{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:02:38Z","timestamp":1791946958036,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"am","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009142","name":"Cancer Care Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.radonc.2020.07.022","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T03:29:41Z","timestamp":1594783781000},"page":"33-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Dose-volume effects of breast cancer radiation therapy on the risk of second oesophageal cancer"],"prefix":"10.1016","volume":"151","author":[{"given":"Neige","family":"Journy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Schonfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8539-0148","authenticated-orcid":false,"given":"Michael","family":"Hauptmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Roberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Vaalavirta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Stovall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora E.","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-0468","authenticated-orcid":false,"given":"Rita E.","family":"Weathers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel S.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Berrington de Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay M.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2020.07.022_b0005","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000\u201314 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2020.07.022_b0010","first-page":"363","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.radonc.2020.07.022_b0015","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijrobp.2012.09.001","article-title":"Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship","volume":"86","author":"Berrington de Gonzalez","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ejcsup.2014.05.001","article-title":"Current knowledge and future research directions in treatment-related second primary malignancies","volume":"12","author":"Morton","year":"2014","journal-title":"EJC Suppl"},{"key":"10.1016\/j.radonc.2020.07.022_b0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.radonc.2014.10.004","article-title":"Risk of second non-breast cancer after radiotherapy for breast cancer: a systematic review and meta-analysis of 762,468 patients","volume":"114","author":"Grantzau","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0030","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1505949","article-title":"Second cancer risk up to 40 years after treatment for Hodgkin's lymphoma","volume":"373","author":"Schaapveld","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.radonc.2020.07.022_b0035","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1200\/JCO.2001.19.6.1610","article-title":"Lung cancer after Hodgkin's disease: a nested case-control study of the relation to treatment","volume":"19","author":"Swerdlow","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0040","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1200\/JCO.2011.38.8835","article-title":"Breast cancer risk after supradiaphragmatic radiotherapy for Hodgkin's lymphoma in England and Wales: a National Cohort Study","volume":"30","author":"Swerdlow","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0045","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1200\/JCO.2013.54.4601","article-title":"Breast cancer after chest radiation therapy for childhood cancer","volume":"32","author":"Moskowitz","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0050","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.radonc.2018.09.017","article-title":"Volume effects of radiotherapy on the risk of second primary cancers: a systematic review of clinical and epidemiological studies","volume":"131","author":"Journy","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0055","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ijrobp.2009.07.1754","article-title":"Use of normal tissue complication probability models in the clinic","volume":"76","author":"Marks","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.radonc.2020.07.022_b0060","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/j.ijrobp.2009.05.070","article-title":"Radiation dose-volume effects in the esophagus","volume":"76","author":"Werner-Wasik","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0065","doi-asserted-by":"crossref","unstructured":"Journy NM, Morton LM, Kleinerman RA, Bekelman JE, Berrington de Gonzalez A. Second primary cancers after intensity-modulated vs 3-dimensional conformal radiation therapy for prostate cancer. JAMA Oncol 2016;2:1368\u201370.","DOI":"10.1001\/jamaoncol.2016.1368"},{"key":"10.1016\/j.radonc.2020.07.022_b0070","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/annonc\/mds144","article-title":"Risk of treatment-related esophageal cancer among breast cancer survivors","volume":"23","author":"Morton","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1667\/RR3525.1","article-title":"Dose reconstruction for therapeutic and diagnostic radiation exposures: use in epidemiological studies","volume":"166","author":"Stovall","year":"2006","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2020.07.022_b0080","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ijrobp.2013.03.014","article-title":"Radiation dose to the esophagus from breast cancer radiation therapy, 1943\u20131996: an international population-based study of 414 patients","volume":"86","author":"Lamart","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0085","series-title":"Epicure Risk Regression and Person-Year Computation Software: Command Summary and User Guide","author":"Preston","year":"2015"},{"key":"10.1016\/j.radonc.2020.07.022_b0090","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2010.07.024","article-title":"Esophagus in-field: a new predictor for esophagitis","volume":"97","author":"Caglar","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/COC.0b013e3181a879e0","article-title":"Clinical and dosimetric risk factors of acute esophagitis in patients treated with 3-dimensional conformal radiotherapy for non-small-cell lung cancer","volume":"33","author":"Zhang","year":"2010","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0100","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ijrobp.2004.10.042","article-title":"\u201cAnatomically-correct\u201d dosimetric parameters may be better predictors for esophageal toxicity than are traditional CT-based metrics","volume":"62","author":"Kahn","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0105","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijrobp.2006.04.022","article-title":"Risk factors for acute esophagitis in non-small-cell lung cancer patients treated with concurrent chemotherapy and three-dimensional conformal radiotherapy","volume":"66","author":"Wei","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0110","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13014-016-0596-8","article-title":"Association of oesophageal radiation dose volume metrics, neutropenia and acute radiation oesophagitis in patients receiving chemoradiotherapy for non-small cell lung cancer","volume":"11","author":"Everitt","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1748-717X-9-54","article-title":"Risk factors of radiation-induced acute esophagitis in non-small cell lung cancer patients treated with concomitant chemoradiotherapy","volume":"9","author":"Zhang","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0120","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0360-3016(02)03937-8","article-title":"Predictors of radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with three-dimensional conformal radiotherapy","volume":"55","author":"Singh","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0125","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.3748\/wjg.v11.i17.2626","article-title":"Clinical and dosimetric factors of radiation-induced esophageal injury: radiation-induced esophageal toxicity","volume":"11","author":"Qiao","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.radonc.2020.07.022_b0130","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.radonc.2007.06.004","article-title":"Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters","volume":"85","author":"Jensen","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.radonc.2013.06.001","article-title":"Late dysphagia after IMRT for head and neck cancer and correlation with dose-volume parameters","volume":"107","author":"Mortensen","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0140","doi-asserted-by":"crossref","first-page":"e661","DOI":"10.1016\/j.ijrobp.2012.01.080","article-title":"Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery","volume":"83","author":"Cox","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0145","article-title":"Postmastectomy intensity modulation radiated therapy of chest wall and regional nodes: Retrospective analysis of the performance and complications up for 5 years","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.radonc.2020.07.022_b0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1748-717X-8-81","article-title":"Post mastectomy linac IMRT irradiation of chest wall and regional nodes: dosimetry data and acute toxicities","volume":"8","author":"Ma","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2020.07.022_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205770","article-title":"Dose to organs in the supraclavicular region when covering the Internal Mammary Nodes (IMNs) in breast cancer patients: A comparison of Volumetric Modulated Arc Therapy (VMAT) versus 3D and VMAT","volume":"13","author":"Dumane","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.radonc.2020.07.022_b0160","doi-asserted-by":"crossref","unstructured":"Duijm M, van der Voort van Zyp NC, van de Vaart P, Hoop EO, Mast ME, Hoogeman MS, et al. Predicting high-grade esophagus toxicity after treating central lung tumors with stereotactic radiotherapy using a Normal Tissue Complication Probability model. Int J Radiat Oncol Biol Phys 2019.","DOI":"10.1016\/j.ijrobp.2019.08.059"},{"key":"10.1016\/j.radonc.2020.07.022_b0165","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1038\/s41598-017-07586-x","article-title":"Voxel-based analysis unveils regional dose differences associated with radiation-induced morbidity in head and neck cancer patients","volume":"7","author":"Monti","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.radonc.2020.07.022_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijrobp.2006.01.027","article-title":"Intensity-modulated radiation therapy, protons, and the risk of second cancers","volume":"65","author":"Hall","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0175","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1088\/0952-4746\/34\/2\/325","article-title":"Radiotherapy-induced secondary cancer risk for breast cancer: 3D conformal therapy versus IMRT versus VMAT","volume":"34","author":"Lee","year":"2014","journal-title":"J Radiol Prot"},{"key":"10.1016\/j.radonc.2020.07.022_b0180","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijrobp.2017.09.039","article-title":"Intensity modulated radiation therapy and second cancer risk in adults","volume":"100","author":"Filippi","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2020.07.022_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1667\/RR0763.1","article-title":"Solid cancer incidence in atomic bomb survivors: 1958\u20131998","volume":"168","author":"Preston","year":"2007","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2020.07.022_b0190","unstructured":"UNSCEAR. Epidemiological studies of cancer risk due to low-dose-rate radiation from environmental sources. In: Sources, Effects and Risks of Ionizing Radiation, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2017 Report 2018."}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814020304151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814020304151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:10:55Z","timestamp":1759122655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814020304151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":38,"alternative-id":["S0167814020304151"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2020.07.022","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-volume effects of breast cancer radiation therapy on the risk of second oesophageal cancer","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2020.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}