{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:09:20Z","timestamp":1790442560056,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.radonc.2013.03.002","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T14:16:43Z","timestamp":1364393803000},"page":"333-340","source":"Crossref","is-referenced-by-count":71,"title":["A dose escalation study with intensity modulated radiation therapy (IMRT) in T2N0, T2N1, T3N0 squamous cell carcinomas (SCC) of the oropharynx, larynx and hypopharynx using a simultaneous integrated boost (SIB) approach"],"prefix":"10.1016","volume":"106","author":[{"given":"Mathieu","family":"Leclerc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Maingon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hamoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Dalban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Calais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Nuyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Serre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Gr\u00e9goire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2013.03.002_b0005","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijrobp.2011.07.014","article-title":"Distant metastases in head-and-neck squamous cell carcinoma treated with intensity-modulated radiotherapy","volume":"83","author":"Yao","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.002_b0010","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/hed.10275","volume":"25","author":"Al-Othman","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2013.03.002_b0015","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(06)69121-6","article-title":"Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis","volume":"368","author":"Bourhis","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2013.03.002_b0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0360-3016(00)00663-5","article-title":"A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003","volume":"48","author":"Fu","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.002_b0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0167-8140(92)90242-M","article-title":"Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy","volume":"25","author":"Horiot","year":"1992","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0167-8140(97)00079-0","article-title":"Accelerated fractionation compared to conventional fractionation improves locoregional control in the radiotherapy of advanced head and neck cancer: results of the EORTC 22581 randomized trial","volume":"44","author":"Horiot","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0035","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(03)14361-9","article-title":"Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial","volume":"362","author":"Overgaard","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2013.03.002_b0040","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1200\/JCO.2006.08.057","article-title":"Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial","volume":"24","author":"Bourhis","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0360-3016(99)00101-7","article-title":"Smart (simultaneous modulated accelerated radiation therapy) boost: a new accelerated fractionation schedule for the treatment of head and neck cancer with intensity modulated radiotherapy","volume":"45","author":"Butler","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.002_b0050","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0360-3016(99)00438-1","article-title":"Radiobiological considerations in the design of fractionation strategies fir intensity-modulated radiation therapy of head and neck cancers","volume":"46","author":"Mohan","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.002_b0055","unstructured":"National Cancer Institute. Common toxicity criteria (CTC) v2.0. Available from: http:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm. Accessed August 2012."},{"key":"10.1016\/j.radonc.2013.03.002_b0060","unstructured":"RTOG. RTOG\/EORTC late radiation morbidity scoring schema. Available from: http:\/\/www.rtog.org\/ResearchAssociates\/AdverseEventReporting\/RTOGEORTCLateRadiationMorbidityScoringSchema.aspx. Accessed August 2012."},{"key":"10.1016\/j.radonc.2013.03.002_b0065","unstructured":"National Cancer Institute. Common terminology criteria for adverse events (CTCAE) v4.0. Available from: http:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm. Accessed August 2012."},{"key":"10.1016\/j.radonc.2013.03.002_b0070","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1278-3218(03)00016-7","article-title":"Quality assurance program for intensity-modulated radiotherapy (IMRT) treatments of head and neck carcinomas","volume":"7","author":"Marci\u00e9","year":"2003","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.radonc.2013.03.002_b0075","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(00)00202-4","article-title":"Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience","volume":"56","author":"Gregoire","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2006.03.009","article-title":"Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck","volume":"79","author":"Gregoire","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0085","unstructured":"Prescribing, recording and reporting photon beam therapy. International Commission on Radiation Units and Measurements, report 50, 1993."},{"key":"10.1016\/j.radonc.2013.03.002_b0090","unstructured":"Prescribing, recording and reporting photon beam therapy (supplement to ICRU report 50). International Commission on Radiation Units and Measurements, report 62, 1999."},{"key":"10.1016\/j.radonc.2013.03.002_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(89)90015-9","article-title":"Optimal two-stage designs for phase II clinical trials","volume":"10","author":"Simon","year":"1989","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.radonc.2013.03.002_b0100","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC collaborative group. meta-analysis of chemotherapy on head and neck cancer","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2013.03.002_b0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"MACH-NC collaborative group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0110","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.radonc.2011.05.036","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site: MACH-CH collaborative group","volume":"100","author":"Blanchard","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0115","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1470-2045(11)70346-1","article-title":"Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99\u201302): an open-label phase 3 randomised trial","volume":"13","author":"Bourhis","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0167-8140(91)90106-Q","article-title":"Hypofractionation: lessons from complications","volume":"20","author":"Fletcher","year":"1991","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.radonc.2012.01.002","article-title":"Prevalence and peak incidence of acute and late normal tissue morbidity in the DAHANCA 6&7 randomised trial with accelerated radiotherapy for head and neck cancer","volume":"103","author":"Mortensen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0130","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radioherapy with or without chemotherapy: a systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0135","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1200\/JCO.1998.16.4.1318","article-title":"Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study","volume":"16","author":"Wendt","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0140","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ijrobp.2004.03.010","article-title":"Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II\u2014clinical results","volume":"60","author":"Lauve","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.002_b0145","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","article-title":"Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis","volume":"26","author":"Machtay","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0360-3016(02)03819-1","article-title":"Late toxicity results of the GORTEC 94\u201301 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT\/SOMA, RTOG\/EORTC, and NCI-CTC scoring systems","volume":"55","author":"Denis","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.002_b0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.radonc.2012.05.004","article-title":"Predictors of severe late radiotherapy related toxicity after hyperfractionated radiotherapy with or without concomitant cisplatin in locally advanced head and neck cancer. Secondary retrospective analysis of a randomized phase III trial (SAKK 10\/94)","volume":"104","author":"Ghadjar","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0160","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.ijrobp.2009.04.011","article-title":"Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00\u201322)","volume":"76","author":"Eisbruch","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.002_b0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.radonc.2011.02.010","article-title":"The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: evaluation of the randomised DAHANCA 6&7 trial","volume":"100","author":"Lassen","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.002_b0170","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.radonc.2011.06.020","article-title":"Maximum tolerated dose in a phase I trial on adaptive dose painting by numbers for head and neck cancer","volume":"101","author":"Madani","year":"2011","journal-title":"Radiother Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013000819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013000819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T13:55:34Z","timestamp":1539784534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814013000819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0167814013000819"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2013.03.002","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}