{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:36:19Z","timestamp":1792532179140,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.radonc.2013.06.042","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T10:00:18Z","timestamp":1376388018000},"page":"416-421","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Fatigue during chemoradiotherapy for nasopharyngeal cancer and its relationship to radiation dose distribution in the brain"],"prefix":"10.1016","volume":"110","author":[{"given":"Ceri","family":"Powell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Morden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Gulliford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha B.","family":"Miah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreerang","family":"Bhide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.","family":"Nutting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2013.06.042_b0005","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijrobp.2003.10.008","article-title":"Fatigue during breast radiotherapy and its relationship to biological factors","volume":"59","author":"Wratten","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.06.042_b0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ijrobp.2007.01.024","article-title":"Fatigue during head-and-neck radiotherapy: prospective study on 117 consecutive patients","volume":"68","author":"Jereczek-Fossa","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.06.042_b0015","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/bjc.1998.599","article-title":"Fatigue and radiotherapy: (A) experience in patients undergoing treatment","volume":"78","author":"Smets","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2013.06.042_b0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.radonc.2011.06.028","article-title":"Somnolence syndrome in patients receiving radical radiotherapy for primary brain tumours: a prospective study","volume":"100","author":"Powell","year":"2011","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.radonc.2013.06.042_b0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.radonc.2012.07.008","article-title":"Skull base meningiomas: long-term results and patient self-reported outcome in 507 patients treated with fractionated stereotactic radiotherapy (FSRT) or intensity modulated radiotherapy (IMRT)","volume":"106","author":"Combs","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.042_b0030","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1634\/theoncologist.5-5-353","article-title":"Impact of cancer-related fatigue on the lives of patients: new findings from the fatigue coalition","volume":"5","author":"Curt","year":"2000","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2013.06.042_b0035","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/annonc\/mdm057","article-title":"Impact of fatigue on overall quality of life in lung and breast cancer patients selected for high-dose radiotherapy","volume":"18","author":"Dagnelie","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2013.06.042_b0040","first-page":"3139","article-title":"Prospective evaluation of the prevalence and severity of fatigue in patients with prostate cancer undergoing radical external beam radiotherapy and neoadjuvant hormone therapy","volume":"13","author":"Truong","year":"2006","journal-title":"Can J Urol"},{"key":"10.1016\/j.radonc.2013.06.042_b0045","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1053\/j.seminoncol.2004.09.002","article-title":"Concomitant radiochemotherapy or accelerated radiotherapy: analysis of two randomized trials of the French Head and Neck Cancer Group (GORTEC)","volume":"31","author":"Bourhis","year":"2004","journal-title":"Semin Oncol"},{"key":"10.1016\/j.radonc.2013.06.042_b0050","first-page":"4","article-title":"Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. The fatigue coalition","volume":"34","author":"Vogelzang","year":"1997","journal-title":"Semin Hematol"},{"key":"10.1016\/j.radonc.2013.06.042_b0055","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/cncr.21364","article-title":"Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5weeks of radiotherapy for cancer","volume":"104","author":"Hickok","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2013.06.042_b0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1634\/theoncologist.12-2-221","article-title":"Fatigue experiences in hepatocellular carcinoma patients during six weeks of stereotactic radiotherapy","volume":"12","author":"Lai","year":"2007","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2013.06.042_b0065","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00002820-197912000-00005","article-title":"Fatigue in patients receiving localized radiation","volume":"2","author":"Haylock","year":"1979","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.radonc.2013.06.042_b0070","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00520-007-0229-8","article-title":"Prospective evaluation of fatigue during a course of curative radiotherapy for localised prostate cancer","volume":"15","author":"Danjoux","year":"2007","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2013.06.042_b0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00002820-199804000-00006","article-title":"Fatigue in women with breast cancer receiving radiation therapy","volume":"21","author":"Irvine","year":"1998","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.radonc.2013.06.042_b0080","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/(SICI)1520-6823(1999)7:3<178::AID-ROI7>3.0.CO;2-0","article-title":"Prospective study of fatigue in localized prostate cancer patients undergoing radiotherapy","volume":"7","author":"Monga","year":"1999","journal-title":"Radiat Oncol Investig"},{"key":"10.1016\/j.radonc.2013.06.042_b0085","first-page":"463","article-title":"Prevalence of fatigue among cancer patients undergoing external radiotherapy","volume":"35","author":"Biswal","year":"2004","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.radonc.2013.06.042_b0090","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1634\/theoncologist.2011-0437","article-title":"Time course and predictors for cancer-related fatigue in a series of oropharyngeal cancer patients treated with chemoradiation therapy","volume":"17","author":"Spratt","year":"2012","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2013.06.042_b0095","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0885-3924(96)00008-5","article-title":"Frequency and correlates of fatigue in lung cancer patients receiving radiation therapy: implications for management","volume":"11","author":"Hickok","year":"1996","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.radonc.2013.06.042_b0100","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0885-3924(93)90127-H","article-title":"Treatment-related fatigue and serum interleukin-1 levels in patients during external beam irradiation for prostate cancer","volume":"8","author":"Greenberg","year":"1993","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.radonc.2013.06.042_b0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2013.06.042_b0110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.radonc.2012.07.005","article-title":"Dosimetric explanations of fatigue in head and neck radiotherapy: an analysis from the PARSPORT Phase III trial","volume":"104","author":"Gulliford","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.042_b0115","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3322\/canjclin.55.4.242","article-title":"TNM staging of cancers of the head and neck: striving for uniformity among diversity","volume":"55","author":"Patel","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2013.06.042_b0120","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0360-3016(01)01488-2","article-title":"Impact of hemoglobin level and use of recombinant erythropoietin on efficacy of preoperative chemoradiation therapy for squamous cell carcinoma of the oral cavity and oropharynx","volume":"50","author":"Glaser","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.06.042_b0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.radonc.2005.06.039","article-title":"Assessment of a customised immobilisation system for head and neck IMRT using electronic portal imaging","volume":"77","author":"Humphreys","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.042_b0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-8140(00)00202-4","article-title":"Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience","volume":"56","author":"Gregoire","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2013.06.042_b0135","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.canrad.2011.04.003","article-title":"State of the art on dose prescription, reporting and recording in intensity-modulated radiation therapy (ICRU report No. 83)","volume":"15","author":"Gregoire","year":"2011","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.radonc.2013.06.042_b0140","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1210\/jc.2005-1525","article-title":"Hypothalamic\u2013pituitary dysfunction after irradiation of nonpituitary brain tumors in adults","volume":"90","author":"Agha","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.radonc.2013.06.042_b0145","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbi.2011.09.006","article-title":"The biobehavioral and neuroimmune impact of low-dose ionizing radiation","volume":"26","author":"York","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.radonc.2013.06.042_b0150","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1158\/1078-0432.CCR-08-2584","article-title":"Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer","volume":"15","author":"Bower","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2013.06.042_b0155","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(00)02088-9","article-title":"Cytokine-induced sickness behaviour: mechanisms and implications","volume":"25","author":"Konsman","year":"2002","journal-title":"Trends Neurosci"},{"issue":"1","key":"10.1016\/j.radonc.2013.06.042_b0160","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00520-012-1508-6","article-title":"Psychological and immunological characteristics of fatigued women undergoing radiotherapy for early-stage breast cancer","volume":"21","author":"Courtier","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2013.06.042_b0165","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.pmr.2008.12.007","article-title":"Functional neuroimaging of fatigue","volume":"20","author":"DeLuca","year":"2009","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"10.1016\/j.radonc.2013.06.042_b0170","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1212\/WNL.48.6.1566","article-title":"Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study","volume":"48","author":"Roelcke","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.radonc.2013.06.042_b0175","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000119307","article-title":"Comparison of 99m Tc HMPAO SPECT scan between chronic fatigue syndrome, major depression and healthy controls: an exploratory study of clinical correlates of regional cerebral blood flow","volume":"34","author":"Fischler","year":"1996","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.radonc.2013.06.042_b0180","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1468-1331.2008.02090.x","article-title":"Mental fatigue alters the pattern and increases the volume of cerebral activation required for a motor task in multiple sclerosis patients with fatigue","volume":"15","author":"Tartaglia","year":"2008","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.radonc.2013.06.042_b0185","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/01.PSY.0000038942.33335.9B","article-title":"Single-photon emission computerized tomography and neurocognitive function in patients with chronic fatigue syndrome","volume":"65","author":"Schmaling","year":"2003","journal-title":"Psychosom Med"},{"key":"10.1016\/j.radonc.2013.06.042_b0190","doi-asserted-by":"crossref","first-page":"54S","DOI":"10.1016\/S0002-9343(98)00179-X","article-title":"Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data","volume":"105","author":"Tirelli","year":"1998","journal-title":"Am J Med"},{"key":"10.1016\/j.radonc.2013.06.042_b0195","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.neuroimage.2005.02.011","article-title":"Objective evidence of cognitive complaints in chronic fatigue syndrome: a BOLD fMRI study of verbal working memory","volume":"26","author":"Lange","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.radonc.2013.06.042_b0200","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0140-6736(04)15794-2","article-title":"Fatigue in neurological disorders","volume":"363","author":"Chaudhuri","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2013.06.042_b0205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0022-510X(00)00411-1","article-title":"Fatigue and basal ganglia","volume":"179","author":"Chaudhuri","year":"2000","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.radonc.2013.06.042_b0210","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1006\/nimg.2001.1011","article-title":"Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis","volume":"15","author":"Filippi","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.radonc.2013.06.042_b0215","first-page":"45","article-title":"Radiation injury of the brain","volume":"12","author":"Valk","year":"1991","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.radonc.2013.06.042_b0220","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/0360-3016(80)90175-3","article-title":"Therapeutic irradiation and brain injury","volume":"6","author":"Sheline","year":"1980","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.06.042_b0225","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0360-3016(98)90011-6","article-title":"Adverse effects of brain irradiation correlated with MR and CT imaging","volume":"15","author":"Constine","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.06.042_b0230","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.ijrobp.2007.08.020","article-title":"Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging study","volume":"70","author":"Nagesh","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2013.06.042_b0235","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1118\/1.4745560","article-title":"Radiation therapy effects on white matter fiber tracts of the limbic circuit","volume":"39","author":"Nazem-Zadeh","year":"2012","journal-title":"Med Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013003241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814013003241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T20:55:42Z","timestamp":1539464142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814013003241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0167814013003241"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2013.06.042","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatigue during chemoradiotherapy for nasopharyngeal cancer and its relationship to radiation dose distribution in the brain","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2013.06.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}