{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:05:18Z","timestamp":1791641118830,"version":"4.3.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"Maastro Cancer Foundation","award":["KWF UM2012-5394"],"award-info":[{"award-number":["KWF UM2012-5394"]}]},{"name":"EU 7th framework","award":["2008-222741"],"award-info":[{"award-number":["2008-222741"]}]}],"content-domain":{"domain":["thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.radonc.2013.06.018","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T09:15:27Z","timestamp":1373361327000},"page":"523-528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs"],"prefix":"10.1016","volume":"108","author":[{"given":"Ludwig","family":"Dubois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah G.J.A.","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.A.","family":"van Kuijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Yaromina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja G.","family":"Lieuwes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Saraya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Biemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marouan","family":"Rami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda Kumar","family":"Parvathaneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vooijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Winum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lambin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2013.06.018_b0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.bjc.6600936","article-title":"Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer","volume":"89","author":"Potter","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2013.06.018_b0010","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18632\/oncotarget.422","article-title":"Recent developments in targeting carbonic anhydrase IX for cancer therapeutics","volume":"3","author":"McDonald","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.radonc.2013.06.018_b0015","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","article-title":"Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.radonc.2013.06.018_b0020","doi-asserted-by":"crossref","first-page":"20299","DOI":"10.1074\/jbc.M109.006478","article-title":"The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths","volume":"284","author":"Swietach","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.radonc.2013.06.018_b0025","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","article-title":"Interfering with pH regulation in tumours as a therapeutic strategy","volume":"10","author":"Neri","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.radonc.2013.06.018_b0030","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2007.04.018","article-title":"Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors","volume":"83","author":"Dubois","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0035","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.radonc.2009.06.019","article-title":"Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model","volume":"92","author":"Dubois","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0040","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.radonc.2011.05.045","article-title":"Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation","volume":"99","author":"Dubois","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0045","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.bmcl.2009.06.022","article-title":"In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives","volume":"19","author":"Ahlskog","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.radonc.2013.06.018_b0050","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1021\/cb1003477","article-title":"Selection of carbonic anhydrase IX inhibitors from one million DNA-encoded compounds","volume":"6","author":"Buller","year":"2011","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.radonc.2013.06.018_b0055","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-10-4261","article-title":"Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors","volume":"71","author":"Lou","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2013.06.018_b0060","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1021\/jm300529u","article-title":"Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts","volume":"55","author":"Gieling","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.radonc.2013.06.018_b0065","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/14756366.2012.736979","article-title":"Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cells in vitro","volume":"28","author":"Gieling","year":"2013","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.radonc.2013.06.018_b0070","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/bjc.1982.300","article-title":"A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo","volume":"46","author":"Overgaard","year":"1982","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2013.06.018_b0075","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(97)00220-X","article-title":"A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish head and neck cancer study (DAHANCA) protocol 5\u201385","volume":"46","author":"Overgaard","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.radonc.2009.06.018","article-title":"Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment","volume":"92","author":"van den Beucken","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2005.06.038","article-title":"Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study","volume":"77","author":"Nordsmark","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0090","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.radonc.2010.04.020","article-title":"Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation","volume":"96","author":"Yaromina","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0095","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.radonc.2009.11.007","article-title":"Glycolytic metabolism and tumour response to fractionated irradiation","volume":"94","author":"Sattler","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.018_b0100","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1158\/1078-0432.CCR-11-1877","article-title":"Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy","volume":"18","author":"McIntyre","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2013.06.018_b0105","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1269\/jrr.46.453","article-title":"Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo","volume":"46","author":"Sugie","year":"2005","journal-title":"J Radiat Res"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013002971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013002971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T14:24:33Z","timestamp":1539527073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814013002971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0167814013002971"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2013.06.018","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2013.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}