{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:25:39Z","timestamp":1791869139797,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.radonc.2019.05.009","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T04:58:12Z","timestamp":1558933092000},"page":"52-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Inclusion of heart substructures in the optimization process of volumetric modulated arc therapy techniques may reduce the risk of heart disease in Hodgkin\u2019s lymphoma patients"],"prefix":"10.1016","volume":"138","author":[{"given":"Mario","family":"Levis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Riccardo","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fiandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bartoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwayne","family":"Vella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Ragona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Ricardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2019.05.009_b0005","doi-asserted-by":"crossref","first-page":"vi19","DOI":"10.1093\/annonc\/mdy080","article-title":"Hodgkin lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Eichenauer","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0010","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.ijrobp.2009.05.012","article-title":"Involved-node and involved-field volumetric modulated arc vs. fixed beam intensity modulated radiotherapy for female patients with early-stage supradiaphragmatic Hodgkin Lymphoma: a comparative planning study","volume":"75","author":"Weber","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0015","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1748-717X-9-94","article-title":"Dosimetric advantages of a \u201cbutterfly\u201d technique for intensity-modulated radiation therapy for young female patients with mediastinal Hodgkin\u2019s lymphoma","volume":"9","author":"Voong","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0020","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s00066-014-0719-9","article-title":"Novel radiotherapy techniques for involved-field and involved-node treatment of mediastinal Hodgkin lymphoma: when should they be considered and which questions remain open?","volume":"190","author":"Lohr","year":"2014","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.radonc.2019.05.009_b0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0360-3016(03)00073-7","article-title":"Radiation-induced second cancers: the impact of 3D-CRT and IMRT","volume":"56","author":"Hall","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0030","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1182\/blood-2002-02-0634","article-title":"Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long term risks and risk factors","volume":"100","author":"Ng","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.radonc.2019.05.009_b0035","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.prro.2012.12.006","article-title":"Changes in breast cancer risk associated with different volumes, doses, and techniques in female Hodgkin lymphoma patients treated with supra-diaphragmatic radiation therapy","volume":"3","author":"Filippi","year":"2013","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijrobp.2015.02.030","article-title":"Optimized volumetric modulated arc therapy versus 3D-CRT for early stage mediastinal Hodgkin lymphoma without axillary involvement: a comparison of second cancers and heart disease risk","volume":"92","author":"Filippi","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0045","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.ijrobp.2010.05.035","article-title":"Predicted risk of radiation induced cancers after involved field and involved node radiotherapy with or without intensity modulation for early-stage Hodgkin lymphoma in female patients","volume":"81","author":"Weber","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0050","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/annonc\/mdt156","article-title":"Estimated risk of cardiovascular disease and second cancers with modern highly conformal radiotherapy for early stage mediastinal Hodgkin lymphoma","volume":"24","author":"Maraldo","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijrobp.2015.01.013","article-title":"Minimizing late effects for patients with mediastinal Hodgkin lymphoma: deep inspiration breath-hold, IMRT, or both?","volume":"92","author":"Aznar","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijrobp.2017.09.039","article-title":"Intensity modulated radiation therapy and second cancer risk in adults","volume":"100","author":"Filippi","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0065","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/1748-717X-7-186","article-title":"Different IMRT solutions vs 3D-conformal radiotherapy in early stage Hodgkin lymphoma: dosimetric comparison and clinical considerations","volume":"7","author":"Fiandra","year":"2012","journal-title":"Radiat Oncol"},{"issue":"16","key":"10.1016\/j.radonc.2019.05.009_b0070","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1001\/jama.1993.03510160067031","article-title":"Factors affecting late mortality from heart disease after treatment of Hodgkin\u2019s disease","volume":"270","author":"Hancock","year":"1993","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.radonc.2019.05.009_b0075","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1182\/blood-2006-07-034405","article-title":"Late cardiotoxicity after treatment for Hodgkin lymphoma","volume":"109","author":"Aleman","year":"2007","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.radonc.2019.05.009_b0080","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1182\/blood-2010-06-291328","article-title":"Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation","volume":"117","author":"Galper","year":"2011","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.radonc.2019.05.009_b0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1200\/JCO.2015.63.4444","article-title":"Radiation dose-response relationship for risk of coronary heart disease in survivors of Hodgkin lymphoma","volume":"34","author":"van Nimwegen","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0090","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.radonc.2015.07.043","article-title":"Coronary stenosis risk analysis following Hodgkin lymphoma radiotherapy: a study based on patient specific artery segments dose calculation","volume":"117","author":"Moignier","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0095","doi-asserted-by":"crossref","first-page":"008","DOI":"10.1093\/jnci\/djv008","article-title":"Risk for valvular heart disease after treatment for Hodgkin lymphoma","volume":"107","author":"Cutter","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2019.05.009_b0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijrobp.2009.10.058","article-title":"Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer","volume":"79","author":"Feng","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0105","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.radonc.2018.04.014","article-title":"Plan optimization for mediastinal radiotherapy: estimation of coronary arteries motion with ECG-gated cardiac imaging and creation of compensatory expansion margins","volume":"127","author":"Levis","year":"2018","journal-title":"Radioth Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0110","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ijrobp.2014.01.041","article-title":"Involved-site image-guided intensity-modulated radiotherapy vs 3D conformal radiotherapy in supra-diaphragmatic early stage Hodgkin lymphoma","volume":"89","author":"Filippi","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0115","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1002\/cncr.28925","article-title":"Coronary artery disease detected by coronary computed tomography angiography in adult survivors of childhood Hodgkin lymphoma","volume":"120","author":"Mulrooney","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2019.05.009_b0120","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.ijrobp.2004.12.040","article-title":"Estimation of radiation-induced cancer from three-dimensional dose distributions: concept of organ equivalent dose","volume":"61","author":"Schneider","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1748-717X-9-58","article-title":"Radiation-induced second malignancies after involved-node radiotherapy with deep-insipiration breath-hold technique for early stage Hodgkin lymphoma: a dosimetric study","volume":"9","author":"Schneider","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0130","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s004110100106","article-title":"On the conversion of solid cancer excess relative risk into lifetime attributable risk","volume":"40","author":"Kellerer","year":"2001","journal-title":"Radiat Environ Biophys"},{"key":"10.1016\/j.radonc.2019.05.009_b0135","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"issue":"16","key":"10.1016\/j.radonc.2019.05.009_b0140","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1182\/blood-2016-09-740332","article-title":"Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines","volume":"129","author":"van Nimwegen","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.radonc.2019.05.009_b0145","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S2352-3026(15)00153-2","article-title":"Cardiovascular disease after treatment for Hodgkin\u2019s lymphoma: an analysis of nine collaborative EORTC-LYSA trials","volume":"2","author":"Maraldo","year":"2015","journal-title":"Lancet Hematol"},{"key":"10.1016\/j.radonc.2019.05.009_b0150","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.ijrobp.2017.03.026","article-title":"Late cardiac toxicity after mediastinal radiation therapy for Hodgkin lymphoma: contributions of coronary artery and whole heart dose-volume variables to risk prediction","volume":"98","author":"Hahn","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.05.009_b0155","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/0284186X.2016.1182209","article-title":"Radiation dose distribution in coronary arteries in breast cancer radiotherapy","volume":"55","author":"Nilsson","year":"2016","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2019.05.009_b0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijrobp.2012.09.001","article-title":"solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship","volume":"86","author":"Berrington de Gonzalez","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814019304086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814019304086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:07:23Z","timestamp":1759122443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814019304086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":32,"alternative-id":["S0167814019304086"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2019.05.009","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inclusion of heart substructures in the optimization process of volumetric modulated arc therapy techniques may reduce the risk of heart disease in Hodgkin\u2019s lymphoma patients","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2019.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}