{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:08:06Z","timestamp":1776352086590,"version":"3.51.2"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence","award":["MOHW106-TDU-B-212-113004"],"award-info":[{"award-number":["MOHW106-TDU-B-212-113004"]}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academia Sinica Taiwan Biobank Stroke Biosignature Project","award":["BM10501010037"],"award-info":[{"award-number":["BM10501010037"]}]},{"name":"NRPB Stroke Clinical Trial Consortium","award":["MOST105-2325-B-039-003"],"award-info":[{"award-number":["MOST105-2325-B-039-003"]}]},{"name":"Tseng-Lien Lin Foundation"},{"name":"Taiwan Brain Disease Foundation"},{"name":"Katsuzo and Kiyo Aoshima Memorial Funds"},{"name":"China Medical University Hospital Cancer Research Center of Excellence","award":["MOHW105-TDU-B-212-134003"],"award-info":[{"award-number":["MOHW105-TDU-B-212-134003"]}]}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.radonc.2017.04.025","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T20:01:49Z","timestamp":1495224109000},"page":"394-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study"],"prefix":"10.1016","volume":"123","author":[{"given":"Chao-Yueh","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Shu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsing-Lung","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Yen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Fu","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuen-Tze","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Ju","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hung","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2017.04.025_b0005","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrendo.2012.29","article-title":"A review of the evidence for and against increased mortality in hypothyroidism","volume":"8","author":"Thvilum","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.radonc.2017.04.025_b0010","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1001\/jama.2010.1786","article-title":"Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism","volume":"304","author":"Rotondi","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.radonc.2017.04.025_b0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijrobp.2005.06.037","article-title":"Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients","volume":"64","author":"Baujat","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.04.025_b0020","first-page":"1029","article-title":"Application study of the Chinese 2008 staging system of nasopharyngeal carcinoma","volume":"28","author":"Lin","year":"2009","journal-title":"Ai Zheng"},{"key":"10.1016\/j.radonc.2017.04.025_b0025","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1056\/NEJM199108293250902","article-title":"Thyroid diseases after treatment of Hodgkin's disease","volume":"325","author":"Hancock","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2017.04.025_b0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0360-3016(01)01688-1","article-title":"Hypothyroidism incidence after multimodality treatment for stage III and IV squamous cell carcinomas of the head and neck","volume":"51","author":"Colevas","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.04.025_b0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0167-8140(92)90192-W","article-title":"Hypothyroidism following radiotherapy for head and neck cancer: multivariate analysis of risk factors","volume":"25","author":"Grande","year":"1992","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.04.025_b0040","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ijrobp.2009.03.011","article-title":"Hypothyroidism after radiotherapy for nasopharyngeal cancer patients","volume":"76","author":"Wu","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.04.025_b0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ando.2010.06.005","article-title":"Thyroid toxicity after radiotherapy of nasopharyngeal carcinoma","volume":"72","author":"Siala","year":"2011","journal-title":"Ann Endocrinol"},{"key":"10.1016\/j.radonc.2017.04.025_b0050","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s12032-013-0710-9","article-title":"Hypothalamic-pituitary-thyroid dysfunction induced by intensity-modulated radiotherapy (IMRT) for adult patients with nasopharyngeal carcinoma","volume":"30","author":"Huang","year":"2013","journal-title":"Med Oncol"},{"key":"10.1016\/j.radonc.2017.04.025_b0055","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1016\/j.clon.2016.05.004","article-title":"Dosimetric predictors of hypothyroidism after radical intensity-modulated radiation therapy for non-metastatic nasopharyngeal carcinoma","volume":"28","author":"Lee","year":"2016","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.radonc.2017.04.025_b0060","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/1754-9485.12074","article-title":"Evaluation of clinical hypothyroidism risk due to irradiation of thyroid and pituitary glands in radiotherapy of nasopharyngeal cancer patients","volume":"57","author":"Lin","year":"2013","journal-title":"J Med Imaging Radiat Oncol"},{"key":"10.1016\/j.radonc.2017.04.025_b0065","unstructured":"Database NHIR, Taiwan. http:\/\/nhird.nhri.org.tw\/en\/index.html. Accessed May 21, 2015."},{"key":"10.1016\/j.radonc.2017.04.025_b0070","first-page":"1","article-title":"Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey","volume":"4","author":"Liu","year":"2006","journal-title":"J Health Manag"},{"key":"10.1016\/j.radonc.2017.04.025_b0075","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0950-351X(88)80065-X","article-title":"Radiation and thyroid disease","volume":"2","author":"DeGroot","year":"1988","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"10.1016\/j.radonc.2017.04.025_b0080","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0360-3016(95)00019-U","article-title":"Thyroid abnormalities after therapeutic external radiation","volume":"31","author":"Hancock","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.04.025_b0085","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2012.08.013","article-title":"A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma","volume":"104","author":"Peng","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.04.025_b0090","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11102-008-0088-4","article-title":"Hypopituitarism following radiotherapy","volume":"12","author":"Darzy","year":"2009","journal-title":"Pituitary"},{"key":"10.1016\/j.radonc.2017.04.025_b0095","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2307\/3575908","article-title":"The effect of single-dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells","volume":"94","author":"Hochberg","year":"1983","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2017.04.025_b0100","first-page":"661","article-title":"Reduced hypothalamic blood flow after radiation treatment of nasopharyngeal cancer: SPECT studies in 34 patients","volume":"12","author":"Chieng","year":"1991","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.radonc.2017.04.025_b0105","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/1097-0142(20000801)89:3<690::AID-CNCR26>3.0.CO;2-S","article-title":"Nasopharyngeal carcinoma in childhood and adolescence: a single-institution experience with combined therapy","volume":"89","author":"Zubizarreta","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2017.04.025_b0110","first-page":"3227","article-title":"Abnormalities of the thyroid in survivors of Hodgkin\u2019s disease: data from the Childhood Cancer Survivor Study","volume":"85","author":"Sklar","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.radonc.2017.04.025_b0115","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.ijrobp.2007.01.029","article-title":"Primary and central hypothyroidism after radiotherapy for head-and-neck tumors","volume":"68","author":"Bhandare","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.04.025_b0120","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hed.2880130508","article-title":"Thyroid-stimulating hormone levels after radiotherapy and combined therapy for head and neck cancer","volume":"13","author":"Weissler","year":"1991","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2017.04.025_b0125","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.oraloncology.2013.03.450","article-title":"A prospective longitudinal study on endocrine dysfunction following treatment of laryngeal or hypopharyngeal carcinoma","volume":"49","author":"Lo Galbo","year":"2013","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2017.04.025_b0130","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0360-3016(93)E0112-J","article-title":"Thyroid dysfunction following radiotherapy for head and neck cancer","volume":"31","author":"Turner","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.04.025_b0135","first-page":"244","article-title":"Hypothyroidism: an update","volume":"86","author":"Gaitonde","year":"2012","journal-title":"Am Fam Physician"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017303675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017303675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T17:24:16Z","timestamp":1535822656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814017303675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0167814017303675"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2017.04.025","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2017.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}