{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:50:04Z","timestamp":1791654604682,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC31570497"],"award-info":[{"award-number":["NSFC31570497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31322003"],"award-info":[{"award-number":["31322003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270152"],"award-info":[{"award-number":["31270152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.radonc.2018.04.023","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T12:41:18Z","timestamp":1525437678000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":116,"title":["Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy"],"prefix":"10.1016","volume":"129","author":[{"given":"Jin","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiMin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiYue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongWei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoJun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.radonc.2018.04.023_b0005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother Oncol"},{"issue":"7","key":"10.1016\/j.radonc.2018.04.023_b0010","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/CAD.0b013e3283462086","article-title":"Oral mucositis","volume":"22","author":"Sonis","year":"2011","journal-title":"Anticancer Drugs"},{"issue":"8","key":"10.1016\/j.radonc.2018.04.023_b0015","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1634\/theoncologist.2008-0024","article-title":"Radiation treatment breaks and ulcerative mucositis in head and neck cancer","volume":"13","author":"Russo","year":"2008","journal-title":"Oncologist"},{"key":"10.1016\/j.radonc.2018.04.023_b0020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fonc.2017.00089","article-title":"Radiation-induced oral mucositis","volume":"7","author":"Maria","year":"2017","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.radonc.2018.04.023_b0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc1318","article-title":"The pathobiology of mucositis","volume":"4","author":"Sonis","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"10.1016\/j.radonc.2018.04.023_b0030","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.tripleo.2009.11.015","article-title":"Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study","volume":"109","author":"Napenas","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"5","key":"10.1016\/j.radonc.2018.04.023_b0035","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00520-011-1190-0","article-title":"Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia","volume":"20","author":"de Mendonca","year":"2012","journal-title":"Support Care Cancer"},{"issue":"2","key":"10.1016\/j.radonc.2018.04.023_b0040","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/SPC.0000000000000053","article-title":"Can the oral microflora affect oral ulcerative mucositis?","volume":"8","author":"Laheij","year":"2014","journal-title":"Curr Opin Support Palliat Care"},{"issue":"12","key":"10.1016\/j.radonc.2018.04.023_b0045","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1007\/s00520-012-1463-2","article-title":"Oral bacteria and yeasts in relationship to oral ulcerations in hematopoietic stem cell transplant recipients","volume":"20","author":"Laheij","year":"2012","journal-title":"Support Care Cancer"},{"issue":"1","key":"10.1016\/j.radonc.2018.04.023_b0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tripleo.2005.12.016","article-title":"Relationship between mucositis and changes in oral microflora during cancer chemotherapy","volume":"103","author":"Napenas","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"10.1016\/j.radonc.2018.04.023_b0055","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.4317\/medoral.19934","article-title":"Changes in microflora in dental plaque from cancer patients undergoing chemotherapy and the relationship of these changes with mucositis: A pilot study","volume":"20","author":"Vozza","year":"2015","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"4","key":"10.1016\/j.radonc.2018.04.023_b0060","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ismej.2010.160","article-title":"BIPES, a cost-effective high-throughput method for assessing microbial diversity","volume":"5","author":"Zhou","year":"2011","journal-title":"ISME J"},{"issue":"5","key":"10.1016\/j.radonc.2018.04.023_b0065","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"issue":"12","key":"10.1016\/j.radonc.2018.04.023_b0070","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"10.1016\/j.radonc.2018.04.023_b0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s15010-013-0564-2","article-title":"Fusobacterium species infections: clinical spectrum and outcomes at a district general hospital","volume":"42","author":"Pett","year":"2014","journal-title":"Infection"},{"key":"10.1016\/j.radonc.2018.04.023_b0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.mib.2014.11.013","article-title":"Fusobacterium nucleatum: a commensal-turned pathogen","volume":"23","author":"Han","year":"2015","journal-title":"Curr Opin Microbiol"},{"issue":"12","key":"10.1016\/j.radonc.2018.04.023_b0085","doi-asserted-by":"crossref","first-page":"E559","DOI":"10.1111\/1469-0691.12287","article-title":"Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: a prospective study","volume":"19","author":"Ye","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"10.1016\/j.radonc.2018.04.023_b0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/odi.12224","article-title":"Microbiota and their role in the pathogenesis of oral mucositis","volume":"21","author":"Vanhoecke","year":"2015","journal-title":"Oral Dis"},{"key":"10.1016\/j.radonc.2018.04.023_b0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ebiom.2017.02.002","article-title":"The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma","volume":"18","author":"Zhu","year":"2017","journal-title":"EBioMedicine"},{"issue":"12","key":"10.1016\/j.radonc.2018.04.023_b0100","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1128\/IAI.63.12.4584-4588.1995","article-title":"Intergeneric coaggregation of oral Treponema spp. with Fusobacterium spp. and intrageneric coaggregation among Fusobacterium spp","volume":"63","author":"Kolenbrander","year":"1995","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.radonc.2018.04.023_b0105","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.anaerobe.2011.09.003","article-title":"Synergy in biofilm formation between Fusobacterium nucleatum and Prevotella species","volume":"18","author":"Okuda","year":"2012","journal-title":"Anaerobe"},{"key":"10.1016\/j.radonc.2018.04.023_b0110","first-page":"629","article-title":"Intra- and inter-species interactions in microbial communities","volume":"5","author":"Comolli","year":"2014","journal-title":"Front Microbiol"},{"issue":"9","key":"10.1016\/j.radonc.2018.04.023_b0115","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1348-0421.2001.tb01298.x","article-title":"Coaggregation of Porphyromonas gingivalis and Prevotella intermedia","volume":"45","author":"Kamaguch","year":"2001","journal-title":"Microbiol Immunol"},{"issue":"3","key":"10.1016\/j.radonc.2018.04.023_b0120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jmii.2012.09.005","article-title":"Coaggregation between Prevotella oris and Porphyromonas gingivalis","volume":"47","author":"Sato","year":"2014","journal-title":"J Microbiol Immunol Infect"},{"issue":"3","key":"10.1016\/j.radonc.2018.04.023_b0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4103\/ccd.ccd_1181_16","article-title":"Necrotizing ulcerative gingivitis","volume":"8","author":"Malek","year":"2017","journal-title":"Contemp Clin Dent"},{"issue":"1","key":"10.1016\/j.radonc.2018.04.023_b0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4269\/ajtmh.1999.60.150","article-title":"Isolation of Fusobacterium necrophorum from cancrum oris (noma)","volume":"60","author":"Falkler","year":"1999","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.radonc.2018.04.023_b0135","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1601-0825.1999.tb00081.x","article-title":"Microbiological understandings and mysteries of noma (cancrum oris)","volume":"5","author":"Falkler","year":"1999","journal-title":"Oral Dis"},{"issue":"6","key":"10.1016\/j.radonc.2018.04.023_b0140","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1600-0757.1994.tb00031.x","article-title":"Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms","volume":"2000","author":"Murayama","year":"1994","journal-title":"Periodontol"},{"issue":"3","key":"10.1016\/j.radonc.2018.04.023_b0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1902\/jop.1986.57.3.141","article-title":"Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment","volume":"57","author":"Johnson","year":"1986","journal-title":"J Periodontol"},{"issue":"11","key":"10.1016\/j.radonc.2018.04.023_b0150","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1902\/jop.1995.66.11.990","article-title":"Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: clinical staging and predisposing factors","volume":"66","author":"Horning","year":"1995","journal-title":"J Periodontol"},{"issue":"10","key":"10.1016\/j.radonc.2018.04.023_b0155","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.radonc.2018.04.023_b0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol"},{"issue":"6","key":"10.1016\/j.radonc.2018.04.023_b0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/omi.12065","article-title":"The inflammophilic character of the periodontitis-associated microbiota","volume":"29","author":"Hajishengallis","year":"2014","journal-title":"Mol Oral Microbiol"},{"issue":"2","key":"10.1016\/j.radonc.2018.04.023_b0170","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0360-3016(01)01444-4","article-title":"Mucositis reduction by selective elimination of oral flora in irradiated cancers of the head and neck: a placebo-controlled double-blind randomized study","volume":"50","author":"Wijers","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.radonc.2018.04.023_b0175","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/sj.bjc.6600824","article-title":"Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial","volume":"88","author":"Stokman","year":"2003","journal-title":"Br J Cancer"},{"issue":"11","key":"10.1016\/j.radonc.2018.04.023_b0180","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s00520-013-1847-y","article-title":"Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients","volume":"21","author":"Nicolatou-Galitis","year":"2013","journal-title":"Support Care Cancer"},{"issue":"1","key":"10.1016\/j.radonc.2018.04.023_b0185","first-page":"1","article-title":"Oral mucositis prevention and management by therapeutic laser in head and neck cancers","volume":"5","author":"Fekrazad","year":"2014","journal-title":"J Lasers Med Sci Winter"},{"issue":"10","key":"10.1016\/j.radonc.2018.04.023_b0190","first-page":"1453","article-title":"MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy","volume":"120","author":"Lalla","year":"2014","journal-title":"Cancer-Am Cancer Soc"},{"key":"10.1016\/j.radonc.2018.04.023_b0195","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jbiotec.2016.10.010","article-title":"Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study","volume":"239","author":"Kudrimoti","year":"2016","journal-title":"J Biotechnol"},{"issue":"6","key":"10.1016\/j.radonc.2018.04.023_b0200","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/jre.12164","article-title":"Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss","volume":"49","author":"Maekawa","year":"2014","journal-title":"J Periodontal Res"},{"issue":"4","key":"10.1016\/j.radonc.2018.04.023_b0205","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1601-0825.2006.01291.x","article-title":"Anti-inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease","volume":"13","author":"Riccia","year":"2007","journal-title":"Oral Dis"},{"issue":"6","key":"10.1016\/j.radonc.2018.04.023_b0210","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ejca.2011.06.010","article-title":"Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapy-induced mucositis in patients with head and neck cancer: a randomized double-blind placebo-controlled study","volume":"48","author":"Sharma","year":"2012","journal-title":"Eur J Cancer"},{"issue":"6","key":"10.1016\/j.radonc.2018.04.023_b0215","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.2041-1014.2012.00663.x","article-title":"Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","volume":"27","author":"Hajishengallis","year":"2012","journal-title":"Mol Oral Microbiol"},{"issue":"5","key":"10.1016\/j.radonc.2018.04.023_b0220","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.chom.2015.10.009","article-title":"Individual members of the microbiota disproportionately modulate host innate immune responses","volume":"18","author":"Rolig","year":"2015","journal-title":"Cell Host Microbe"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018302147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018302147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T15:51:55Z","timestamp":1604245915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814018302147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0167814018302147"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2018.04.023","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2018.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}