{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:39:27Z","timestamp":1791315567156,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["UM 2010-4714"],"award-info":[{"award-number":["UM 2010-4714"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["2012-5506"],"award-info":[{"award-number":["2012-5506"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.radonc.2015.06.023","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T13:24:33Z","timestamp":1436361873000},"page":"417-422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["GABARAPL1 is required for increased EGFR membrane expression during hypoxia"],"prefix":"10.1016","volume":"116","author":[{"given":"Tom G.","family":"Keulers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco B.E.","family":"Schaaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke J.M.","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim G.M.","family":"Savelkouls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Vooijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Bussink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Jutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper M.A.","family":"Rouschop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2015.06.023_b0005","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0959-8049(97)10172-1","article-title":"Variations in tumour oxygen tension (pO2) during accelerated radiotherapy of head and neck carcinoma","volume":"34","author":"Lartigau","year":"1998","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.radonc.2015.06.023_b0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2005.06.038","article-title":"Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study","volume":"77","author":"Nordsmark","year":"2005","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1535-6108(03)00085-0","article-title":"Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene","volume":"3","author":"Pennacchietti","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.radonc.2015.06.023_b0020","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1158\/0008-5472.CAN-10-4049","article-title":"Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer","volume":"71","author":"Chang","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.radonc.2015.06.023_b0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.radonc.2013.04.022","article-title":"Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial","volume":"108","author":"Rademakers","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.critrevonc.2005.12.003","article-title":"Regulation of angiogenesis by hypoxia-inducible factor 1","volume":"59","author":"Hirota","year":"2006","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.radonc.2015.06.023_b0035","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","article-title":"Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.radonc.2015.06.023_b0040","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1083\/jcb.201307185","article-title":"Two phases of disulfide bond formation have differing requirements for oxygen","volume":"203","author":"Koritzinsky","year":"2013","journal-title":"J Cell Biol"},{"key":"10.1016\/j.radonc.2015.06.023_b0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200408003","article-title":"Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response","volume":"167","author":"Lu","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1016\/j.radonc.2015.06.023_b0050","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1096\/fj.02-1184fje","article-title":"The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice","volume":"17","author":"Kojima","year":"2003","journal-title":"Faseb J"},{"key":"10.1016\/j.radonc.2015.06.023_b0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.radonc.2007.04.031","article-title":"Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia","volume":"83","author":"Koritzinsky","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0060","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.radonc.2015.06.023_b0065","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1073\/pnas.1210633110","article-title":"PERK\/eIF2alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS","volume":"110","author":"Rouschop","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.radonc.2015.06.023_b0070","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.radonc.2013.06.015","article-title":"The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia","volume":"108","author":"Schaaf","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1172\/JCI40027","article-title":"The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5","volume":"120","author":"Rouschop","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.radonc.2015.06.023_b0080","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.radonc.2009.06.017","article-title":"The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment","volume":"92","author":"Theys","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0085","doi-asserted-by":"crossref","first-page":"13092","DOI":"10.1073\/pnas.0702387104","article-title":"Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer","volume":"104","author":"Franovic","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.radonc.2015.06.023_b0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.radonc.2013.05.006","article-title":"Interaction of EGFR with the tumour microenvironment: implications for radiation treatment","volume":"108","author":"Nijkamp","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0095","doi-asserted-by":"crossref","first-page":"15106","DOI":"10.1074\/jbc.M111.230896","article-title":"Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression","volume":"286","author":"Chen","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.radonc.2015.06.023_b0100","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1074\/jbc.M509805200","article-title":"GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor","volume":"281","author":"Chen","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.radonc.2015.06.023_b0105","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1046\/j.1471-4159.2000.0750644.x","article-title":"Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction","volume":"75","author":"Wang","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.radonc.2015.06.023_b0110","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.ijrobp.2007.08.032","article-title":"Gene expression profiling to predict outcome after chemoradiation in head and neck cancer","volume":"69","author":"Pramana","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2015.06.023_b0115","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.radonc.2012.02.002","article-title":"The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer","volume":"102","author":"Starmans","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0120","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.radonc.2013.02.001","article-title":"Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models","volume":"106","author":"Stegeman","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0125","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1471-2407-14-130","article-title":"Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors","volume":"14","author":"Hoeben","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2015.06.023_b0130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-8140(99)00102-4","article-title":"Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome","volume":"53","author":"Brizel","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2005.06.038","article-title":"Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study","volume":"77","author":"Nordsmark","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0140","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.regpep.2009.09.002","article-title":"C-terminal processing of GABARAP is not required for trafficking of the angiotensin II type 1A receptor","volume":"159","author":"Alam","year":"2010","journal-title":"Regul Pept"},{"key":"10.1016\/j.radonc.2015.06.023_b0145","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1161\/CIRCRESAHA.108.176594","article-title":"The trafficking protein GABARAP binds to and enhances plasma membrane expression and function of the angiotensin II type 1 receptor","volume":"102","author":"Cook","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.radonc.2015.06.023_b0150","doi-asserted-by":"crossref","first-page":"6655","DOI":"10.1523\/JNEUROSCI.0919-07.2007","article-title":"C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking","volume":"27","author":"Chen","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.radonc.2015.06.023_b0155","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.radonc.2007.04.025","article-title":"Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance","volume":"83","author":"Weppler","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.06.023_b0160","doi-asserted-by":"crossref","first-page":"11557","DOI":"10.1073\/pnas.190133497","article-title":"The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics","volume":"97","author":"Chen","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.radonc.2015.06.023_b0165","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbrc.2004.10.072","article-title":"GEC1, a protein related to GABARAP, interacts with tubulin and GABA(A) receptor","volume":"325","author":"Mansuy","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.radonc.2015.06.023_b0170","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1074\/jbc.M808303200","article-title":"GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect","volume":"284","author":"Chen","year":"2009","journal-title":"J Biol Chem"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814015003163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814015003163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T22:58:41Z","timestamp":1566946721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814015003163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0167814015003163"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2015.06.023","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GABARAPL1 is required for increased EGFR membrane expression during hypoxia","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2015.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}