{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:19:07Z","timestamp":1789510747194,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003803","name":"University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.radonc.2020.06.016","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T15:57:48Z","timestamp":1592063868000},"page":"97-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Saliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-6310","authenticated-orcid":false,"given":"Xinmiao","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Y.K.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya Jane","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-8524","authenticated-orcid":false,"given":"Siling","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-3705","authenticated-orcid":false,"given":"Wei-fa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-0819","authenticated-orcid":false,"given":"Kenneth C.W.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-2854","authenticated-orcid":false,"given":"Dora L.W.","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-xiong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2020.06.016_b0005","unstructured":"Registry HKC. Top Ten Cancers in 2016: Hong Kong Cancer Registry; 2018 [http:\/\/www3.ha.org.hk\/cancereg\/topten.html]."},{"key":"10.1016\/j.radonc.2020.06.016_b0010","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/hed.20045","article-title":"Radiation-induced Xerostomia in patients with head and neck cancer: pathogenesis, impact on quality of life, and management","volume":"26","author":"Chambers","year":"2004","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2020.06.016_b0015","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ijrobp.2006.06.013","article-title":"Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial","volume":"66","author":"Pow","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.06.016_b0020","first-page":"593","article-title":"[Clinical analysis of xerostomia in patients with nasopharyngeal carcinoma after radiation therapy]","volume":"23","author":"Liu","year":"2004","journal-title":"Chinese J Cancer"},{"key":"10.1016\/j.radonc.2020.06.016_b0025","first-page":"214","article-title":"Xerostomia after radiotherapy and its effect on quality of life in head and neck cancer patients","volume":"15","author":"Kakoei","year":"2012","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.radonc.2020.06.016_b0030","first-page":"1039","article-title":"A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life","volume":"18","author":"Jensen","year":"2010","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2020.06.016_b0035","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.06.016_b0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11282-013-0151-3","article-title":"Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors","volume":"30","author":"Obinata","year":"2014","journal-title":"Oral Radiol"},{"key":"10.1016\/j.radonc.2020.06.016_b0045","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.oraloncology.2018.11.014","article-title":"Radiation therapy quality assurance in head and neck radiotherapy \u2013 Moving forward","volume":"88","author":"McDowell","year":"2019","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2020.06.016_b0050","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/cncr.20552","article-title":"Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: a prospective study on disease control and preservation of salivary function","volume":"101","author":"Kwong","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2020.06.016_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040636","article-title":"Effect of irradiation on cell transcriptome and proteome of rat submandibular salivary glands","volume":"7","author":"Stiubea-Cohen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.radonc.2020.06.016_b0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0360-3016(93)90143-J","article-title":"Major salivary gland function in patients with radiation-induced xerostomia: flow rates and sialochemistry","volume":"25","author":"Valdez","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.06.016_b0065","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/adj.12608","article-title":"Xerostomia, salivary characteristics and gland volumes following intensity-modulated radiotherapy for nasopharyngeal carcinoma: a two-year follow up","volume":"63","author":"Sim","year":"2018","journal-title":"Aust Dent J"},{"key":"10.1016\/j.radonc.2020.06.016_b0070","first-page":"925","article-title":"Assessment of radiation-induced xerostomia: validation of the Italian version of the xerostomia questionnaire in head and neck cancer patients","volume":"23","author":"Pellegrino","year":"2015","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2020.06.016_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152817","article-title":"Salivary anionic changes after radiotherapy for nasopharyngeal carcinoma: a 1-year prospective study","volume":"11","author":"Pow","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.radonc.2020.06.016_b0080","unstructured":"Hong Kong Cancer Registry HA. Nasopharyngeal Cancer in 2016 2016 [Available from: http:\/\/www3.ha.org.hk\/cancereg\/pdf\/factsheet\/2016\/npc_2016.pdf."},{"key":"10.1016\/j.radonc.2020.06.016_b0085","unstructured":"Government released the 2015 Hong Kong Smoking Prevalence. 2016."},{"key":"10.1016\/j.radonc.2020.06.016_b0090","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.oraloncology.2017.12.004","article-title":"Treatment outcomes of nasopharyngeal carcinoma in modern era after intensity modulated radiotherapy (IMRT) in Hong Kong: a report of 3328 patients (HKNPCSG 1301 study)","volume":"77","author":"Au","year":"2018","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2020.06.016_b0095","doi-asserted-by":"crossref","unstructured":"DePaola DP. Oral health: diet and other factors: the report of the British Nutrition Foundation's Task Force. Am J Clin Nutr 2000;71:1619.","DOI":"10.1093\/ajcn\/71.6.1619"},{"key":"10.1016\/j.radonc.2020.06.016_b0100","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/bjsm.31.1.28","article-title":"Sports drinks hazard to teeth","volume":"31","author":"Milosevic","year":"1997","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.radonc.2020.06.016_b0105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1515\/CCLM.2000.049","article-title":"Biochemical composition and electrolyte balance of \u201cunstimulated\u201d whole human saliva","volume":"38","author":"Rehak","year":"2000","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.radonc.2020.06.016_b0110","first-page":"3115-","article-title":"Use of human saliva as an electrolyte for corrosion testing of dental materials","volume":"76","author":"Ledvina","year":"1997","journal-title":"J Dental Res"},{"key":"10.1016\/j.radonc.2020.06.016_b0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5005\/jcdp-9-3-72","article-title":"Saliva composition and functions: a comprehensive review","volume":"9","author":"de Almeida","year":"2008","journal-title":"J Contemp Dental Pract"},{"key":"10.1016\/j.radonc.2020.06.016_b0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.archoralbio.2009.11.006","article-title":"Increased calcium and decreased magnesium and citrate concentrations of submandibular\/sublingual saliva in sialolithiasis","volume":"55","author":"Su","year":"2010","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.radonc.2020.06.016_b0125","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1067\/moe.2001.116814","article-title":"Saliva flow rate, amylase activity, and protein and electrolyte concentrations in saliva after acute alcohol consumption","volume":"92","author":"Enberg","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.radonc.2020.06.016_b0130","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ceca.2014.01.005","article-title":"Ca(2)(+)-dependent K(+) channels in exocrine salivary glands","volume":"55","author":"Catalan","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.radonc.2020.06.016_b0135","article-title":"Radioprotective effect of lidocaine on neurotransmitter agonist-induced secretion in irradiated salivary glands","volume":"8","author":"Su","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.radonc.2020.06.016_b0140","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1016\/j.ijrobp.2011.09.017","article-title":"Radioprotective effect of lidocaine on function and ultrastructure of salivary glands receiving fractionated radiation","volume":"82","author":"Hakim","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.06.016_b0145","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/026010600902000204","article-title":"Iodine in evolution of salivary glands and in oral health","volume":"20","author":"Venturi","year":"2009","journal-title":"Nutr Health"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781402030339X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781402030339X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:11:35Z","timestamp":1779811895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016781402030339X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":29,"alternative-id":["S016781402030339X"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2020.06.016","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Saliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2020.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}