{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:07:32Z","timestamp":1780693652895,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201741"],"award-info":[{"award-number":["81201741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301960"],"award-info":[{"award-number":["81301960"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272017"],"award-info":[{"award-number":["81272017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008868","name":"Science and Technology Department of Jiangsu Province","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.radonc.2015.10.026","type":"journal-article","created":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T21:45:29Z","timestamp":1447019129000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Phase II study of computed tomography-guided 125I-seed implantation plus chemotherapy for locally recurrent rectal cancer"],"prefix":"10.1016","volume":"118","clinical-trial-number":[{"clinical-trial-number":"nct02423226","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Liangrong","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qicheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2015.10.026_b0005","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0140-6736(94)92206-3","article-title":"Role of circumferential margin involvement in the local recurrence of rectal cancer","volume":"344","author":"Adam","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2015.10.026_b0010","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5858\/2006-130-318-KIIRCC","article-title":"Key issues in reporting common cancer specimens: problems in pathologic staging of colon cancer","volume":"130","author":"Compton","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.radonc.2015.10.026_b0015","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1200\/JCO.2011.35.9539","article-title":"Isolated tumor cells in regional lymph nodes as relapse predictors in stage I and II colorectal cancer","volume":"30","author":"Mescoli","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0020","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0002-9610(99)00080-X","article-title":"Recurrence and survival after surgical management of rectal cancer","volume":"177","author":"Ross","year":"1999","journal-title":"Am J Surg"},{"key":"10.1016\/j.radonc.2015.10.026_b0025","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ijrobp.2013.12.012","article-title":"Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control","volume":"88","author":"Habr-Gama","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2015.10.026_b0030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1053\/j.seminoncol.2007.03.005","article-title":"Surgical management of rectal cancer","volume":"34","author":"Rajput","year":"2007","journal-title":"Semin Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0035","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10350-004-0930-3","article-title":"Surgical salvage of recurrent rectal cancer after transanal excision","volume":"48","author":"Weiser","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.radonc.2015.10.026_b0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/3-540-27449-9_15","article-title":"Operative treatment of locally recurrent rectal cancer","volume":"165","author":"Wiig","year":"2005","journal-title":"Recent Results Cancer Res"},{"key":"10.1016\/j.radonc.2015.10.026_b0045","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1053\/ejso.2001.1115","article-title":"The impact of recurrent rectal cancer on quality of life","volume":"27","author":"Camilleri-Brennan","year":"2001","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0050","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1503\/cjs.025911","article-title":"Intentionally curative treatment of locally recurrent rectal cancer: a systematic review","volume":"56","author":"Tanis","year":"2013","journal-title":"Can J Surg"},{"key":"10.1016\/j.radonc.2015.10.026_b0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.radonc.2015.06.016","article-title":"Can we shorten the overall treatment time in postoperative brachytherapy of endometrial carcinoma? Comparison of two brachytherapy schedules","volume":"116","author":"Rovirosa","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.radonc.2015.06.001","article-title":"Acute toxicity after a diverting stoma and spacer prior to chemoradiation in locally advanced rectal cancer","volume":"116","author":"van der Voort van Zyp","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0065","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.radonc.2014.08.010","article-title":"Intra-fraction uncertainties of MRI guided brachytherapy in patients with cervical cancer","volume":"112","author":"Nomden","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1748-717X-6-138","article-title":"Clinical application of CT-guided (125)I seed interstitial implantation for local recurrent rectal carcinoma","volume":"6","author":"Wang","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0075","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0360-3016(98)00269-7","article-title":"125Iodine brachytherapy for colorectal adenocarcinoma recurrent in the pelvis and paraortics","volume":"42","author":"Martinez-Monge","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2015.10.026_b0080","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.radonc.2014.12.001","article-title":"Severe rectal complications after prostate brachytherapy","volume":"114","author":"Wallner","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.radonc.2013.03.003","article-title":"Three-dimensional summation of rectal doses in brachytherapy combined with external beam radiotherapy for prostate cancer","volume":"107","author":"Kikuchi","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0090","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.radonc.2010.10.002","article-title":"3D CT-based high-dose-rate brachytherapy for cervical cancer: clinical impact on late rectal bleeding and local control","volume":"97","author":"Kang","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0095","unstructured":"NCCN Clinical practice guidelines in Onology, Rectal Cancer, Version 3.2014. Available: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/rectal.pdf."},{"key":"10.1016\/j.radonc.2015.10.026_b0100","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00384-008-0628-4","article-title":"Interstitial permanent implantation of 125I seeds as salvage therapy for re-recurrent rectal carcinoma","volume":"24","author":"Wang","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.radonc.2015.10.026_b0105","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1748-717X-7-114","article-title":"Computed tomography-guided permanent brachytherapy for locoregional recurrent gastric cancer","volume":"7","author":"Shi","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0110","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1470-2045(10)70181-9","article-title":"Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2\/3 non-inferiority study (FIRIS study)","volume":"11","author":"Muro","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0115","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1200\/JCO.2009.27.6055","article-title":"Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer","volume":"28","author":"Peeters","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.radonc.2014.11.021","article-title":"Reirradiation of locally recurrent rectal cancer: a systematic review","volume":"113","author":"Guren","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0125","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1245\/s10434-009-0737-5","article-title":"Locally recurrent rectal cancer: prognostic factors and long-term outcomes of multimodal therapy","volume":"17","author":"Pacelli","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0130","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/cncr.10799","article-title":"Long-term results of reirradiation for patients with recurrent rectal carcinoma","volume":"95","author":"Mohiuddin","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2015.10.026_b0135","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1245\/s10434-008-9896-z","article-title":"Radical resection after IORT-containing multimodality treatment is the most important determinant for outcome in patients treated for locally recurrent rectal cancer","volume":"15","author":"Dresen","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12032-009-9227-7","article-title":"CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy","volume":"27","author":"Wang","year":"2010","journal-title":"Med Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0145","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/1097-0142(19840315)53:6<1354::AID-CNCR2820530623>3.0.CO;2-J","article-title":"Patterns of pelvic recurrence following definitive resections of rectal cancer","volume":"53","author":"Pilipshen","year":"1984","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2015.10.026_b0150","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/bjs.1800720115","article-title":"Local recurrence after potentially curative resection for rectal cancer in a series of 1008 patients","volume":"72","author":"McDermott","year":"1985","journal-title":"Br J Surg"},{"key":"10.1016\/j.radonc.2015.10.026_b0155","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF00298532","article-title":"Analysis of local recurrence rates after surgery alone for rectal cancer","volume":"10","author":"McCall","year":"1995","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.radonc.2015.10.026_b0160","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1200\/JCO.2009.22.0467","article-title":"Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03","volume":"27","author":"Roh","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2015.10.026_b0165","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2015.10.026_b0170","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ijrobp.2006.08.063","article-title":"Comparison of 5-fluorouracil\/leucovorin and capecitabine in preoperative chemoradiotherapy for locally advanced rectal cancer","volume":"67","author":"Kim","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2015.10.026_b0175","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00066-003-0921-7","article-title":"Palliative interstitial HDR brachytherapy for recurrent rectal cancer. Implantation techniques and results","volume":"179","author":"Kolotas","year":"2003","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2015.10.026_b0180","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1016\/j.ijrobp.2011.03.031","article-title":"Delineation of gross tumor volume (GTV) for radiation treatment planning of locally advanced rectal cancer using information from MRI or FDG-PET\/CT: a prospective study","volume":"81","author":"Braendengen","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2015.10.026_b0185","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/bmj.38937.646400.55","article-title":"Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study","volume":"333","year":"2006","journal-title":"BMJ"},{"key":"10.1016\/j.radonc.2015.10.026_b0190","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.ijrobp.2006.02.050","article-title":"Definition and delineation of the clinical target volume for rectal cancer","volume":"65","author":"Roels","year":"2006","journal-title":"Int J Radiat Oncol. Biol. Phys"},{"key":"10.1016\/j.radonc.2015.10.026_b0195","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1259\/bjr\/41321492","article-title":"New developments in MRI for target volume delineation in radiotherapy","volume":"79","author":"Khoo","year":"2006","journal-title":"Br J Radiol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814015005757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814015005757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T17:14:52Z","timestamp":1653498892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814015005757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0167814015005757"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2015.10.026","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phase II study of computed tomography-guided 125I-seed implantation plus chemotherapy for locally recurrent rectal cancer","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2015.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}