{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:24:33Z","timestamp":1790835873000,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":508,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.radonc.2012.02.002","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T10:07:30Z","timestamp":1329732450000},"page":"436-443","source":"Crossref","is-referenced-by-count":42,"title":["The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer"],"prefix":"10.1016","volume":"102","author":[{"given":"Maud H.W.","family":"Starmans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth C.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Haider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Seigneuric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Magagnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Koritzinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arek","family":"Kasprzyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Boutros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradly G.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lambin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2012.02.002_b0005","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nrc2501","article-title":"Hypoxia signalling through mTOR and the unfolded protein response in cancer","volume":"8","author":"Wouters","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2012.02.002_b0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrc2397","article-title":"Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response","volume":"8","author":"Dewhirst","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2012.02.002_b0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0093-7754(01)90211-8","article-title":"Biological consequences of tumor hypoxia","volume":"28","author":"Hockel","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0020","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrc1367","article-title":"Exploiting tumour hypoxia in cancer treatment","volume":"4","author":"Brown","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2012.02.002_b0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1172\/JCI40027","article-title":"The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5","volume":"120","author":"Rouschop","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.radonc.2012.02.002_b0030","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.radonc.2011.03.004","article-title":"Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck \u2013 a systematic review and meta-analysis","volume":"100","author":"Overgaard","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0035","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrc1976","article-title":"Linking oncogenic pathways with therapeutic opportunities","volume":"6","author":"Bild","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2012.02.002_b0040","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.radonc.2012.02.002_b0045","doi-asserted-by":"crossref","first-page":"13550","DOI":"10.1073\/pnas.0506230102","article-title":"An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival","volume":"102","author":"Miller","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.radonc.2012.02.002_b0050","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1371\/journal.pbio.0020007","article-title":"Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds","volume":"2","author":"Chang","year":"2004","journal-title":"PLoS Biol"},{"key":"10.1016\/j.radonc.2012.02.002_b0055","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1200\/JCO.2010.28.4273","article-title":"Genomic index of sensitivity to endocrine therapy for breast cancer","volume":"28","author":"Symmans","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0060","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1056\/NEJMra042342","article-title":"Microarray analysis and tumor classification","volume":"354","author":"Quackenbush","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2012.02.002_b0065","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1371\/journal.pmed.0030047","article-title":"Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers","volume":"3","author":"Chi","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.radonc.2012.02.002_b0070","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/sj.bjc.6604746","article-title":"Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types","volume":"99","author":"Starmans","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2012.02.002_b0075","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.radonc.2007.05.002","article-title":"Impact of supervised gene signatures of early hypoxia on patient survival","volume":"83","author":"Seigneuric","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1741-7015-7-9","article-title":"A compact VEGF signature associated with distant metastases and poor outcomes","volume":"7","author":"Hu","year":"2009","journal-title":"BMC Med"},{"key":"10.1016\/j.radonc.2012.02.002_b0085","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1158\/0008-5472.CAN-06-3322","article-title":"Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers","volume":"67","author":"Winter","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0090","doi-asserted-by":"crossref","first-page":"15215","DOI":"10.1074\/jbc.M511408200","article-title":"Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways","volume":"281","author":"Elvidge","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.radonc.2012.02.002_b0095","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3109\/02841861003614343","article-title":"Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro","volume":"49","author":"Sorensen","year":"2010","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0100","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/sj.bjc.6605450","article-title":"Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene","volume":"102","author":"Buffa","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2012.02.002_b0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.radonc.2012.02.002_b0110","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"Dai","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0120","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1158\/1078-0432.CCR-06-0357","article-title":"Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity","volume":"12","author":"Bachtiary","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2105-12-35","article-title":"VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R","volume":"12","author":"Chen","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.radonc.2012.02.002_b0130","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/gb-2003-4-4-r28","article-title":"GoMiner: a resource for biological interpretation of genomic and proteomic data","volume":"4","author":"Zeeberg","year":"2003","journal-title":"Genome Biol"},{"key":"10.1016\/j.radonc.2012.02.002_b0135","doi-asserted-by":"crossref","first-page":"W645","DOI":"10.1093\/nar\/gkl229","article-title":"Applications for protein sequence-function evolution data: mRNA\/protein expression analysis and coding SNP scoring tools","volume":"34","author":"Thomas","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0140","doi-asserted-by":"crossref","first-page":"R953","DOI":"10.1186\/bcr1325","article-title":"Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts","volume":"7","author":"Pawitan","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0145","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0140-6736(05)70933-8","article-title":"Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer","volume":"365","author":"Wang","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2012.02.002_b0150","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature04296","article-title":"Oncogenic pathway signatures in human cancers as a guide to targeted therapies","volume":"439","author":"Bild","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.radonc.2012.02.002_b0155","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ccr.2006.10.009","article-title":"Genomic and transcriptional aberrations linked to breast cancer pathophysiologies","volume":"10","author":"Chin","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.radonc.2012.02.002_b0160","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/jnci\/djj052","article-title":"Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis","volume":"98","author":"Sotiriou","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2012.02.002_b0165","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1158\/1078-0432.CCR-06-2765","article-title":"Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series","volume":"13","author":"Desmedt","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0170","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nature08021","article-title":"Genes that mediate breast cancer metastasis to the brain","volume":"459","author":"Bos","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.radonc.2012.02.002_b0175","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10549-008-0183-2","article-title":"The 76-gene signature defines high-risk patients that benefit from adjuvant tamoxifen therapy","volume":"116","author":"Zhang","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.radonc.2012.02.002_b0180","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10549-010-0897-9","article-title":"A gene expression signature identifies two prognostic subgroups of basal breast cancer","volume":"126","author":"Sabatier","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.radonc.2012.02.002_b0185","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10549-010-0856-5","article-title":"Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer","volume":"125","author":"Schmidt","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.radonc.2012.02.002_b0190","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1158\/0008-5472.CAN-06-0037","article-title":"The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis","volume":"66","author":"Barsyte-Lovejoy","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2012.02.002_b0195","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.radonc.2009.08.017","article-title":"Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3","volume":"92","author":"Mujcic","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0200","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.radonc.2011.05.059","article-title":"Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T","volume":"101","author":"Ramaekers","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0205","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.radonc.2009.06.029","article-title":"Autophagy is required during cycling hypoxia to lower production of reactive oxygen species","volume":"92","author":"Rouschop","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0210","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.radonc.2009.06.018","article-title":"Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment","volume":"92","author":"van den Beucken","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0215","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.radonc.2007.04.031","article-title":"Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia","volume":"83","author":"Koritzinsky","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0220","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.radonc.2007.04.028","article-title":"Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH","volume":"83","author":"Sorensen","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.02.002_b0225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.gde.2010.10.006","article-title":"Hypoxia and energetic tumour metabolism","volume":"21","author":"Brahimi-Horn","year":"2011","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.radonc.2012.02.002_b0230","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/156652410791317020","article-title":"Tumour reactions to hypoxia","volume":"10","author":"Voss","year":"2010","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.radonc.2012.02.002_b0235","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia-inducible factors and the response to hypoxic stress","volume":"40","author":"Majmundar","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.radonc.2012.02.002_b0240","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/wsbm.69","article-title":"Oxygen homeostasis","volume":"2","author":"Semenza","year":"2010","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"10.1016\/j.radonc.2012.02.002_b0245","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","article-title":"Defining the role of mTOR in cancer","volume":"12","author":"Guertin","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.radonc.2012.02.002_b0250","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/sj.emboj.7600998","article-title":"Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control","volume":"25","author":"Koritzinsky","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.radonc.2012.02.002_b0255","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1128\/MCB.22.21.7405-7416.2002","article-title":"Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha","volume":"22","author":"Koumenis","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.radonc.2012.02.002_b0260","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1186\/bcr2124","article-title":"Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures","volume":"10","author":"Wirapati","year":"2008","journal-title":"Breast Cancer Res"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781401200059X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781401200059X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T20:20:23Z","timestamp":1543177223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016781401200059X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S016781401200059X"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2012.02.002","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}