{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:11:24Z","timestamp":1770959484714,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.radonc.2018.07.023","type":"journal-article","created":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:17:56Z","timestamp":1533341876000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["SPECT\/CT-guided elective nodal irradiation for head and neck cancer: Estimation of clinical benefits using NTCP models"],"prefix":"10.1016","volume":"130","author":[{"given":"Pieter D.","family":"de Veij Mestdagh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmy","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper","family":"Carbaat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Hamming-Vrieze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter V.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Jakob","family":"Sonke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrahim","family":"Al-Mamgani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2018.07.023_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejca.2017.05.035","article-title":"Elective unilateral nodal irradiation in head and neck squamous cell carcinoma: a paradigm shift","volume":"82","author":"Al-Mamgani","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.radonc.2018.07.023_b0010","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1016\/j.ejca.2015.08.023","article-title":"Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer","volume":"51","author":"Schilling","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.radonc.2018.07.023_b0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/hed.20062","article-title":"The sentinel node concept in head and neck cancer: solution for the controversies in the NO neck?","volume":"26","author":"Werner","year":"2004","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2018.07.023_b0020","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/sj.bjc.6601877","article-title":"Sentinel lymph-node biopsy in head and neck cancer","volume":"91","author":"H\u00f6ft","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2018.07.023_b0025","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1002\/lary.21131","article-title":"Reliability of sentinel node technique in the treatment of N0 supraglottic laryngeal cancer","volume":"120","author":"Lawson","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.radonc.2018.07.023_b0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hed.23297","article-title":"Tonsillar cancer: The Peter MacCallum experience with unilateral and bilateral irradiation","volume":"36","author":"Liu","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2018.07.023_b0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.radonc.2007.06.005","article-title":"Morbidity after ipsilateral radiotherapy for oropharyngeal cancer","volume":"85","author":"Jensen","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.radonc.2007.03.002","article-title":"Unilateral versus bilateral irradiation in squamous cell head and neck cancer in relation to patient-rated xerostomia and sticky saliva","volume":"85","author":"Jellema","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.radonc.2012.12.014","article-title":"A prospective evaluation of patient-reported quality-of-life after (chemo)radiation for oropharyngeal cancer: Which patients are at risk of significant quality-of-life deterioration?","volume":"106","author":"Al-Mamgani","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0055","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ctrv.2009.08.008","article-title":"Dysphagia in head and neck cancer","volume":"35","author":"Manikantan","year":"2009","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.radonc.2018.07.023_b0060","doi-asserted-by":"crossref","DOI":"10.1007\/s00405-018-5050-0","article-title":"SPECT\/CT-guided lymph drainage mapping for the planning of unilateral elective nodal irradiation in head and neck squamous cell carcinoma","author":"de Veij Mestdagh","year":"2018","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"10.1016\/j.radonc.2018.07.023_b0065","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2013.10.010","article-title":"Delineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines","volume":"110","author":"Gr\u00e9goire","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.radonc.2015.07.041","article-title":"CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines","volume":"117","author":"Brouwer","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.radonc.2012.03.004","article-title":"NTCP models for patient-rated xerostomia and sticky saliva after treatment with intensity modulated radiotherapy for head and neck cancer: The role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0080","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2009.07.1708","article-title":"Parotid gland function after radiotherapy: The combined Michigan and Utrecht experience","volume":"78","author":"Dijkema","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.radonc.2011.08.009","article-title":"Predictive modelling for swallowing dysfunction after primary (chemo)radiation: Results of a prospective observational study","volume":"105","author":"Christianen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0090","doi-asserted-by":"crossref","first-page":"e351","DOI":"10.1016\/j.ijrobp.2012.05.020","article-title":"A prospective cohort study on radiation-induced hypothyroidism: development of an NTCP model","volume":"84","author":"Boomsma","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0095","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ijrobp.2009.04.087","article-title":"NTCP modeling of subacute\/late laryngeal edema scored by fiberoptic examination","volume":"75","author":"Rancati","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2015.10.004","article-title":"The quest for evidence for proton therapy: model-based approach and precision medicine","volume":"95","author":"Widder","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2013.05.007","article-title":"Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach","volume":"107","author":"Langendijk","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0110","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7594","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement","volume":"350","author":"Collins","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.radonc.2018.07.023_b0115","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"Chaturvedi","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0120","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0360-3016(99)90269-9","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0125","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.ijrobp.2008.02.059","article-title":"Large cohort dose-volume response analysis of parotid gland function after radiotherapy: intensity-modulated versus conventional radiotherapy","volume":"72","author":"Dijkema","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0130","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ijrobp.2008.02.061","article-title":"Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx","volume":"72","author":"Teguh","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0135","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2007.07.009","article-title":"Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: A dose-effect relationship","volume":"85","author":"Levendag","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0140","doi-asserted-by":"crossref","first-page":"E93","DOI":"10.1016\/j.ijrobp.2010.12.067","article-title":"Chemo-Imrt of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates","volume":"81","author":"Eisbruch","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0145","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.radonc.2015.11.009","article-title":"Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach","volume":"118","author":"Christianen","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.radonc.2013.06.029","article-title":"Hypothyroidism after primary radiotherapy for head and neck squamous cell carcinoma: Normal tissue complication probability modeling with latent time correction","volume":"109","author":"R\u00f8njom","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.07.023_b0155","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ijrobp.2007.01.010","article-title":"Dosimetric predictors of laryngeal edema","volume":"68","author":"Sanguineti","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.07.023_b0160","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ijrobp.2004.05.050","article-title":"Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT?","volume":"60","author":"Eisbruch","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018334224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018334224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:06:40Z","timestamp":1759122400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814018334224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":32,"alternative-id":["S0167814018334224"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2018.07.023","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SPECT\/CT-guided elective nodal irradiation for head and neck cancer: Estimation of clinical benefits using NTCP models","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2018.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}