protein response in cancer","volume":"8","author":"Wouters","year":"2008","journal-title":"Nat Rev"},{"key":"10.1016\/j.radonc.2011.05.059_b0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.drup.2003.12.004","article-title":"Targeting hypoxia tolerance in cancer","volume":"7","author":"Wouters","year":"2004","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.radonc.2011.05.059_b0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/379088a0","article-title":"Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours","volume":"379","author":"Graeber","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.radonc.2011.05.059_b0090","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrc2344","article-title":"Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability","volume":"8","author":"Bristow","year":"2008","journal-title":"Nat Rev"},{"key":"10.1016\/j.radonc.2011.05.059_b0095","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1158\/0008-5472.CAN-05-0713","article-title":"Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression","volume":"65","author":"Shahrzad","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2011.05.059_b0100","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1128\/MCB.23.9.3265-3273.2003","article-title":"Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells","volume":"23","author":"Mihaylova","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.radonc.2011.05.059_b0105","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1634\/stemcells.2007-1016","article-title":"Hypoxia causes downregulation of mismatch repair system and genomic instability in stem cells","volume":"26","author":"Rodriguez-Jimenez","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.radonc.2011.05.059_b0110","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.molcel.2005.02.015","article-title":"HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression","volume":"17","author":"Koshiji","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.radonc.2011.05.059_b0115","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.radonc.2005.06.025","article-title":"Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells","volume":"76","author":"Meng","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0120","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/0008-5472.CAN-07-5472","article-title":"Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance","volume":"68","author":"Chan","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2011.05.059_b0125","doi-asserted-by":"crossref","first-page":"11597","DOI":"10.1158\/0008-5472.CAN-05-2119","article-title":"Hypoxia-induced down-regulation of BRCA1 expression by E2Fs","volume":"65","author":"Bindra","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2011.05.059_b0130","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1038\/sj.onc.1210001","article-title":"Repression of RAD51 gene expression by E2F4\/p130 complexes in hypoxia","volume":"26","author":"Bindra","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.radonc.2011.05.059_b0135","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/35076590","article-title":"The emerging genetic and molecular basis of Fanconi anaemia","volume":"2","author":"Joenje","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.radonc.2011.05.059_b0140","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrc970","article-title":"The Fanconi anaemia\/BRCA pathway","volume":"3","author":"D\u2019Andrea","year":"2003","journal-title":"Nat Rev"},{"key":"10.1016\/j.radonc.2011.05.059_b0145","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1182\/blood-2005-10-4240","article-title":"Molecular pathogenesis of Fanconi anemia: recent progress","volume":"107","author":"Taniguchi","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.radonc.2011.05.059_b0150","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1097-2765(01)00173-3","article-title":"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway","volume":"7","author":"Garcia-Higuera","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.radonc.2011.05.059_b0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2443.2007.01054.x","article-title":"A requirement of FancL and FancD2 monoubiquitination in DNA repair","volume":"12","author":"Seki","year":"2007","journal-title":"Genes Cells"},{"key":"10.1016\/j.radonc.2011.05.059_b0160","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.molcel.2007.01.003","article-title":"Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM","volume":"25","author":"Ciccia","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.radonc.2011.05.059_b0165","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/sj.emboj.7601666","article-title":"FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway","volume":"26","author":"Ling","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.radonc.2011.05.059_b0170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molcel.2006.06.024","article-title":"UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation","volume":"23","author":"Machida","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.radonc.2011.05.059_b0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2007.03.009","article-title":"Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair","volume":"129","author":"Smogorzewska","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.radonc.2011.05.059_b0180","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1182\/blood-2002-01-0278","article-title":"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51","volume":"100","author":"Taniguchi","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.radonc.2011.05.059_b0185","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ncb879","article-title":"Interaction of FANCD2 and NBS1 in the DNA damage response","volume":"4","author":"Nakanishi","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.radonc.2011.05.059_b0190","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1182\/blood-2003-11-3997","article-title":"Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin","volume":"105","author":"Montes de Oca","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.radonc.2011.05.059_b0195","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/sj.emboj.7601574","article-title":"Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability","volume":"26","author":"Bogliolo","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.radonc.2011.05.059_b0200","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.molcel.2008.12.003","article-title":"Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI","volume":"32","author":"Alpi","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.radonc.2011.05.059_b0205","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.radonc.2005.06.036","article-title":"The hypoxic proteome is influenced by gene-specific changes in mRNA translation","volume":"76","author":"Koritzinsky","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2011.05.059_b0210","doi-asserted-by":"crossref","first-page":"24204","DOI":"10.1074\/jbc.M109.006510","article-title":"Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response","volume":"284","author":"van den Beucken","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.radonc.2011.05.059_b0215","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.radonc.2011.05.059_b0220","doi-asserted-by":"crossref","unstructured":"Chan N, Pires IM, Bencokova Z, et al. Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Res 70:8045\u201354.","DOI":"10.1158\/0008-5472.CAN-10-2352"},{"key":"10.1016\/j.radonc.2011.05.059_b0225","doi-asserted-by":"crossref","first-page":"8504","DOI":"10.1128\/MCB.24.19.8504-8518.2004","article-title":"Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells","volume":"24","author":"Bindra","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.radonc.2011.05.059_b0230","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nsmb1252","article-title":"FANCI is a second monoubiquitinated member of the Fanconi anemia pathway","volume":"14","author":"Sims","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.radonc.2011.05.059_b0235","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.radonc.2011.05.059_b0240","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/BJ20081238","article-title":"Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha","volume":"416","author":"Pollard","year":"2008","journal-title":"Biochem J"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814011002684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814011002684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T23:27:24Z","timestamp":1588807644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814011002684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0167814011002684"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2011.05.059","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}