{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:53:42Z","timestamp":1784177622383,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T00:00:00Z","timestamp":1412812800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.radonc.2014.09.013","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T20:45:38Z","timestamp":1413492338000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"title":["Development of a multivariable normal tissue complication probability (NTCP) model for tube feeding dependence after curative radiotherapy\/chemo-radiotherapy in head and neck cancer"],"prefix":"10.1016","volume":"113","author":[{"given":"Kim","family":"Wopken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik P.","family":"Bijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen","family":"van der Schaaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Paul","family":"van der Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Chouvalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel J.H.M.","family":"Steenbakkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Doornaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J.","family":"Slotman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoukje F.","family":"Oosting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda E.M.C.","family":"Christianen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard F.A.M.","family":"van der Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.N.","family":"Roodenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ren\u00e9 Leemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma M.","family":"Verdonck-de Leeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Langendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2014.09.013_b0005","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijrobp.2008.11.041","article-title":"Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose\u2013effect relationships for the swallowing structures","volume":"75","author":"Dirix","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00455-011-9326-4","article-title":"Objective assessment of swallowing function after definitive concurrent (chemo)radiotherapy in patients with head and neck cancer","volume":"26","author":"Agarwal","year":"2011","journal-title":"Dysphagia"},{"key":"10.1016\/j.radonc.2014.09.013_b0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/0973-1482.63563","article-title":"Prospective subjective evaluation of swallowing function and dietary pattern in head and neck cancers treated with concomitant chemo-radiation","volume":"6","author":"Agarwal","year":"2010","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.radonc.2014.09.013_b0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0360-3016(02)02712-8","article-title":"Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer","volume":"53","author":"Eisbruch","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/annonc\/mdh101","article-title":"Dysphagia following chemoradiation for locally advanced head and neck cancer","volume":"15","author":"Nguyen","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0030","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0360-3016(01)01544-9","article-title":"Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy \u2013 results of a multicentric randomized German trial in advanced head-and-neck cancer","volume":"50","author":"Staar","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijrobp.2009.10.057","article-title":"Weekly dose\u2013volume parameters of mucosa and constrictor muscles predict the use of percutaneous endoscopic gastrostomy during exclusive intensity-modulated radiotherapy for oropharyngeal cancer","volume":"79","author":"Sanguineti","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ijrobp.2009.02.017","article-title":"Dosimetric factors associated with long-term dysphagia after definitive radiotherapy for squamous cell carcinoma of the head and neck","volume":"76","author":"Caudell","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0045","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ijrobp.2008.09.053","article-title":"Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer","volume":"74","author":"Citrin","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0050","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1200\/JCO.2005.12.060","article-title":"Concomitant boost radiation plus concurrent cisplatin for advanced head and neck carcinomas: radiation therapy oncology group phase II trial 99-14","volume":"23","author":"Ang","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archoto.2007.43","article-title":"Changes in quality of life over 1year in patients with head and neck cancer","volume":"134","author":"Ronis","year":"2008","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.radonc.2014.09.013_b0060","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ijrobp.2004.05.050","article-title":"Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT?","volume":"60","author":"Eisbruch","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0065","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.ijrobp.2007.02.049","article-title":"Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose\u2013effect relationships for the swallowing structures","volume":"68","author":"Feng","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0070","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1200\/JCO.2009.24.6199","article-title":"Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results","volume":"28","author":"Feng","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0075","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/j.ijrobp.2010.12.067","article-title":"Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates","volume":"81","author":"Eisbruch","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0080","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.radonc.2011.11.001","article-title":"The potential benefit of swallowing sparing intensity modulated radiotherapy to reduce swallowing dysfunction: an in silico planning comparative study","volume":"103","author":"van der Laan","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0085","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.radonc.2013.05.004","article-title":"Swallowing-sparing intensity-modulated radiotherapy for head and neck cancer patients: treatment planning optimization and clinical introduction","volume":"107","author":"van der Laan","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0090","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1002\/lary.23597","article-title":"Sparing the larynx and esophageal inlet expedites feeding tube removal in patients with stage III\u2013IV oropharyngeal squamous cell carcinoma treated with intensity-modulated radiotherapy","volume":"122","author":"Amin","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.radonc.2014.09.013_b0095","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.radonc.2011.05.010","article-title":"Development of NTCP models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva: The role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.radonc.2011.08.009","article-title":"Predictive modelling for swallowing dysfunction after primary (chemo)radiation: Results of a prospective observational study","volume":"105","author":"Christianen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0105","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.radonc.2011.05.015","article-title":"Delineation of organs at risk involved in swallowing for radiotherapy treatment planning","volume":"101","author":"Christianen","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0110","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.radonc.2009.09.008","article-title":"Delineation guidelines for organs at risk involved in radiation-induced salivary dysfunction and xerostomia","volume":"93","author":"van de Water","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.radonc.2003.09.011","article-title":"CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines","volume":"69","author":"Gregoire","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2006.03.009","article-title":"Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck","volume":"79","author":"Gregoire","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0125","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the Lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J R Statist Soc B"},{"key":"10.1016\/j.radonc.2014.09.013_b0130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1467-9868.2005.00532.x","article-title":"Model selection and estimation in regression with grouped variables","volume":"68","author":"Yuan","year":"2006","journal-title":"J R Statist Soc B"},{"key":"10.1016\/j.radonc.2014.09.013_b0135","doi-asserted-by":"crossref","first-page":"e677","DOI":"10.1016\/j.ijrobp.2011.09.036","article-title":"Impact of statistical learning methods on the predictive power of multivariate normal tissue complication probability models","volume":"82","author":"Xu","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/EDE.0b013e3181c30fb2","article-title":"Assessing the performance of prediction models: a framework for traditional and novel measures","volume":"21","author":"Steyerberg","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.radonc.2014.09.013_b0145","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/aje\/kwq223","article-title":"External validity of risk models: use of benchmark values to disentangle a case-mix effect from incorrect coefficients","volume":"172","author":"Vergouwe","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.radonc.2014.09.013_b0150","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.ijrobp.2008.02.048","article-title":"Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy","volume":"72","author":"Caglar","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0155","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2007.07.009","article-title":"Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose\u2013effect relationship","volume":"85","author":"Levendag","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.radonc.2007.06.004","article-title":"Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters","volume":"85","author":"Jensen","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0165","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.radonc.2013.12.007","article-title":"Dose to the inferior pharyngeal constrictor predicts prolonged gastrostomy tube dependence with concurrent intensity-modulated radiation therapy and chemotherapy for locally-advanced head and neck cancer","volume":"110","author":"Vlacich","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0170","first-page":"253","article-title":"Rhythms in salivary flow rate and composition","volume":"2","author":"Dawes","year":"1974","journal-title":"Int J Chronobiol"},{"key":"10.1016\/j.radonc.2014.09.013_b0175","doi-asserted-by":"crossref","unstructured":"van Rij CM, Oughlane-Heemsbergen WD, Ackerstaff AH, Lamers EA, Balm AJ, Rasch CR. Parotid gland sparing IMRT for head and neck cancer improves xerostomia related quality of life. Radiat Oncol 2008;3:41\u2013717X-3-41.","DOI":"10.1186\/1748-717X-3-41"},{"key":"10.1016\/j.radonc.2014.09.013_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijrobp.2008.07.059","article-title":"Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program","volume":"74","author":"Vergeer","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.09.013_b0185","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hed.1037","article-title":"Effects of xerostomia on perception and performance of swallow function","volume":"23","author":"Logemann","year":"2001","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2014.09.013_b9015","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00066-012-0257-2","article-title":"Xerostomia after radiotherapy. What matters \u2013 mean total dose or dose to each parotid gland?","volume":"189","author":"Tribius","year":"2013","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2014.09.013_b0190","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.radonc.2007.03.002","article-title":"Unilateral versus bilateral irradiation in squamous cell head and neck cancer in relation to patient-rated xerostomia and sticky saliva","volume":"85","author":"Jellema","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.09.013_b0195","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(03)14361-9","article-title":"Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial","volume":"362","author":"Overgaard","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2014.09.013_b0200","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","article-title":"Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck","volume":"354","author":"Bonner","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2014.09.013_b0205","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3748\/wjg.v17.i8.1004","article-title":"Prophylactic PEG placement in head and neck cancer: how many feeding tubes are unused (and unnecessary)?","volume":"17","author":"Madhoun","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.radonc.2014.09.013_b0210","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00455-011-9360-2","article-title":"Does PEG use cause dysphagia in head and neck cancer patients?","volume":"27","author":"Langmore","year":"2012","journal-title":"Dysphagia"},{"key":"10.1016\/j.radonc.2014.09.013_b0215","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/1097-0142(20010501)91:9<1785::AID-CNCR1197>3.0.CO;2-1","article-title":"Enteral nutrition during the treatment of head and neck carcinoma: is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube?","volume":"91","author":"Mekhail","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2014.09.013_b0220","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.oraloncology.2011.11.022","article-title":"Enteral feeding outcomes after chemoradiotherapy for oropharynx cancer: a role for a prophylactic gastrostomy?","volume":"48","author":"Williams","year":"2012","journal-title":"Oral Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814014004009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814014004009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:43:11Z","timestamp":1717461791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814014004009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0167814014004009"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2014.09.013","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a multivariable normal tissue complication probability (NTCP) model for tube feeding dependence after curative radiotherapy\/chemo-radiotherapy in head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2014.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}