{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:04:21Z","timestamp":1793131461567,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":413,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["RUG-2007-3890"],"award-info":[{"award-number":["RUG-2007-3890"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.radonc.2014.11.017","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T09:20:30Z","timestamp":1416907230000},"page":"96-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["ACE inhibition attenuates radiation-induced cardiopulmonary damage"],"prefix":"10.1016","volume":"114","author":[{"given":"Sonja J.","family":"van der Veen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Ghobadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hette","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan V.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Nagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sytze","family":"Brandenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Langendijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van Luijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Coppes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2014.11.017_b0005","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.radonc.2014.11.017_b0010","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1182\/blood-2010-04-278796","article-title":"Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the childhood cancer survivor study","volume":"117","author":"Castellino","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.radonc.2014.11.017_b0015","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2014.11.017_b0020","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/hrt.2008.149088","article-title":"Radiation induced heart disease: systemic disorders in heart disease","volume":"95","author":"Heidenreich","year":"2009","journal-title":"Heart"},{"key":"10.1016\/j.radonc.2014.11.017_b0025","article-title":"Cardiovascular complications of radiation therapy for thoracic malignancies: the role for non-invasive imaging for detection of cardiovascular disease","author":"Groarke","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.radonc.2014.11.017_b0030","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S1053-4296(03)00026-2","article-title":"Radiation-associated cardiovascular disease: manifestations and management","volume":"13","author":"Adams","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2014.11.017_b0035","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0360-3016(94)00429-O","article-title":"Injury to the lung from cancer therapy: clinical syndromes, measurable endpoints, and potential scoring systems","volume":"31","author":"McDonald","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2013.08.035","article-title":"Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients","author":"Nalbantov","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2014.11.017_b0045","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ijrobp.2007.05.065","article-title":"The impact of heart irradiation on dose-volume effects in the rat lung","volume":"69","author":"van Luijk","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0050","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1158\/0008-5472.CAN-04-3466","article-title":"Pulmonary radiation injury: identification of risk factors associated with regional hypersensitivity","volume":"65","author":"Novakova-Jiresova","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0055","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1158\/0008-5472.CAN-05-0786","article-title":"Radiation damage to the heart enhances early radiation-induced lung function loss","volume":"65","author":"van Luijk","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0060","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijrobp.2005.12.021","article-title":"Relation between radiation-induced whole lung functional loss and regional structural changes in partial irradiated rat lung","volume":"64","author":"van Luijk","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/0284186X.2010.521192","article-title":"Heart irradiation as a risk factor for radiation pneumonitis","volume":"50","author":"Huang","year":"2011","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2014.11.017_b0070","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/thoraxjnl-2011-200346","article-title":"Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension","volume":"67","author":"Ghobadi","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.radonc.2014.11.017_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2012.07.2362","article-title":"Physiological interaction of heart and lung in thoracic irradiation","author":"Ghobadi","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0080","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/j.ijrobp.2011.12.018","article-title":"Acute cardiac impairment associated with concurrent chemoradiotherapy for esophageal cancer: magnetic resonance evaluation","volume":"83","author":"Hatakenaka","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0085","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1161\/CIRCULATIONAHA.104.500546","article-title":"Mechanisms and models in heart failure: the biomechanical model and beyond","volume":"111","author":"Mann","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.radonc.2014.11.017_b0090","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system","volume":"83","author":"Weber","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.radonc.2014.11.017_b0095","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2174\/138161207780618821","article-title":"Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists","volume":"13","author":"Moulder","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.radonc.2014.11.017_b0100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1667\/RR2731.1","article-title":"Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment","volume":"178","author":"Lee","year":"2012","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0105","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.ijrobp.2009.07.1743","article-title":"Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis","volume":"75","author":"Ghosh","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0110","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0360-3016(92)90890-T","article-title":"Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme","volume":"22","author":"Ward","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0245","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1088\/0031-9155\/46\/11\/307","article-title":"Techniques for precision irradiation of the lateral half of the rat cervical spinal cord using 150 MeV protons [corrected]","volume":"46","author":"van Luijk","year":"2001","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2014.11.017_b0120","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1088\/0031-9155\/46\/3\/303","article-title":"Collimator scatter and 2D dosimetry in small proton beams","volume":"46","author":"van Luijk","year":"2001","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2014.11.017_b0125","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ijrobp.2009.08.058","article-title":"Quantifying local radiation-induced lung damage from computed tomography","volume":"76","author":"Ghobadi","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0130","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1172\/JCI31044","article-title":"ECM remodeling in hypertensive heart disease","volume":"117","author":"Berk","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.radonc.2014.11.017_b0135","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1517\/13543784.13.6.643","article-title":"Recent advances in natriuretic peptides in congestive heart failure","volume":"13","author":"Boerrigter","year":"2004","journal-title":"Expert Opin Invest Drugs"},{"key":"10.1016\/j.radonc.2014.11.017_b0140","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM199111283252206","article-title":"Diastolic dysfunction in congestive heart failure","volume":"325","author":"Grossman","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2014.11.017_b0145","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ijrobp.2009.09.064","article-title":"Radiation-related heart disease: current knowledge and future prospects","volume":"76","author":"Darby","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2307\/3576889","article-title":"Endothelial alkaline phosphatase activity loss as an early stage in the development of radiation-induced heart disease in rats","volume":"110","author":"Lauk","year":"1987","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0155","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1158\/0008-5472.CAN-12-1831","article-title":"Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system","volume":"72","author":"Sridharan","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0160","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijrobp.2005.01.029","article-title":"The incidence and functional consequences of RT-associated cardiac perfusion defects","volume":"63","author":"Marks","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0165","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.ijrobp.2012.09.022","article-title":"Subclinical cardiotoxicity detected by strain rate imaging up to 14 months after breast radiation therapy","volume":"85","author":"Erven","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0170","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0360-3016(90)90351-J","article-title":"Captopril reduces collagen and mast cell accumulation in irradiated rat lung","volume":"19","author":"Ward","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0175","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1259\/0007-1285-63-749-349","article-title":"The effect of Captopril on benign and malignant reactions in irradiated rat skin","volume":"63","author":"Ward","year":"1990","journal-title":"Br J Radiol"},{"key":"10.1016\/j.radonc.2014.11.017_b0180","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2307\/3577335","article-title":"Radiation-induced endothelial dysfunction and fibrosis in rat lung: modification by the angiotensin converting enzyme inhibitor CL242817","volume":"117","author":"Ward","year":"1989","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0185","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijrobp.2011.11.013","article-title":"Decreased risk of radiation pneumonitis with incidental concurrent use of Angiotensin-converting enzyme inhibitors and thoracic radiation therapy","volume":"84","author":"Kharofa","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0190","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1172\/JCI110559","article-title":"Inhibition of vascular permeability changes in rats by captopril","volume":"69","author":"Fantone","year":"1982","journal-title":"J Clin Invest"},{"key":"10.1016\/j.radonc.2014.11.017_b0200","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1365-2125.1989.tb05384.x","article-title":"Captopril: a free radical scavenger","volume":"27","author":"Chopra","year":"1989","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.radonc.2014.11.017_b0205","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0022-2828(91)90082-W","article-title":"DNA synthesis in the non-infarcted cardiac interstitium after left coronary artery ligation in the rat: effects of captopril","volume":"23","author":"van Krimpen","year":"1991","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.radonc.2014.11.017_b0210","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/01.RES.69.3.609","article-title":"Effect of angiotensin converting enzyme inhibition on pressure-induced left ventricular hypertrophy in rats","volume":"69","author":"Zierhut","year":"1991","journal-title":"Circ Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0215","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2307\/3578356","article-title":"Effect of captopril on changes in rats\u2019 hearts induced by long-term irradiation","volume":"133","author":"Yarom","year":"1993","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0220","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/cvr\/27.3.341","article-title":"Myocardial fibrosis: functional significance and regulatory factors","volume":"27","author":"Weber","year":"1993","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0225","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvq308","article-title":"Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart","volume":"89","author":"Creemers","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0230","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijrobp.2010.05.017","article-title":"Computed tomography appearance of early radiation injury to the lung: correlation with clinical and dosimetric factors","volume":"81","author":"Jenkins","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2014.11.017_b0235","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1667\/RR0707.1","article-title":"Differential radiation effect in tumor and normal tissue after treatment with ramipril, an angiotensin-converting enzyme inhibitor","volume":"168","author":"Kohl","year":"2007","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2014.11.017_b0240","doi-asserted-by":"crossref","first-page":"djt374","DOI":"10.1093\/jnci\/djt374","article-title":"Angiotensin-converting enzyme inhibitor therapy and colorectal cancer risk","volume":"106","author":"Makar","year":"2014","journal-title":"J Natl Cancer Inst"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814014004964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814014004964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T08:52:35Z","timestamp":1538038355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814014004964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0167814014004964"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2014.11.017","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACE inhibition attenuates radiation-induced cardiopulmonary damage","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2014.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}