{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:35:06Z","timestamp":1768433706192,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C13530\/A10424"],"award-info":[{"award-number":["C13530\/A10424"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009855","name":"Roy Castle Lung Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009855","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Mick Knighton Mesothelioma Research Fund"},{"name":"Welton Trust"},{"name":"Garfield Weston Trust"},{"DOI":"10.13039\/100011088","name":"UCLH Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011088","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Health\u2019s NIHR Biomedical Research Centre\u2019s"},{"name":"CRUK Lung Cancer Centre of Excellence"},{"name":"CRUK\/EPSRC Cancer Imaging Centre"},{"name":"Cancer Research UK Centres Network Accelerator Award Grant","award":["A21993"],"award-info":[{"award-number":["A21993"]}]}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.radonc.2017.11.003","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T14:48:00Z","timestamp":1511794080000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Long term radiological features of radiation-induced lung damage"],"prefix":"10.1016","volume":"126","author":[{"given":"Catarina","family":"Veiga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Landau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie R.","family":"McClelland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Ledermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hawkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam M.","family":"Janes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Devaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2017.11.003_b0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.radonc.2015.07.033","article-title":"CT characteristics allow identification of patient-specific susceptibility for radiation-induced lung damage","volume":"117","author":"Defraene","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.radonc.2012.02.003","article-title":"The features of radiation induced lung fibrosis related with dosimetric parameters","volume":"102","author":"Oh","year":"2012","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0015","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1148\/radiol.2213992043","article-title":"Correlation between lung fibrosis and radiation therapy dose after concurrent radiation therapy and chemotherapy for limited small cell lung cancer","volume":"221","author":"Rosen","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2017.11.003_b0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3857\/roj.2014.32.1.43","article-title":"CT-based quantitative evaluation of radiation-induced lung fibrosis: a study of interobserver and intraobserver variations","volume":"32","author":"Heo","year":"2014","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.radonc.2017.11.003_b0025","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/00004728-198609000-00004","article-title":"Assessment of acute radiation-induced pulmonary changes using computed tomography","volume":"10","author":"Mah","year":"1986","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.radonc.2017.11.003_b0030","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2214\/ajr.178.6.1781383","article-title":"Radiation injury of the lung after three-dimensional conformal radiation therapy","volume":"178","author":"Koenig","year":"2002","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.radonc.2017.11.003_b0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijrobp.2009.04.019","article-title":"Predictive factors of late radiation fibrosis: a prospective study in non-small cell lung cancer","volume":"77","author":"Mazeron","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.11.003_b0040","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3109\/0284186X.2013.813074","article-title":"Quantification of radiation-induced lung damage with CT scans: the possible benefit for radiogenomics","volume":"52","author":"Ruysscher","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3322\/caac.21349","article-title":"Cancer treatment and survivorship statistics, 2016","volume":"66","author":"Miller","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2017.11.003_b0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1470-2045(14)71207-0","volume":"16","author":"Bradley","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0055","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.ijrobp.2016.03.031","article-title":"IDEAL-CRT: a phase 1\/2 trial of isotoxic dose-escalated radiation therapy and concurrent chemotherapy in patients with stage II\/III non-small cell lung cancer","volume":"95","author":"Landau","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.11.003_b0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijrobp.2010.09.004","article-title":"Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group","volume":"82","author":"Machtay","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.11.003_b0065","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1002\/cncr.26080","article-title":"Phase II study of high-dose proton therapy with concurrent chemotherapy for unresectable stage III non-small cell lung cancer","volume":"117","author":"Chang","year":"2011","journal-title":"Cancer"},{"issue":"50","key":"10.1016\/j.radonc.2017.11.003_b0070","first-page":"2939","article-title":"SOCCAR: a randomised phase II trial comparing sequential versus concurrent chemotherapy and radical hypofractionated radiotherapy in patients with inoperable stage III Non-Small Cell Lung Cancer and good performance status","volume":"2014","author":"Maguire","year":"1990","journal-title":"Eur J Cancer Oxf Engl"},{"key":"10.1016\/j.radonc.2017.11.003_b0075","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1164\/ajrccm.157.4.nhlbi-10","article-title":"Lung inflammation and fibrosis","volume":"157","author":"Ward","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.radonc.2017.11.003_b0080","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2214\/ajr.150.4.765","article-title":"CT appearance of acute radiation-induced injury in the lung","volume":"150","author":"Ikezoe","year":"1988","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.radonc.2017.11.003_b0085","first-page":"985","article-title":"Effects of radiation therapy on the lung: radiologic appearances and differential diagnosis","volume":"24","author":"Choi","year":"2004","journal-title":"Radiogr Rev Publ Radiol Soc N Am Inc"},{"key":"10.1016\/j.radonc.2017.11.003_b0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00004728-198402000-00003","article-title":"Radiation-induced pulmonary change: CT findings","volume":"8","author":"Libshitz","year":"1984","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.radonc.2017.11.003_b0095","first-page":"83","article-title":"Radiation-induced lung disease and the impact of radiation methods on imaging features","volume":"20","author":"Park","year":"2000","journal-title":"Radiogr Rev Publ Radiol Soc N Am Inc"},{"key":"10.1016\/j.radonc.2017.11.003_b0100","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.2214\/ajr.182.5.1821123","article-title":"Radiation injury after hypofractionated stereotactic radiotherapy for peripheral small lung tumors: serial changes on CT","volume":"182","author":"Takeda","year":"2004","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.radonc.2017.11.003_b0105","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1102\/1470-7330.2006.9095","article-title":"Radiation injury: imaging findings in the chest, abdomen and pelvis after therapeutic radiation","volume":"6","author":"Iyer","year":"2006","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.radonc.2017.11.003_b0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejrad.2009.10.029","article-title":"Radiation injury of the lung after stereotactic body radiation therapy (SBRT) for lung cancer: a timeline and pattern of CT changes","volume":"79","author":"Linda","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.radonc.2017.11.003_b0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1148\/radiology.198.1.8539368","article-title":"Juxtaphrenic peak in upper and middle lobe volume loss: assessment with CT","volume":"198","author":"Davis","year":"1996","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2017.11.003_b0120","first-page":"37","article-title":"Radiation-induced lung injury. Assessment, management, and prevention","volume":"22","author":"Ghafoori","year":"2008","journal-title":"Oncol Williston Park N"},{"key":"10.1016\/j.radonc.2017.11.003_b0125","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijrobp.2004.02.066","article-title":"Bronchial stenosis: an underreported complication of high-dose external beam radiotherapy for lung cancer?","volume":"61","author":"Miller","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.11.003_b0130","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/mpo.2950110210","article-title":"Radiation-induced pneumothorax","volume":"11","author":"Epstein","year":"1983","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0135","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3390\/cancers7020820","article-title":"Complications from stereotactic body radiotherapy for lung cancer","volume":"7","author":"Kang","year":"2015","journal-title":"Cancers"},{"key":"10.1016\/j.radonc.2017.11.003_b0140","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ijrobp.2013.06.2055","article-title":"Retrospective cohort study of bronchial doses and radiation-induced atelectasis after stereotactic body radiation therapy of lung tumors located close to the bronchial tree","volume":"87","author":"Karlsson","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.11.003_b0145","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1148\/rg.313105096","article-title":"Lung abnormalities at multimodality imaging after radiation therapy for non-small cell lung cancer","volume":"31","author":"Larici","year":"2011","journal-title":"RadioGraphics"},{"key":"10.1016\/j.radonc.2017.11.003_b0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0262-8856(00)00052-4","article-title":"Reconstructing a 3D structure from serial histological sections","volume":"19","author":"Ourselin","year":"2001","journal-title":"Image Vis Comput"},{"key":"10.1016\/j.radonc.2017.11.003_b0155","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.rcl.2005.01.010","article-title":"High-resolution CT of the lung: patterns of disease and differential diagnoses","volume":"43","author":"Gotway","year":"2005","journal-title":"Radiol Clin North Am"},{"key":"10.1016\/j.radonc.2017.11.003_b0160","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.radonc.2011.12.018","article-title":"Radiographic changes after lung stereotactic ablative radiotherapy (SABR) \u2013 Can we distinguish recurrence from fibrosis? A systematic review of the literature","volume":"102","author":"Huang","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0165","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.diii.2012.06.006","article-title":"CT appearance of pulmonary carcinomas after stereotactic radiation therapy","volume":"94","author":"Bibault","year":"2013","journal-title":"Diagn Interv Imaging"},{"key":"10.1016\/j.radonc.2017.11.003_b0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1148\/rg.271065073","article-title":"Lines and stripes: where did they go? \u2014 From conventional radiography to CT","volume":"27","author":"Gibbs","year":"2007","journal-title":"RadioGraphics"},{"key":"10.1016\/j.radonc.2017.11.003_b0175","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/pgmj.2005.044735","article-title":"Extrinsic allergic alveolitis: comparative study of the bronchoalveolar lavage profiles and radiological presentation","volume":"82","author":"Sterclova","year":"2006","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.radonc.2017.11.003_b0180","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1148\/radiology.189.3.8234692","article-title":"Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation","volume":"189","author":"Remy-Jardin","year":"1993","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2017.11.003_b0185","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1148\/radiology.188.1.8511299","article-title":"Parenchymal opacification in chronic infiltrative lung diseases: CT-pathologic correlation","volume":"188","author":"Leung","year":"1993","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2017.11.003_b0190","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1378\/chest.111.4.1061","article-title":"Pulmonary radiation injury","volume":"111","author":"Movsas","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.radonc.2017.11.003_b0195","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2017.11.003_b0200","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) 4.03; 2009."},{"key":"10.1016\/j.radonc.2017.11.003_b0205","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1088\/0031-9155\/59\/18\/5387","article-title":"Lung texture in serial thoracic CT scans: correlation with radiologist-defined severity of acute changes following radiation therapy","volume":"59","author":"Cunliffe","year":"2014","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2017.11.003_b0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lungcan.2009.09.006","article-title":"Early and late lung radiographic injury following stereotactic body radiation therapy (SBRT)","volume":"69","author":"Trovo","year":"2010","journal-title":"Lung Cancer Amst Neth"},{"key":"10.1016\/j.radonc.2017.11.003_b0215","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1148\/radiol.2301021226","article-title":"Evaluation of lung injury after three-dimensional conformal stereotactic radiation therapy for solitary lung tumors: CT appearance","volume":"230","author":"Aoki","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2017.11.003_b0225","series-title":"Challenges in the registration of serial CT images from lung radiotherapy patients","author":"Veiga","year":"2016"},{"key":"10.1016\/j.radonc.2017.11.003_b0230","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijrobp.2016.04.033","article-title":"A voxel-based approach to explore local dose differences associated with radiation-induced lung damage","volume":"96","author":"Palma","year":"2016","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0235","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijrobp.2017.04.026","article-title":"The impact of cardiac radiation dosimetry on survival after radiation therapy for non-small cell lung cancer","volume":"99","author":"Vivekanandan","year":"2017","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0240","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.semradonc.2017.04.009","article-title":"Thoracic radiation normal tissue injury","volume":"27","author":"Simone","year":"2017","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0245","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2015.07.017","article-title":"A new CT-based method to quantify radiation-induced lung damage in patients","volume":"117","author":"Ghobadi","year":"2015","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0250","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.ijrobp.2014.11.030","article-title":"Lung texture in serial thoracic computed tomography scans: correlation of radiomics-based features with radiation therapy dose and radiation pneumonitis development","volume":"91","author":"Cunliffe","year":"2015","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0255","doi-asserted-by":"crossref","first-page":"S938","DOI":"10.1016\/S0167-8140(17)32244-2","article-title":"EP-1712: quantification of radiotherapy-induced mediastinum changes using serial CT imaging","volume":"123","author":"Veiga","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2017.11.003_b0260","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.ijrobp.2017.06.045","article-title":"Quantification of radiation therapy-induced diaphragmatic changes using serial CT imaging","volume":"99","author":"Veiga","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017327019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814017327019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T19:25:42Z","timestamp":1535225142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814017327019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0167814017327019"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2017.11.003","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long term radiological features of radiation-induced lung damage","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2017.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}