{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:28:38Z","timestamp":1788870518875,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["C8996\/A3803"],"award-info":[{"award-number":["C8996\/A3803"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ICR-CTSU","award":["C1491\/A9895"],"award-info":[{"award-number":["C1491\/A9895"]}]},{"name":"National Cancer Research Network"},{"name":"Cancer Research UK, Section of Radiotherapy","award":["C46\/A2131"],"award-info":[{"award-number":["C46\/A2131"]}]},{"name":"Head and Neck Program","award":["C7224\/A13407"],"award-info":[{"award-number":["C7224\/A13407"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.radonc.2013.03.006","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T20:15:39Z","timestamp":1364328939000},"page":"346-351","source":"Crossref","is-referenced-by-count":23,"title":["The effect of concomitant chemotherapy on parotid gland function following head and neck IMRT"],"prefix":"10.1016","volume":"106","author":[{"given":"Aisha B.","family":"Miah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Gulliford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreerang A.","family":"Bhide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane H.","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate L.","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Nutting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2013.03.006_b0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2013.03.006_b0010","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.radonc.2011.05.010","article-title":"Development of NTCP models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva: the role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0015","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2013.03.006_b0020","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0360-3016(00)01441-3","article-title":"A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results","volume":"49","author":"Chao","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0025","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2013.03.006_b0030","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0035","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1754-4505.1998.tb00913.x","article-title":"The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers","volume":"18","author":"D\u2019Hondt","year":"1998","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.radonc.2013.03.006_b0040","unstructured":"Cancer Therapy Evaluation Program. Common terminology criteria for adverse events v3.0 2003."},{"key":"10.1016\/j.radonc.2013.03.006_b0045","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","article-title":"Radiotherapy dose\u2013volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0050","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0055","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.ijrobp.2006.11.012","article-title":"Impact of intensity-modulated radiotherapy on health-related quality of life for head and neck cancer patients: matched-pair comparison with conventional radiotherapy","volume":"67","author":"Graff","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0060","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.clon.2007.07.001","article-title":"Target volume definition for head and neck intensity modulated radiotherapy: pre-clinical evaluation of PARSPORT trial guidelines","volume":"19","author":"Guerrero Urbano","year":"2007","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.radonc.2013.03.006_b0065","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.ijrobp.2008.12.071","article-title":"Effect of Cisplatin on parotid gland function in concomitant radiochemotherapy","volume":"75","author":"Hey","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0070","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0360-3016(94)00471-4","article-title":"Analysis of clinical complication data for radiation hepatitis using a parallel architecture model","volume":"31","author":"Jackson","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0075","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.oraloncology.2007.01.015","article-title":"Adjuvant chemotherapy in breast cancer patients induces temporary salivary gland hypofunction","volume":"44","author":"Jensen","year":"2008","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0080","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1200\/JCO.2007.11.5501","article-title":"Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients","volume":"25","author":"Kam","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0085","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0360-3016(99)00166-2","article-title":"Assessment of salivary gland dysfunction following chemoradiotherapy using quantitative salivary gland scintigraphy","volume":"45","author":"Kosuda","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0090","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/02841860310004364","article-title":"Cisplatin and radiotherapy in the treatment of locally advanced head and neck cancer \u2013 a review of their cooperation","volume":"42","author":"Marcu","year":"2003","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0095","doi-asserted-by":"crossref","first-page":"c4690","DOI":"10.1136\/bmj.c4690","article-title":"Head and neck cancer \u2013 Part 2: treatment and prognostic factors","volume":"341","author":"Mehanna","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.radonc.2013.03.006_b0100","doi-asserted-by":"crossref","first-page":"S211","DOI":"10.1016\/S0167-8140(11)70641-7","article-title":"Recovery of salivary gland toxicity: contralateral parotid gland versus bilateral parotid sparing IMRT (PARSPORT versus PARSPORT II)","volume":"99","author":"Miah","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0110","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2013.03.006_b0115","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ijrobp.2006.06.013","article-title":"Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial","volume":"66","author":"Pow","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"A","key":"10.1016\/j.radonc.2013.03.006_b0125","first-page":"563","article-title":"Does chemotherapy worsen intensity modulated radiotherapy induced parotid gland toxicity?","volume":"91","author":"Richards","year":"2012","journal-title":"J Dent Res"},{"key":"10.1016\/j.radonc.2013.03.006_b0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0167-8140(95)97447-L","article-title":"EORTC Late Effects Working Group. Overview of late effects normal tissues (LENT) scoring system","volume":"35","author":"Rubin","year":"1995","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.03.006_b0135","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0360-3016(95)00057-6","article-title":"RTOG Late Effects Working Group. Overview late effects of normal tissues (LENT) scoring system","volume":"31","author":"Rubin","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.03.006_b0140","doi-asserted-by":"crossref","first-page":"M310","DOI":"10.1093\/gerona\/52A.5.M310","article-title":"The relationship between dehydration and parotid salivary gland function in young and older healthy adults","volume":"52","author":"Ship","year":"1997","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.radonc.2013.03.006_b0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-8140(83)80021-8","article-title":"A new isoeffect curve for change in dose per fraction","volume":"1","author":"Withers","year":"1983","journal-title":"Radiother Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013000856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013000856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T14:27:14Z","timestamp":1539786434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814013000856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0167814013000856"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2013.03.006","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}