{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:45:09Z","timestamp":1790271909381,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.radonc.2021.01.027","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T23:10:21Z","timestamp":1612480221000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Anorectal function and radiation dose to pelvic floor muscles after primary treatment for anal cancer"],"prefix":"10.1016","volume":"157","author":[{"given":"Camilla J.S.","family":"Kronborg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil G.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen-Lise G.","family":"Spindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2021.01.027_b0005","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/sj.bjc.6690567","article-title":"Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy","volume":"80","author":"Allal","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2021.01.027_b0010","doi-asserted-by":"crossref","first-page":"O230","DOI":"10.1111\/codi.13076","article-title":"Long-term anorectal, urinary and sexual dysfunction causing distress after radiotherapy for anal cancer: a Danish multicentre cross-sectional questionnaire study","volume":"17","author":"Sunesen","year":"2015","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.radonc.2021.01.027_b0015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.radonc.2013.05.037","article-title":"Faecal incontinence after chemoradiotherapy in anal cancer survivors: long-term results of a national cohort","volume":"108","author":"Bentzen","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0020","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000061309","article-title":"Impaired sphincter function and good quality of life in anal carcinoma patients after radiotherapy: a paradox?","volume":"37","author":"Vordermark","year":"2002","journal-title":"Front Radiat Ther Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0025","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S2468-1253(18)30264-4","article-title":"A core outcome set for clinical trials of chemoradiotherapy interventions for anal cancer (CORMAC): a patient and health-care professional consensus","volume":"3","author":"Fish","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.radonc.2021.01.027_b0030","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1080\/0284186X.2018.1503713","article-title":"Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review","volume":"57","author":"Pan","year":"2018","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0035","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0140-6736(15)60353-1","article-title":"Choice of a patient-reported outcome measure for patients with anal cancer for use in cancer clinical trials and routine clinical practice: a mixed methods approach","volume":"385","author":"Gilbert","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2021.01.027_b0040","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.radonc.2018.06.006","article-title":"Prospective evaluation of acute toxicity and patient reported outcomes in anal cancer and plan optimization","volume":"128","author":"Kronborg","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0045","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/SLA.0b013e31824f1c21","article-title":"Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer","volume":"255","author":"Emmertsen","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.radonc.2021.01.027_b0050","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ijrobp.2011.08.007","article-title":"Dose-effect relationships for individual pelvic floor muscles and anorectal complaints after prostate radiotherapy","volume":"83","author":"Smeenk","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2021.01.027_b0055","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.radonc.2014.10.002","article-title":"Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines","volume":"113","author":"Leon","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0060","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ijrobp.2008.08.070","article-title":"Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus panel contouring atlas","volume":"74","author":"Myerson","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2021.01.027_b0065","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1200\/JCO.2007.13.3439","article-title":"The prognostic significance of patient-reported outcomes in cancer clinical trials","volume":"26","author":"Gotay","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0070","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/jnci\/djr485","article-title":"Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival","volume":"103","author":"Quinten","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.radonc.2021.01.027_b0075","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/0284186X.2018.1438658","article-title":"Anal sphincter dysfunction in patients treated with primary radiotherapy for anal cancer: a study with the functional lumen imaging probe","volume":"57","author":"Haas","year":"2018","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0080","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.radonc.2017.11.018","article-title":"Phase I-III development of the EORTC QLQ-ANL27, a health-related quality of life questionnaire for anal cancer","volume":"126","author":"Sodergren","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0085","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00384-019-03342-x","article-title":"Quality of life in patients treated for anal carcinoma-a systematic literature review","volume":"34","author":"Sterner","year":"2019","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.radonc.2021.01.027_b0090","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00384-012-1593-5","article-title":"Impact of late anorectal dysfunction on quality of life after pelvic radiotherapy","volume":"28","author":"Krol","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.radonc.2021.01.027_b0095","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S1470-2045(07)70341-8","article-title":"Gastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patients","volume":"8","author":"Andreyev","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0100","series-title":"Anatomy, abdomen and pelvis, levator ani muscle","author":"Gowda","year":"2020"},{"key":"10.1016\/j.radonc.2021.01.027_b0105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.radonc.2018.04.012","article-title":"Abnormal neuronal response to rectal and anal stimuli in patients treated with primary radiotherapy for anal cancer","volume":"128","author":"Haas","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13014-018-1187-7","article-title":"Impact of VMAT-IMRT compared to 3D conformal radiotherapy on anal sphincter dose distribution in neoadjuvant chemoradiation of rectal cancer","volume":"13","author":"Dapper","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0115","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.radonc.2016.04.005","article-title":"Normal tissue complication probability (NTCP) models for late rectal bleeding, stool frequency and fecal incontinence after radiotherapy in prostate cancer patients","volume":"119","author":"Schaake","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13014-019-1262-8","article-title":"A systematic review of dose-volume predictors and constraints for late bowel toxicity following pelvic radiotherapy","volume":"14","author":"Jadon","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0125","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/0284186X.2016.1176247","article-title":"Defecation into clothing without forewarning and mean radiation dose to bowel and anal-sphincter among gynecological cancer survivors","volume":"55","author":"Lind","year":"2016","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0130","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ijrobp.2020.01.003","article-title":"Derivation of dose\/volume constraints for the anorectum from clinician- and patient-reported outcomes in the chhip trial of radiation therapy fractionation","volume":"106","author":"Wilkins","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2021.01.027_b0135","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.radonc.2012.03.002","article-title":"The dose-response of the anal sphincter region\u2013an analysis of data from the MRC RT01 trial","volume":"103","author":"Buettner","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.01.027_b0140","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.ijrobp.2009.03.078","article-title":"Radiation dose-volume effects in radiation-induced rectal injury","volume":"76","author":"Michalski","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2021.01.027_b0145","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ijrobp.2013.07.041","article-title":"Preliminary toxicity analysis of 3-dimensional conformal radiation therapy versus intensity modulated radiation therapy on the high-dose arm of the Radiation Therapy Oncology Group 0126 prostate cancer trial","volume":"87","author":"Michalski","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2021.01.027_b0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.radonc.2018.11.017","article-title":"Impact of radiotherapy on anorectal function in patients with rectal cancer following a watch and wait programme","volume":"132","author":"van der Sande","year":"2019","journal-title":"Radiother Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814021060242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814021060242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:15:04Z","timestamp":1759122904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814021060242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":30,"alternative-id":["S0167814021060242"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2021.01.027","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anorectal function and radiation dose to pelvic floor muscles after primary treatment for anal cancer","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2021.01.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}