{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:44:46Z","timestamp":1789019086845,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.radonc.2018.08.024","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T12:30:28Z","timestamp":1537619428000},"page":"270-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Diabetes mellitus and radiation induced lung injury after thoracic stereotactic body radiotherapy"],"prefix":"10.1016","volume":"129","author":[{"given":"Noah S.","family":"Kalman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey D.","family":"Hugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca N.","family":"Mahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitai D.","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2018.08.024_b0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ijrobp.2012.03.041","article-title":"Clinical and dosimetric predictors of radiation pneumonitis in a large series of patients treated with stereotactic body radiation therapy to the lung","volume":"85","author":"Baker","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0010","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1016\/j.ijrobp.2012.01.018","article-title":"Dose\u2013volume metrics associated with radiation pneumonitis after stereotactic body radiation therapy for lung cancer","volume":"83","author":"Matsuo","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0015","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ijrobp.2010.08.056","article-title":"A dose\u2013volume analysis of radiation pneumonitis in non\u2013small cell lung cancer patients treated with stereotactic body radiation therapy","volume":"82","author":"Barriger","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0020","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/j.prro.2016.01.015","article-title":"Pulmonary dose-volume predictors of radiation pneumonitis following stereotactic body radiation therapy","volume":"6","author":"Harder","year":"2016","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2018.08.024_b0025","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1002\/cncr.29640","article-title":"Stereotactic body radiation therapy versus no treatment for early stage non-small cell lung cancer in medically inoperable elderly patients: a National Cancer Data Base analysis","volume":"121","author":"Nanda","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2018.08.024_b0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1200\/JCO.2016.69.0834","article-title":"Impact of increasing age on cause-specific mortality and morbidity in patients with stage I non-small-cell lung cancer: a competing risks analysis","volume":"35","author":"Eguchi","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2018.08.024_b0035","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/dc10-0666","article-title":"Diabetes and cancer: a consensus report","volume":"33","author":"Giovannucci","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.radonc.2018.08.024_b0040","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0360-3016(98)00460-X","article-title":"Diabetes mellitus: a predictor for late radiation morbidity","volume":"43","author":"Herold","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0045","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.clgc.2016.08.020","article-title":"Prostate cancer patients with unmanaged diabetes or receiving insulin experience inferior outcomes and toxicities after treatment with radiation therapy","volume":"15","author":"Zaorsky","year":"2017","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.radonc.2018.08.024_b0050","unstructured":"Zhou H, Cao K, Cao P, Jiang W. [Impact of diabetes mellitus on clinicopathological factors and relation with radiation pneumonitis in 332 patients with lung cancer]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013;38:138\u201341."},{"key":"10.1016\/j.radonc.2018.08.024_b0055","unstructured":"Song H, Yu JM. [Effect of diabetes mellitus on the development of radiation pneumonitis in patients with non-small cell lung cancer]. Zhonghua Zhong Liu Za Zhi 2009;31:45\u20137."},{"key":"10.1016\/j.radonc.2018.08.024_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2015.07.1576","article-title":"Effect of diabetes mellitus and selected medications on the development of radiation pneumonitis in patients with locally advanced non-small cell lung cancer [Abstract]","volume":"93","author":"Hsia","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0065","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4329\/wjr.v6.i9.708","article-title":"Radiation pneumonitis after stereotactic radiation therapy for lung cancer","volume":"6","author":"Yamashita","year":"2014","journal-title":"World J Radiol"},{"key":"10.1016\/j.radonc.2018.08.024_b0070","doi-asserted-by":"crossref","first-page":"S639","DOI":"10.1016\/j.ijrobp.2014.05.1894","article-title":"The effect of diabetes and antidiabetic drugs on outcomes after pulmonary SBRT [Abstract]","volume":"90","author":"Harder","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2015.07.017","article-title":"A new CT-based method to quantify radiation-induced lung damage in patients","volume":"117","author":"Ghobadi","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.08.024_b0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.radonc.2015.07.021","article-title":"Prediction of lung density changes after radiotherapy by cone beam computed tomography response markers and pre-treatment factors for non-small cell lung cancer patients","volume":"117","author":"Bernchou","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.08.024_b0085","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.radonc.2015.07.033","article-title":"CT characteristics allow identification of patient-specific susceptibility for radiation-induced lung damage","volume":"117","author":"Defraene","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.08.024_b0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejrad.2009.10.029","article-title":"Radiation injury of the lung after stereotactic body radiation therapy (SBRT) for lung cancer: a timeline and pattern of CT changes","volume":"79","author":"Linda","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.radonc.2018.08.024_b0095","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.ijrobp.2011.11.080","article-title":"Regional normal lung tissue density changes in patients treated with stereotactic body radiation therapy for lung tumors","volume":"84","author":"Diot","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0100","first-page":"13","article-title":"Clinical and radiologic toxicity after thoracic stereotactic body radiation therapy","volume":"1","author":"Mitra","year":"2014","journal-title":"J J Rad Oncol"},{"key":"10.1016\/j.radonc.2018.08.024_b0105","doi-asserted-by":"crossref","first-page":"e425","DOI":"10.1016\/j.cllc.2017.05.014","article-title":"Radiomics-based assessment of radiation-induced lung injury after stereotactic ablative radiotherapy","volume":"18","author":"Moran","year":"2017","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.radonc.2018.08.024_b0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lungcan.2009.09.006","article-title":"Early and late lung radiographic injury following stereotactic body radiation therapy (SBRT)","volume":"69","author":"Trovo","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.radonc.2018.08.024_b0115","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ijrobp.2010.07.025","article-title":"Lung density changes after stereotactic radiotherapy: a quantitative analysis in 50 patients","volume":"81","author":"Palma","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0120","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) Version 4.03. USA: National Institutes of Health, National Cancer Institute; 2010."},{"key":"10.1016\/j.radonc.2018.08.024_b0125","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jdiacomp.2015.12.018","article-title":"Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications","volume":"30","author":"Domingueti","year":"2016","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.radonc.2018.08.024_b0130","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ijrobp.2017.02.211","article-title":"Current status of targeted radioprotection and radiation injury mitigation and treatment agents: a critical review of the literature","volume":"98","author":"Kalman","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0135","doi-asserted-by":"crossref","first-page":"20140596","DOI":"10.1259\/bjr.20140596","article-title":"Patients with severe emphysema have a low risk of radiation pneumonitis following stereotactic body radiotherapy","volume":"88","author":"Ishijima","year":"2015","journal-title":"Br J Radiol"},{"key":"10.1016\/j.radonc.2018.08.024_b0140","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ijrobp.2006.05.008","article-title":"CT appearance of radiation injury of the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) for lung cancers: are patients with pulmonary emphysema also candidates for SBRT for lung cancers?","volume":"66","author":"Kimura","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.08.024_b0145","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1002\/cncr.26186","article-title":"Risk factors for radiation-induced hypothyroidism: a literature-based meta-analysis","volume":"117","author":"Vogelius","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2018.08.024_b0150","doi-asserted-by":"crossref","first-page":"e643","DOI":"10.1016\/j.prro.2015.07.003","article-title":"Angiotensin-converting enzyme inhibitors decrease the risk of radiation pneumonitis after stereotactic body radiation therapy","volume":"5","author":"Harder","year":"2015","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2018.08.024_b0155","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/bmb\/ldq044","article-title":"Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents","volume":"97","author":"Fritz","year":"2011","journal-title":"Br Med Bull"},{"key":"10.1016\/j.radonc.2018.08.024_b0160","first-page":"35","article-title":"The use of isodose levels to interpret radiation induced lung injury: a quantitative analysis of computed tomography changes","volume":"6","author":"Knoll","year":"2016","journal-title":"Quant Imaging Med Surg"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018334649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018334649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T17:47:31Z","timestamp":1542822451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814018334649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0167814018334649"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2018.08.024","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes mellitus and radiation induced lung injury after thoracic stereotactic body radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2018.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}