{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:25:53Z","timestamp":1760955953648,"version":"3.44.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.radonc.2019.06.003","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T17:18:22Z","timestamp":1561483102000},"page":"80-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Low incidence of late failure and toxicity after spine stereotactic radiosurgery: Secondary analysis of phase I\/II trials with long-term follow-up"],"prefix":"10.1016","volume":"138","author":[{"given":"Matthew S.","family":"Ning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Deegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3703-8251","authenticated-orcid":false,"given":"Jennifer C.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavana V.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela K.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar M.","family":"Tannir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrang","family":"Amini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina M.","family":"Briere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin A.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio E.","family":"Tatsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence D.","family":"Rhines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-4577","authenticated-orcid":false,"given":"Amol J.","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2019.06.003_b0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3171\/2016.1.SPINE151166","article-title":"The use of spine stereotactic radiosurgery for oligometastatic disease","volume":"25","author":"Ho","year":"2016","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2018.07.2023","article-title":"Phase 1 study of spinal cord constraint relaxation with single session spine stereotactic radiosurgery in the primary management of patients with inoperable, previously unirradiated metastatic epidural spinal cord compression","author":"Ghia","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0015","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.ijrobp.2015.03.037","article-title":"Outcomes for spine stereotactic body radiation therapy and an analysis of predictors of local recurrence","volume":"92","author":"Bishop","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0020","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ijrobp.2014.07.037","article-title":"Incidence and predictive factors of pain flare after spine stereotactic body radiation therapy: secondary analysis of phase 1\/2 trials","volume":"90","author":"Pan","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0025","first-page":"191","article-title":"Prospective evaluation of target and spinal cord motion and dosimetric changes with respiration in spinal stereotactic body radiation therapy utilizing 4-D CT","volume":"4","author":"Wang","year":"2016","journal-title":"J Radiosurgery SBRT"},{"key":"10.1016\/j.radonc.2019.06.003_b0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3171\/2015.8.SPINE15844","article-title":"Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of phase I\/II trials","volume":"24","author":"Ghia","year":"2016","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0035","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ijrobp.2016.03.022","article-title":"Stereotactic body radiation therapy for spinal metastases in the postoperative setting: a secondary analysis of mature phase 1\u20132 trials","volume":"95","author":"Tao","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0040","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1089\/thy.2016.0046","article-title":"Spine stereotactic radiosurgery for patients with metastatic thyroid cancer: secondary analysis of phase I\/II trials","volume":"26","author":"Bernstein","year":"2016","journal-title":"Thyroid"},{"key":"10.1016\/j.radonc.2019.06.003_b0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3171\/SPI-07\/08\/151","article-title":"Phase I\/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure","volume":"7","author":"Chang","year":"2007","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0050","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1002\/cncr.27530","article-title":"Phase 1\/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases","volume":"118","author":"Garg","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2019.06.003_b0055","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3171\/2017.1.SPINE161045","article-title":"Spine stereotactic radiosurgery for metastatic sarcoma: patterns of failure and radiation treatment volume considerations","volume":"27","author":"Bishop","year":"2017","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0060","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1200\/JCO.2006.09.7469","article-title":"Stereotactic body radiation therapy in multiple organ sites","volume":"25","author":"Timmerman","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2019.06.003_b0065","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3171\/2010.9.SPINE091005","article-title":"Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient","volume":"14","author":"Sahgal","year":"2011","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0070","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3171\/2014.10.SPINE14252","article-title":"Stereotactic radiosurgery for spinal metastases with or without separation surgery","volume":"22","author":"Bate","year":"2015","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0075","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1097\/BRS.0b013e3181b8b6f5","article-title":"Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes?","volume":"34","author":"Gerszten","year":"2009","journal-title":"Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0080","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijrobp.2010.11.026","article-title":"Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline","volume":"79","author":"Lutz","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0085","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3171\/2017.2.SPINE16976","article-title":"Reirradiation spine stereotactic body radiation therapy for spinal metastases: systematic review","volume":"27","author":"Myrehaug","year":"2017","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0090","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/BRS.0b013e318223b9b6","article-title":"Clinical outcome of metastatic spinal cord compression treated with surgical excision\u202f\u00b1\u202fradiation versus radiation therapy alone: a systematic review of literature","volume":"37","author":"Kim","year":"2012","journal-title":"Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0095","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0140-6736(05)66954-1","article-title":"Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial","volume":"366","author":"Patchell","year":"2005","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.radonc.2019.06.003_b0100","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ijrobp.2015.05.035","article-title":"Five-year outcomes of high-dose single-fraction spinal stereotactic radiosurgery","volume":"93","author":"Moussazadeh","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0105","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ijrobp.2018.02.035","article-title":"Long-term outcomes after stereotactic radiosurgery for spine metastases: radiation dose-response for late toxicity","volume":"101","author":"Ling","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrclinonc.2009.188","article-title":"Stereotactic body radiation therapy: a novel treatment modality","volume":"7","author":"Lo","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.radonc.2019.06.003_b0115","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.ijrobp.2017.08.028","article-title":"Heterogeneity in treatment response of spine metastases to spine stereotactic radiosurgery within \u201cradiosensitive\u201d subtypes","volume":"99","author":"Bernard","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0120","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijrobp.2007.11.046","article-title":"High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions","volume":"71","author":"Yamada","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3171\/2012.11.SPINE12111","article-title":"Local disease control for spinal metastases following \u201cseparation surgery\u201d and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients","volume":"18","author":"Laufer","year":"2013","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrclinonc.2011.75","article-title":"The role of local therapy in the management of lung and liver oligometastases","volume":"8","author":"Lo","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.radonc.2019.06.003_b0135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.prro.2018.11.009","article-title":"Analysis of local control and pain control after spine stereotactic radiosurgery reveals inferior outcomes for hepatocellular carcinoma compared with other radioresistant histologies","volume":"9","author":"McGee","year":"2019","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2019.06.003_b0140","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ijrobp.2009.12.038","article-title":"Predictors of local control after single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases","volume":"79","author":"Greco","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3171\/2010.3.SPINE09639","article-title":"Local disease control after decompressive surgery and adjuvant high-dose single-fraction radiosurgery for spine metastases","volume":"13","author":"Moulding","year":"2010","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.radonc.2019.06.003_b0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ccr.2005.07.014","article-title":"Engaging the vascular component of the tumor response","volume":"8","author":"Fuks","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.radonc.2019.06.003_b0155","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ijrobp.2007.10.059","article-title":"Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy","volume":"70","author":"Park","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.003_b0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijrobp.2010.08.021","article-title":"Reirradiation human spinal cord tolerance for stereotactic body radiotherapy","volume":"82","author":"Sahgal","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814019329391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814019329391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:08:09Z","timestamp":1759122489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814019329391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":32,"alternative-id":["S0167814019329391"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2019.06.003","relation":{},"ISSN":["0167-8140"],"issn-type":[{"type":"print","value":"0167-8140"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low incidence of late failure and toxicity after spine stereotactic radiosurgery: Secondary analysis of phase I\/II trials with long-term follow-up","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2019.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}