{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:12:21Z","timestamp":1779142341394,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.radonc.2012.03.012","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T20:22:45Z","timestamp":1334866965000},"page":"252-255","source":"Crossref","is-referenced-by-count":43,"title":["Increasing the risk of late rectal bleeding after high-dose radiotherapy for prostate cancer: The case of previous abdominal surgery. Results from a prospective trial"],"prefix":"10.1016","volume":"103","author":[{"given":"Riccardo","family":"Valdagni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Vavassori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Rancati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Fellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micaela","family":"Baccolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Cagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Gabriele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floranna","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loris","family":"Menegotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Filippo","family":"Monti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Stasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Fiorino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2012.03.012_b0005","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nrc2288","article-title":"Innovations in image-guided radiotherapy","volume":"7","author":"Verellen","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2012.03.012_b0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2009.08.004","article-title":"Dose\u2013volume effects for normal tissues in external radiotherapy: pelvis","volume":"93","author":"Fiorino","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0015","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ijrobp.2007.07.2354","article-title":"Clinical and dosimetric predictors of late rectal syndrome after 3DCRT for localized prostate cancer: preliminary results of a multicenter prospective study","volume":"70","author":"Fiorino","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.radonc.2009.09.004","article-title":"Clinical and dosimetric predictors of late rectal toxicity after conformal radiation for localized prostate cancer: results of a large multicenter observational study","volume":"93","author":"Fellin","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0025","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.ijrobp.2007.11.044","article-title":"Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer","volume":"70","author":"Zelefsky","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijrobp.2008.04.063","article-title":"Role of intensity-modulated radiotherapy in reducing toxicity in dose escalation for localized prostate cancer","volume":"73","author":"Al-Mamgani","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(02)00147-0","article-title":"Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer: analysis of a large group of patients pooled from three institutions","volume":"64","author":"Fiorino","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0040","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0360-3016(03)00665-5","article-title":"Rectal dose\u2013volume constraints in highdose conformal radiotherapy for localized prostate cancer","volume":"57","author":"Fiorino","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2004.08.013","article-title":"Fitting late rectal bleeding data using different NTCP models: results from an Italian multi-centric study [AIROPROS0101]","volume":"73","author":"Rancati","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0050","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.ijrobp.2006.10.040","article-title":"Predictors for rectal and intestinal acute toxicities during prostate cancer high-dose 3D-CRT: results of a prospective multicenter study","volume":"66","author":"Vavassori","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0055","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ijrobp.2007.11.037","article-title":"Development of a set of nomograms to predict acute lower gastrointestinal toxicity for prostate cancer 3D-CRT","volume":"71","author":"Valdagni","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0060","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.radonc.2011.06.032","article-title":"Inclusion of clinical risk factors into NTCP modelling of late rectal toxicity after high dose radiotherapy for prostate cancer","volume":"100","author":"Rancati","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0065","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.ijrobp.2011.03.028","article-title":"Is it time to tailor the prediction of radio-induced toxicity in prostate cancer patients? Building the first set of nomograms for late rectal syndrome","volume":"82","author":"Valdagni","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0070","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijrobp.2011.06.1953","article-title":"Late fecal incontinence after high-dose radiotherapy for prostate cancer: better prediction using longitudinal definitions","volume":"83","author":"Fiorino","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0075","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1088\/0031-9155\/57\/5\/1399","article-title":"Late rectal bleeding after 3D-CRT for prostate cancer: development of a neural-network-based predictive model","volume":"57","author":"Tomatis","year":"2012","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2012.03.012_b0080","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.ijrobp.2008.10.021","article-title":"To bleed or not to bleed. A prediction based on individual gene profiling combined with dose\u2013volume histogram shapes in prostate cancer patients undergoing Three-Dimensional Conformal Radiation Therapy","volume":"74","author":"Valdagni","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijrobp.2006.03.034","article-title":"Rectal bleeding, fecal incontinence and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling","volume":"66","author":"Peeters","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0090","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.ijrobp.2011.03.056","article-title":"The benefits of including clinical factors in rectal normal tissue complication probability modeling after radiotherapy for prostate cancer","volume":"82","author":"Defraene","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0095","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.ijrobp.2007.02.052","article-title":"A genetically determined dose\u2013volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapy","volume":"68","author":"Cesaretti","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0100","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1634\/theoncologist.7-2-136","article-title":"The effect of non-malignant systemic disease on tolerance to radiation therapy","volume":"7","author":"Chon","year":"2002","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2012.03.012_b0105","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0360-3016(01)01629-7","article-title":"Acute and late radiotherapy toxicity in patients with inflammatory bowel disease","volume":"51","author":"Song","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0110","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1200\/JCO.2006.07.9954","article-title":"Patient and treatment factors associated with complications after prostate brachytherapy","volume":"24","author":"Chen","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0115","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijrobp.2005.01.034","article-title":"Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors","volume":"62","author":"Okunieff","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2012.03.012_b0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1748-717X-5-16","article-title":"Cytokines levels, severity of acute mucositis and the need of PEG tube installation during chemo-radiation for head and neck cancer \u2013 a prospective pilot study","volume":"5","author":"Meirovits","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1748-717X-5-22","article-title":"Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis","volume":"5","author":"Ong","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2012.03.012_b0130","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1158\/1078-0432.CCR-09-0245","article-title":"Longitudinal cytokine expression during IMRT for prostate cancer and acute treatment toxicity","volume":"15","author":"Christensen","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2012.03.012_b0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/157340307779939925","article-title":"Cardiac surgery and inflammation: the inflammatory response and strategies to reduce the systemic inflammatory response syndrome","volume":"3","author":"Hunt","year":"2007","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.radonc.2012.03.012_b0140","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri1806","article-title":"Cells, tumour immunity and immunotherapy","volume":"6","author":"Zou","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.radonc.2012.03.012_b0145","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114509377867","article-title":"Inflammatory disease processes and interactions with nutrition","volume":"101","author":"Calder","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.radonc.2012.03.012_b0150","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/01.SLA.0000055742.79045.7E","article-title":"Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy","volume":"237","author":"Kalff","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2012.03.012_b0155","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.mehy.2008.06.008","article-title":"Why appendectomies may lead to an increased risk of functional gastrointestinal disorders?","volume":"71","author":"Sleator","year":"2008","journal-title":"Med Hypotheses"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814012001466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814012001466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T11:46:58Z","timestamp":1561636018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814012001466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0167814012001466"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2012.03.012","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}