{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:53:11Z","timestamp":1768924391228,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004700","name":"Taipei Medical University Funding","doi-asserted-by":"publisher","award":["TMU105-AE1-B26"],"award-info":[{"award-number":["TMU105-AE1-B26"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thegreenjournal.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.radonc.2018.09.010","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T08:16:47Z","timestamp":1538209007000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Treatment outcomes for unresectable intrahepatic cholangiocarcinoma: Nationwide, population-based, cohort study based on propensity score matching with the Mahalanobis metric"],"prefix":"10.1016","volume":"129","author":[{"given":"Wei-Wen","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Kun","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Lun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Ming","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2018.09.010_b0005","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/modpathol.3800682","article-title":"Neoplasms of the liver","volume":"20","author":"Goodman","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1016\/j.radonc.2018.09.010_b0010","unstructured":"National Health Insurance Administration, Ministry of Health and Welfare, Taiwan, R.O.C. (2014). National Health Insurance Annual Report 2014-2015.; 2016."},{"key":"10.1016\/j.radonc.2018.09.010_b0015","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/01.sla.0000251366.62632.d3","article-title":"Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution","volume":"245","author":"DeOliveira","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2018.09.010_b0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer Statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2018.09.010_b0025","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1046\/j.1440-1746.1999.01983.x","article-title":"Peripheral cholangiocarcinoma (cholangiocellular carcinoma): clinical features, diagnosis and treatment","volume":"14","author":"Chen","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.radonc.2018.09.010_b0030","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/bjs.1800840717","article-title":"Hepatolithiasis associated with cholangiocarcinoma","volume":"84","author":"Su","year":"1997","journal-title":"Br J Surg"},{"key":"10.1016\/j.radonc.2018.09.010_b0035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s005340050096","article-title":"Intrahepatic cholangiocarcinoma in Taiwan","volume":"6","author":"Chen","year":"1999","journal-title":"J Hepato-biliary-Pancreatic Surg"},{"key":"10.1016\/j.radonc.2018.09.010_b0040","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/hep.24150","article-title":"Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and non-Hodgkin lymphoma: a cohort study of parous women in Taiwan","volume":"53","author":"Fwu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.radonc.2018.09.010_b0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-2007-1007302","article-title":"Recent advances in the management of cholangiocarcinomas","volume":"14","author":"Vauthey","year":"1994","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.radonc.2018.09.010_b0050","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/13651820500372533","article-title":"Hilar cholangiocarcinoma: diagnosis and staging","volume":"7","author":"Jarnagin","year":"2005","journal-title":"HPB"},{"key":"10.1016\/j.radonc.2018.09.010_b0055","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4251\/wjgo.v5.i7.171","article-title":"Chemotherapy for cholangiocarcinoma: An update","volume":"5","author":"Ramirez-Merino","year":"2013","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.radonc.2018.09.010_b0060","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00280-005-0095-3","article-title":"Phase II study of single-agent gemcitabine in patients with advanced biliary tract cancer","volume":"57","author":"Okusaka","year":"2006","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.radonc.2018.09.010_b0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2407-5-61","article-title":"Phase II trial of weekly 24-hour infusion of gemcitabine in patients with advanced gallbladder and biliary tract carcinoma","volume":"5","author":"von Delius","year":"2005","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2018.09.010_b0070","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/cncr.21591","article-title":"Capecitabine combined with gemcitabine (CapGem) as first-line treatment in patients with advanced\/metastatic biliary tract carcinoma","volume":"104","author":"Cho","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2018.09.010_b0075","unstructured":"NCCN Clinical practice guidelines in oncology; 2018."},{"key":"10.1016\/j.radonc.2018.09.010_b0080","article-title":"Association between proton pump inhibitors and the risk of hepatocellular carcinoma","author":"Shao","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.radonc.2018.09.010_b0085","doi-asserted-by":"crossref","first-page":"1700339","DOI":"10.1002\/advs.201700339","article-title":"Radiation-sensitive dendrimer-based drug delivery system","volume":"5","author":"Wu","year":"2018","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.radonc.2018.09.010_b0090","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/cam4.1479","article-title":"Adjuvant radiotherapy and chemotherapy improve survival in patients with pancreatic adenocarcinoma receiving surgery: adjuvant chemotherapy alone is insufficient in the era of intensity modulation radiation therapy","volume":"7","author":"Hsieh","year":"2018","journal-title":"Cancer Med"},{"key":"10.1016\/j.radonc.2018.09.010_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2018.03.007","article-title":"Efficacy of thoracic radiotherapy in patients with stage IIIB-IV epidermal growth factor receptor-mutant lung adenocarcinomas who received and responded to tyrosine kinase inhibitor treatment","author":"Yen","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.09.010_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2018.05.011","article-title":"Outcomes of adjuvant treatments for resectable intrahepatic cholangiocarcinoma: Chemotherapy alone, sequential chemoradiotherapy, or concurrent chemoradiotherapy","author":"Lin","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.09.010_b0105","article-title":"Treatment of advanced nasopharyngeal cancer using low- or high-dose concurrent chemoradiotherapy with intensity-modulated radiotherapy: A propensity score-matched, nationwide, population-based cohort study","author":"Chen","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.09.010_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2017.08.025","article-title":"Dose escalation intensity-modulated radiotherapy-based concurrent chemoradiotherapy is effective for advanced-stage thoracic esophageal squamous cell carcinoma","author":"Chang","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2018.09.010_b0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1278-3218(01)00144-5","article-title":"Conformal therapy of locally advanced cholangiocarcinoma of the main bile ducts","volume":"6","author":"Bouras","year":"2002","journal-title":"Cancer Radiotherapie"},{"key":"10.1016\/j.radonc.2018.09.010_b0120","first-page":"316","article-title":"Impact of pretreatment cholinesterase level on survival of inoperable intrahepatic or hepatic-hilar carcinomas treated with three-dimensional conformal radiotherapy","volume":"22","author":"Hamamoto","year":"2004","journal-title":"Radiation Med"},{"key":"10.1016\/j.radonc.2018.09.010_b0125","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0360-3016(94)90115-5","article-title":"The impact of radiation dose in combined external beam and intraluminal Ir-192 brachytherapy for bile duct cancer","volume":"28","author":"Alden","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.09.010_b0130","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.radonc.2018.09.010_b0135","article-title":"Curative-intent aggressive treatment improves survival in elderly patients with locally advanced head and neck squamous cell carcinoma and high comorbidity index","volume":"95","author":"Chen","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.radonc.2018.09.010_b0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4615-2009-2_5","article-title":"Goodness-of-fit and diagnostics for proportional hazards regression models","volume":"75","author":"Grambsch","year":"1995","journal-title":"Cancer Treat Res"},{"key":"10.1016\/j.radonc.2018.09.010_b0145","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B","article-title":"Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group","volume":"17","author":"D'Agostino","year":"1998","journal-title":"Stat Med"},{"key":"10.1016\/j.radonc.2018.09.010_b0150","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/1748-717X-8-292","article-title":"Outcomes of concurrent chemoradiotherapy versus chemotherapy alone for advanced-stage unresectable intrahepatic cholangiocarcinoma","volume":"8","author":"Kim","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2018.09.010_b0155","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00066-004-1315-1","article-title":"Chemoradiation may prolong survival of patients with non-bulky unresectable extrahepatic biliary carcinoma. A retrospective analysis","volume":"180","author":"Brunner","year":"2004","journal-title":"Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft [et al]."},{"key":"10.1016\/j.radonc.2018.09.010_b0160","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ijrobp.2005.07.977","article-title":"Chemoradiation and brachytherapy in biliary tract carcinoma: long-term results","volume":"64","author":"Deodato","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.09.010_b0165","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0360-3016(99)00487-3","article-title":"Combined modality treatment in unresectable extrahepatic biliary carcinoma","volume":"46","author":"Morganti","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.09.010_b0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/01.coc.0000156920.11091.12","article-title":"A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinoma","volume":"28","author":"Lin","year":"2005","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.radonc.2018.09.010_b0175","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/cncr.20265","article-title":"Radiotherapy combined with transarterial infusion chemotherapy and concurrent infusion of a vasoconstrictor agent for nonresectable advanced hepatic hilar duct carcinoma","volume":"100","author":"Matsumoto","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2018.09.010_b0180","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijrobp.2003.11.003","article-title":"Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome","volume":"59","author":"Milano","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.09.010_b0185","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0360-3016(95)02032-2","article-title":"A phase I study of combined radiation therapy with 5-fluorouracil and low dose folinic acid in patients with locally advanced pancreatic or biliary carcinoma","volume":"34","author":"Hsue","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2018.09.010_b0190","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12874-015-0049-3","article-title":"Propensity score interval matching: using bootstrap confidence intervals for accommodating estimation errors of propensity scores","volume":"15","author":"Pan","year":"2015","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.radonc.2018.09.010_b0195","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.3748\/wjg.14.3224","article-title":"Prognostic factors in patients with advanced cholangiocarcinoma: role of surgery, chemotherapy and body mass index","volume":"14","author":"Farhat","year":"2008","journal-title":"World J Gastroenterol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018334935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814018334935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T12:48:11Z","timestamp":1542804491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814018334935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0167814018334935"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2018.09.010","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment outcomes for unresectable intrahepatic cholangiocarcinoma: Nationwide, population-based, cohort study based on propensity score matching with the Mahalanobis metric","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2018.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}