{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:58:40Z","timestamp":1792403920719,"version":"4.4.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Trond Mohn Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.radonc.2019.06.028","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T04:46:44Z","timestamp":1562993204000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Optic nerve constraints for carbon ion RT at CNAO \u2013 Reporting and relating outcome to European and Japanese RBE"],"prefix":"10.1016","volume":"140","author":[{"given":"Jon Espen","family":"Dale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Molinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Vitolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vischioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bonora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Magro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge Egil Seime","family":"Pettersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mairani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Valvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Fossati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2019.06.028_b0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijrobp.2005.07.298","article-title":"Outcomes of visual acuity in carbon ion radiotherapy: analysis of dose-volume histograms and prognostic factors","volume":"64","author":"Hasegawa","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.028_b0010","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0360-3016(98)00544-6","article-title":"Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy","volume":"44","author":"Kanai","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.028_b0015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2307\/3579446","article-title":"Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy","volume":"147","author":"Kanai","year":"1997","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2019.06.028_b0020","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1088\/0031-9155\/45\/11\/314","article-title":"Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose","volume":"45","author":"Kramer","year":"2000","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2019.06.028_b0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s004110050055","article-title":"Computation of cell survival in heavy ion beams for therapy","volume":"36","author":"Scholz","year":"1997","journal-title":"Radiat Environ Biophys"},{"key":"10.1016\/j.radonc.2019.06.028_b0030","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/aa642b","article-title":"The FLUKA Monte Carlo code coupled with the NIRS approach for clinical dose calculations in carbon ion therapy","author":"Magro","year":"2017","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2019.06.028_b0035","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1088\/0031-9155\/57\/22\/7543","article-title":"Dose prescription in carbon ion radiotherapy: a planning study to compare NIRS and LEM approaches with a clinically-oriented strategy","volume":"57","author":"Fossati","year":"2012","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2019.06.028_b0040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.radonc.2016.05.031","article-title":"Dose prescription in carbon ion radiotherapy: how to compare two different RBE-weighted dose calculation systems","volume":"120","author":"Molinelli","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2019.06.028_b0045","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ijrobp.2012.01.038","article-title":"Mapping of RBE-weighted doses between HIMAC- and LEM-based treatment planning systems for carbon ion therapy","volume":"84","author":"Steinstrater","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.028_b0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejmp.2015.03.001","article-title":"The National Centre for Oncological Hadrontherapy (CNAO): status and perspectives","volume":"31","author":"Rossi","year":"2015","journal-title":"Phys Med"},{"key":"10.1016\/j.radonc.2019.06.028_b0055","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1118\/1.4928397","article-title":"Dosimetric commissioning and quality assurance of scanned ion beams at the Italian National Center for Oncological Hadrontherapy","volume":"42","author":"Mirandola","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2019.06.028_b0060","unstructured":"Common Terminology Criteria for Adverse Events v4.03. 2010, National Cancer Institute: NIH publication; no. 90-5410."},{"key":"10.1016\/j.radonc.2019.06.028_b0065","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.adro.2017.05.007","article-title":"Risk of carotid blowout after reirradiation with particle therapy","volume":"2","author":"Dale","year":"2017","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.radonc.2019.06.028_b0070","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.radonc.2015.11.023","article-title":"Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer","volume":"118","author":"Fukahori","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2019.06.028_b0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.radonc.2017.08.014","article-title":"Dose-volume histogram analysis of brainstem necrosis in head and neck tumors treated using carbon-ion radiotherapy","volume":"125","author":"Shirai","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2019.06.028_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141734","article-title":"Prediction of acute radiation mucositis using an oral mucosal dose surface model in carbon ion radiotherapy for head and neck tumors","volume":"10","author":"Musha","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.radonc.2019.06.028_b0085","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.radonc.2016.04.040","article-title":"Dosimetric analysis of upper gastrointestinal ulcer after carbon-ion radiotherapy for pancreatic cancer","volume":"120","author":"Shinoto","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2019.06.028_b0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.radonc.2009.08.041","article-title":"Dose-volume histogram and dose-surface histogram analysis for skin reactions to carbon ion radiotherapy for bone and soft tissue sarcoma","volume":"95","author":"Yanagi","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2019.06.028_b0095","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/S0167-8140(04)80022-7","article-title":"Treatment planning for carbon ion radiotherapy in Germany: review of clinical trials and treatment planning studies","volume":"73","author":"Jakel","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2019.06.028_b0100","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2006.12.059","article-title":"Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas","volume":"68","author":"Schulz-Ertner","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2019.06.028_b0105","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/1471-2407-10-606","article-title":"Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study","volume":"10","author":"Nikoghosyan","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2019.06.028_b0110","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.radonc.2018.05.001","article-title":"Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus","volume":"128","author":"Lambrecht","year":"2018","journal-title":"Radiother Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814019329688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814019329688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:09:32Z","timestamp":1759122572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814019329688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":22,"alternative-id":["S0167814019329688"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2019.06.028","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optic nerve constraints for carbon ion RT at CNAO \u2013 Reporting and relating outcome to European and Japanese RBE","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2019.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}