{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:03:32Z","timestamp":1783742612181,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.radonc.2017.09.006","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T16:45:10Z","timestamp":1506185110000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Patient-specific bolus for range shifter air gap reduction in intensity-modulated proton therapy of head-and-neck cancer studied with Monte Carlo based plan optimization"],"prefix":"10.1016","volume":"128","author":[{"given":"Steven","family":"Michiels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Barrag\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Souris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Poels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Crijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond","family":"Sterpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Nuyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Haustermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Depuydt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2017.09.006_b0005","doi-asserted-by":"crossref","first-page":"096702","DOI":"10.1088\/0034-4885\/79\/9\/096702","article-title":"Nuclear physics in particle therapy: a review","volume":"79","author":"Durante","year":"2016","journal-title":"Rep Prog Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0010","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijrobp.2016.10.045","article-title":"Establishing evidence-based indications for proton therapy: an overview of current clinical trials","volume":"97","author":"Mishra","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0015","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.ijrobp.2010.05.012","article-title":"Potential benefits of scanned intensity-modulated proton therapy versus advanced photon therapy with regard to sparing of the salivary glands in oropharyngeal cancer","volume":"79","author":"Van De Water","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.radonc.2016.08.020","article-title":"Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial","volume":"121","author":"Eekers","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0025","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1088\/0031-9155\/53\/6\/016","article-title":"Comparison between the lateral penumbra of a collimated double-scattered beam and uncollimated scanning beam in proton radiotherapy","volume":"53","author":"Safai","year":"2008","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2017.09.006_b0030","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1088\/0031-9155\/55\/23\/S10","article-title":"Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency","volume":"55","author":"Titt","year":"2010","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2017.09.006_b0035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.radonc.2017.02.008","article-title":"Supine craniospinal irradiation in pediatric patients by proton pencil beam scanning","volume":"123","author":"Farace","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0040","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.1088\/0031-9155\/60\/21\/8601","article-title":"Characterization and validation of a Monte Carlo code for independent dose calculation in proton therapy treatments with pencil beam scanning","volume":"60","author":"Fracchiolla","year":"2015","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2017.09.006_b0045","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1118\/1.4933245","article-title":"Comparison of organ-at-risk sparing and plan robustness for spot-scanning proton therapy and volumetric modulated arc photon therapy in head-and-neck cancer","volume":"42","author":"Barten","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijrobp.2014.05.005","article-title":"Development and clinical implementation of a universal bolus to maintain spot size during delivery of base of skull pencil beam scanning proton therapy","volume":"90","author":"Both","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2017.04.027","article-title":"Prompt gamma imaging for in vivo range verification of pencil beam scanning proton therapy","author":"Xie","year":"2017","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.radonc.2016.07.011","article-title":"Clinical implementation of 3D printing in the construction of patient specific bolus for electron beam radiotherapy for non-melanoma skin cancer","volume":"121","author":"Canters","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0065","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1118\/1.4962033","article-title":"Towards 3D printed multifunctional immobilization for proton therapy : Initial materials characterization","volume":"10","author":"Michiels","year":"2016","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.radonc.2016.04.038","article-title":"The price of robustness; impact of worst-case optimization on organ-at-risk dose and complication probability in intensity-modulated proton therapy for oropharyngeal cancer patients","volume":"120","author":"van de Water","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0075","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.ijrobp.2013.09.014","article-title":"Dose uncertainties in IMPT for oropharyngeal cancer in the presence of anatomical, range, and setup errors","volume":"87","author":"Kraan","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0080","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2016.02.016","article-title":"Evaluation of robustness to setup and range uncertainties for head and neck patients treated with pencil beam scanning proton therapy","volume":"95","author":"Malyapa","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijrobp.2016.02.035","article-title":"Robustness recipes for minimax robust optimization in intensity modulated proton therapy for oropharyngeal cancer patients","volume":"95","author":"Van Der Voort","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0090","doi-asserted-by":"crossref","unstructured":"ICRU report 83. Prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT). vol. 10. Oxford, UK: Oxford University Press; 2010.","DOI":"10.1093\/jicru\/ndq002"},{"key":"10.1016\/j.radonc.2017.09.006_b0095","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1118\/1.4943377","article-title":"Fast multi-purpose Monte Carlo simulation for proton therapy using multi- and many-core CPU architectures","volume":"43","author":"Souris","year":"2016","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0100","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1088\/0031-9155\/56\/16\/008","article-title":"A Monte Carlo pencil beam scanning model for proton treatment plan simulation using GATE\/GEANT4","volume":"56","author":"Grevillot","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2017.09.006_b0105","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1088\/0031-9155\/45\/2\/314","article-title":"Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions","volume":"45","author":"Schneider","year":"2000","journal-title":"Phys Med Biol Phys Med Biol"},{"key":"10.1016\/j.radonc.2017.09.006_b0110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10107-004-0559-y","article-title":"On the implementation of a primal-dual interior point filter line search algorithm for large-scale nonlinear programming","volume":"106","author":"W\u00e4chter","year":"2006","journal-title":"Math Program"},{"key":"10.1016\/j.radonc.2017.09.006_b0115","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.1088\/0031-9155\/56\/22\/002","article-title":"GPU-based fast Monte Carlo simulation for radiotherapy dose calculation","volume":"56","author":"Jia","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2017.09.006_b0120","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2009.07.1708","article-title":"Parotid gland function after radiotherapy: the combined Michigan and Utrecht experience","volume":"78","author":"Dijkema","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.radonc.2012.03.004","article-title":"NTCP models for patient-rated xerostomia and sticky saliva after treatment with intensity modulated radiotherapy for head and neck cancer: The role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.radonc.2011.08.009","article-title":"Predictive modelling for swallowing dysfunction after primary (chemo) radiation: results of a prospective observational study","volume":"105","author":"Christianen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0135","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0360-3016(98)00239-9","article-title":"Volumetric and dosimetric evaluation of radiation treatment plans: radiation conformity index","volume":"42","author":"Kn\u00f6\u00f6s","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0140","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1118\/1.3556559","article-title":"Minimax optimization for handling range and setup uncertainties in proton therapy","volume":"38","author":"Fredriksson","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0145","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1118\/1.3021139","article-title":"Reducing the sensitivity of IMPT treatment plans to setup errors and range uncertainties via probabilistic treatment planning","volume":"36","author":"Unkelbach","year":"2009","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0150","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1118\/1.1984263","article-title":"A phantom evaluation of a stereo-vision surface imaging system for radiotherapy patient setup","volume":"32","author":"Bert","year":"2005","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0155","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.ijrobp.2005.11.008","article-title":"Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patients","volume":"64","author":"Bert","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.09.006_b0160","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.radonc.2016.08.022","article-title":"Toward a model-based patient selection strategy for proton therapy: external validation of photon-derived normal tissue complication probability models in a head and neck proton therapy cohort","volume":"121","author":"Blanchard","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0165","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2013.05.007","article-title":"Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach","volume":"107","author":"Langendijk","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.09.006_b0170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2015.10.004","article-title":"The quest for evidence for proton therapy: model-based approach and precision medicine","volume":"95","author":"Widder","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017325689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017325689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T12:53:36Z","timestamp":1560516816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814017325689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0167814017325689"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2017.09.006","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient-specific bolus for range shifter air gap reduction in intensity-modulated proton therapy of head-and-neck cancer studied with Monte Carlo based plan optimization","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2017.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}