{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:19:36Z","timestamp":1782181176918,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NHS Executive"},{"name":"Cancer Research UK Programme Grants","award":["C7224\/A13407"],"award-info":[{"award-number":["C7224\/A13407"]}]},{"name":"National Institute for Health Research Royal Marsden"},{"name":"Institute of Cancer Research Biomedical Research Centre"}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.radonc.2016.06.007","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T21:48:22Z","timestamp":1467236902000},"page":"63-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Contrast enhancement of carotid adventitial vasa vasorum as a biomarker of radiation-induced atherosclerosis"],"prefix":"10.1016","volume":"120","clinical-trial-number":[{"clinical-trial-number":"nct02060643","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Dorothy M.","family":"Gujral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Keung","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoy N.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navtej S.","family":"Chahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxy","family":"Senior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Nutting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2016.06.007_b0005","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1172\/JCI1568","article-title":"Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia","volume":"101","author":"Kwon","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.radonc.2016.06.007_b0010","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S0008-6363(01)00347-9","article-title":"Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia","volume":"51","author":"Herrmann","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.radonc.2016.06.007_b0015","doi-asserted-by":"crossref","first-page":"C13","DOI":"10.1016\/j.jacc.2005.10.065","article-title":"Pathology of the vulnerable plaque","volume":"47","author":"Virmani","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.radonc.2016.06.007_b0020","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jacc.2006.02.068","article-title":"Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization","volume":"48","author":"Feinstein","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.radonc.2016.06.007_b0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1191\/1358863x04vm522oa","article-title":"Effect of contrast enhancement on measurement of carotid artery intimal medial thickness","volume":"9","author":"Macioch","year":"2004","journal-title":"Vasc Med"},{"key":"10.1016\/j.radonc.2016.06.007_b0030","doi-asserted-by":"crossref","first-page":"H450","DOI":"10.1152\/ajpheart.00134.2004","article-title":"The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond","volume":"287","author":"Feinstein","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.radonc.2016.06.007_b0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/scientificamerican0576-58","article-title":"The vascularization of tumors","volume":"234","author":"Folkman","year":"1976","journal-title":"Sci Am"},{"key":"10.1016\/j.radonc.2016.06.007_b0040","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1056\/NEJM198401193100307","article-title":"Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis","volume":"310","author":"Barger","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2016.06.007_b0045","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/ncpcardio1157","article-title":"Imaging of the vasa vasorum","volume":"5","author":"Granada","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1016\/j.radonc.2016.06.007_b0050","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/ejechocard\/jen221","article-title":"Contrast-enhanced ultrasound imaging of periadventitial vasa vasorum in human carotid arteries","volume":"10","author":"Magnoni","year":"2009","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.radonc.2016.06.007_b0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacc.2008.02.082","article-title":"Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity","volume":"52","author":"Coli","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.radonc.2016.06.007_b0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/1358863X07083363","article-title":"Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis?","volume":"12","author":"Shah","year":"2007","journal-title":"Vasc Med"},{"key":"10.1016\/j.radonc.2016.06.007_b0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/STROKEAHA.109.560342","article-title":"Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events","volume":"41","author":"Staub","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.radonc.2016.06.007_b0070","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.ultrasmedbio.2008.04.008","article-title":"Attenuation correction in ultrasound contrast agent imaging: elementary theory and preliminary experimental evaluation","volume":"34","author":"Tang","year":"2008","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.radonc.2016.06.007_b0075","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1098\/rsfs.2011.0026","article-title":"Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability","volume":"1","author":"Tang","year":"2011","journal-title":"Interface Focus"},{"key":"10.1016\/j.radonc.2016.06.007_b0080","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1109\/TUFFC.2010.1487","article-title":"An approximate nonlinear model for time gain compensation of amplitude modulated images of ultrasound contrast agent perfusion","volume":"57","author":"Mari","year":"2010","journal-title":"IEEE Trans Ultrason Ferroelectr Freq Control"},{"key":"10.1016\/j.radonc.2016.06.007_b0085","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ultrasmedbio.2007.11.014","article-title":"Regularized estimation of contrast agent attenuation to improve the imaging of microbubbles in small animal studies","volume":"34","author":"Mule","year":"2008","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.radonc.2016.06.007_b0090","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.ultrasmedbio.2015.02.010","article-title":"Attenuation correction and normalisation for quantification of contrast enhancement in ultrasound images of carotid arteries","volume":"41","author":"Cheung","year":"2015","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.radonc.2016.06.007_b0095","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0301-5629(02)00760-3","article-title":"Carotid artery wall motion estimated from B-mode ultrasound using region tracking and block matching","volume":"29","author":"Golemati","year":"2003","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.radonc.2016.06.007_b0100","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.jacc.2010.09.001","article-title":"2010 ACCF\/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"56","author":"Greenland","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.radonc.2016.06.007_b0105","article-title":"Carotid adventitial vasa vasorum and intima-media thickness in a primary prevention population","author":"Sampson","year":"2014","journal-title":"Echocardiography"},{"key":"10.1016\/j.radonc.2016.06.007_b0110","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1109\/TUFFC.2006.189","article-title":"Nonlinear propagation of ultrasound through microbubble contrast agents and implications for imaging","volume":"53","author":"Tang","year":"2006","journal-title":"IEEE Trans Ultrason Ferroelectr Freq Control"},{"key":"10.1016\/j.radonc.2016.06.007_b0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ultrasmedbio.2009.11.011","article-title":"Effects of nonlinear propagation in ultrasound contrast agent imaging","volume":"36","author":"Tang","year":"2010","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.radonc.2016.06.007_b0120","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/ehjci\/jet243","article-title":"Utility of contrast-enhanced ultrasound for the assessment of the carotid artery wall in patients with Takayasu or giant cell arteritis","volume":"15","author":"Schinkel","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.radonc.2016.06.007_b0125","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1148\/radiol.10101008","article-title":"Correlation of carotid artery atherosclerotic lesion echogenicity and severity at standard US with intraplaque neovascularization detected at contrast-enhanced US","volume":"258","author":"Staub","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2016.06.007_b0130","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1148\/radiol.11110968","article-title":"Dose-dependent artifact in the far wall of the carotid artery at dynamic contrast-enhanced US","volume":"262","author":"Thapar","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2016.06.007_b0135","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ultrasmedbio.2011.12.019","article-title":"Far-wall pseudoenhancement during contrast-enhanced ultrasound of the carotid arteries: clinical description and in vitro reproduction","volume":"38","author":"ten Kate","year":"2012","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.radonc.2016.06.007_b0140","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1161\/01.CIR.102.22.2745","article-title":"Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes","volume":"102","author":"Lindner","year":"2000","journal-title":"Circulation"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814016311574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814016311574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T17:25:35Z","timestamp":1536600335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814016311574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0167814016311574"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2016.06.007","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contrast enhancement of carotid adventitial vasa vasorum as a biomarker of radiation-induced atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2016.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2016 Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}