{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:58:59Z","timestamp":1780581539632,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Newman Family Professorship Fund"}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.radonc.2017.08.002","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T13:30:20Z","timestamp":1502890220000},"page":"68-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Sparing all salivary glands with IMRT for head and neck cancer: Longitudinal study of patient-reported xerostomia and head-and-neck quality of life"],"prefix":"10.1016","volume":"126","author":[{"given":"Peter G.","family":"Hawkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis P.","family":"Worden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Swiecicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Mierzwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Spector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Eisbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2017.08.002_b0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/1097-0347(200102)23:2<113::AID-HED1006>3.0.CO;2-W","article-title":"Health-related quality of life three years after diagnosis of head and neck cancer\u2013a longitudinal study","volume":"23","author":"Hammerlid","year":"2001","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2017.08.002_b0010","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ijrobp.2007.04.021","article-title":"Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer","volume":"69","author":"Jellema","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.radonc.2005.10.002","article-title":"Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?","volume":"77","author":"Jellema","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0020","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0025","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0360-3016(01)01717-5","article-title":"Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region","volume":"51","author":"Roesink","year":"2001","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0030","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ijrobp.2004.12.076","article-title":"Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy","volume":"62","author":"Blanco","year":"2005","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0167-8140(02)00013-0","article-title":"Preservation of parotid function with uncomplicated conformal radiotherapy","volume":"63","author":"Maes","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0040","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijrobp.2006.09.021","article-title":"The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy","volume":"67","author":"Li","year":"2007","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0045","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1200\/JCO.2007.11.5501","article-title":"Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients","volume":"25","author":"Kam","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (parsport): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0055","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ijrobp.2006.06.013","article-title":"Xerostomia and quality of life after intensity-modulated radiotherapy vs. Conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial","volume":"66","author":"Pow","year":"2006","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.radonc.2012.07.001","article-title":"Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: a randomized controlled trial","volume":"104","author":"Gupta","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0065","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analyses of normal tissue effects in the clinic (quantec): an introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0070","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","article-title":"Radiotherapy dose-volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0075","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0360-3016(01)01512-7","article-title":"Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer","volume":"50","author":"Eisbruch","year":"2001","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0080","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijrobp.2011.04.020","article-title":"Treatment planning constraints to avoid xerostomia in head-and-neck radiotherapy: an independent test of quantec criteria using a prospectively collected dataset","volume":"82","author":"Moiseenko","year":"2012","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0085","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3109\/0284186X.2013.831186","article-title":"The quantec criteria for parotid gland dose and their efficacy to prevent moderate to severe patient-rated xerostomia","volume":"53","author":"Beetz","year":"2014","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0090","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijrobp.2006.05.002","article-title":"Grading xerostomia by physicians or by patients after intensity-modulated radiotherapy of head-and-neck cancer","volume":"66","author":"Meirovitz","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0095","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1200\/JCO.2015.63.0830","article-title":"Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial","volume":"34","author":"Basch","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0100","series-title":"Textbook and color atlas of salivary gland pathology: diagnosis and management","author":"Brennan","year":"2013"},{"key":"10.1016\/j.radonc.2017.08.002_b0105","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev.ph.57.030195.002555","article-title":"In defense of the oral cavity: structure, biosynthesis, and function of salivary mucins","volume":"57","author":"Tabak","year":"1995","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.radonc.2017.08.002_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0714.1982.tb00138.x","article-title":"Role of salivary mucins in the protection of the oral cavity","volume":"11","author":"Tabak","year":"1982","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.radonc.2017.08.002_b0115","doi-asserted-by":"crossref","first-page":"13165","DOI":"10.1038\/srep13165","article-title":"Patient- and therapy-related factors associated with the incidence of xerostomia in nasopharyngeal carcinoma patients receiving parotid-sparing helical tomotherapy","volume":"5","author":"Lee","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.radonc.2017.08.002_b0120","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.ijrobp.2010.07.1990","article-title":"Impact of salivary gland dosimetry on post-imrt recovery of saliva output and xerostomia grade for head-and-neck cancer patients treated with or without contralateral submandibular gland sparing: a longitudinal study","volume":"81","author":"Wang","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0125","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radonc.2006.02.017","article-title":"Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer","volume":"78","author":"Saarilahti","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.radonc.2012.03.004","article-title":"Ntcp models for patient-rated xerostomia and sticky saliva after treatment with intensity modulated radiotherapy for head and neck cancer: the role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0135","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.radonc.2011.11.006","article-title":"External validation of three dimensional conformal radiotherapy based ntcp models for patient-rated xerostomia and sticky saliva among patients treated with intensity modulated radiotherapy","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.radonc.2011.05.010","article-title":"Development of ntcp models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva: the role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0145","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ijrobp.2007.12.033","article-title":"Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy","volume":"72","author":"Murdoch-Kinch","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0150","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1200\/JCO.2009.24.6199","article-title":"Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results","volume":"28","author":"Feng","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0155","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0889-8588(05)70097-6","article-title":"Quality of life assessment in head and neck cancer patients","volume":"13","author":"Terrell","year":"1999","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.radonc.2017.08.002_b0160","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archotol.124.9.964","article-title":"Long-term quality of life after treatment of laryngeal cancer. The veterans affairs laryngeal cancer study group","volume":"124","author":"Terrell","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.radonc.2017.08.002_b0165","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1001\/archotol.1997.01900100101014","article-title":"Head and neck cancer-specific quality of life: instrument validation","volume":"123","author":"Terrell","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.radonc.2017.08.002_b0170","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2307\/1267787","article-title":"On some criteria for estimating the order of a markov chain","volume":"23","author":"Katz","year":"1981","journal-title":"Technometrics"},{"key":"10.1016\/j.radonc.2017.08.002_b0175","series-title":"Information theory and an extension of the maximum likelihood principle Selected papers of hirotugu akaike","author":"Akaike","year":"1998"},{"key":"10.1016\/j.radonc.2017.08.002_b0180","series-title":"Intuitive biostatistics","author":"Motulsky","year":"1995"},{"key":"10.1016\/j.radonc.2017.08.002_b0185","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2307\/1937887","article-title":"Multicollinearity in regression analysis: the problem revisited","author":"Farrar","year":"1967","journal-title":"Rev Econ Stat"},{"key":"10.1016\/j.radonc.2017.08.002_b0190","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2011.09.004","article-title":"Reducing xerostomia after chemo-imrt for head-and-neck cancer: Beyond sparing the parotid glands","volume":"83","author":"Little","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.08.002_b0195","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3109\/0284186X.2011.640348","article-title":"Submandibular gland-sparing intensity modulated radiotherapy in the treatment of head and neck cancer: sites of locoregional relapse and survival","volume":"51","author":"Collan","year":"2012","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0200","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s13014-014-0255-x","article-title":"Submandibular gland-sparing radiation therapy for locally advanced oropharyngeal squamous cell carcinoma: patterns of failure and xerostomia outcomes","volume":"9","author":"Gensheimer","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0205","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2013.10.010","article-title":"Delineation of the neck node levels for head and neck tumors: a 2013 update. Dahanca, eortc, hknpcsg, ncic ctg, ncri, rtog, trog consensus guidelines","volume":"110","author":"Gregoire","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0210","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2008.04.008","article-title":"Sparing the contralateral submandibular gland in oropharyngeal cancer patients: a planning study","volume":"89","author":"Houweling","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.08.002_b0215","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hed.23928","article-title":"Safety of contralateral submandibular gland sparing in locally advanced oropharyngeal cancers: a multicenter review","volume":"38","author":"Robin","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2017.08.002_b0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<207::AID-HED1>3.0.CO;2-9","article-title":"Prognostic significance of the distribution of neck node metastasis from oral carcinoma","volume":"22","author":"Kowalski","year":"2000","journal-title":"Head Neck"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017325021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017325021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T18:01:45Z","timestamp":1547748105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814017325021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0167814017325021"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2017.08.002","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sparing all salivary glands with IMRT for head and neck cancer: Longitudinal study of patient-reported xerostomia and head-and-neck quality of life","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2017.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}