{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:32:52Z","timestamp":1792096372217,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011851","name":"Kom op tegen kanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.radonc.2021.03.002","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T20:29:18Z","timestamp":1615408158000},"page":"268-275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Photobiomodulation therapy for the prevention of acute radiation dermatitis in head and neck cancer patients (DERMISHEAD trial)"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-1581","authenticated-orcid":false,"given":"Jolien","family":"Robijns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Lodewijckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"Van Bever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pannekoeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-1733","authenticated-orcid":false,"given":"Sandrine","family":"Censabella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lore","family":"Buss\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Colson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kaminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Broux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-7506","authenticated-orcid":false,"given":"Sofie","family":"Puts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Vanmechelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Timmermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"No\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bulens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke","family":"Govers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Mebis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2021.03.002_b0005","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int J Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0010","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41571-019-0227-z","article-title":"The changing therapeutic landscape of head and neck cancer","volume":"16","author":"Cramer","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.radonc.2021.03.002_b0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-0030-1255330","article-title":"Radiotherapy for head and neck cancer","volume":"24","author":"Yeh","year":"2010","journal-title":"Semin Plastic Surg"},{"key":"10.1016\/j.radonc.2021.03.002_b0020","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/ijd.13371","article-title":"Radiation dermatitis: an overview","volume":"56","author":"Hegedus","year":"2017","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.radonc.2021.03.002_b0025","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0167-8140(03)00166-X","article-title":"Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy","volume":"69","author":"Twardella","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2021.03.002_b0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaad.2005.08.054","article-title":"Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006","volume":"54","author":"Hymes","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.radonc.2021.03.002_b0035","unstructured":"The Royal College of Radiologists: The timely delivery of radical radiotherapy: standards and guidelines for the management of unscheduled treatment interruptions (3 ed). London, 2008."},{"key":"10.1016\/j.radonc.2021.03.002_b0040","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00129334-200209000-00007","article-title":"Wound care after radiation therapy","volume":"15","author":"Mendelsohn","year":"2002","journal-title":"Adv Skin Wound Care"},{"key":"10.1016\/j.radonc.2021.03.002_b0045","first-page":"2933","article-title":"Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group","volume":"21","author":"Wong","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0050","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S1460396900000133","article-title":"Intervention for acute radiotherapy induced skin reactions in cancer patients: the development of a clinical guideline recommended for use by the college of radiographers","volume":"2","author":"Glean","year":"2000","journal-title":"J Radiother Pract"},{"issue":"1","key":"10.1016\/j.radonc.2021.03.002_b0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radi.2011.10.040","article-title":"Radiotherapy skin care: A survey of practice in the UK","volume":"18","author":"Harris","year":"2012","journal-title":"Radiography"},{"key":"10.1016\/j.radonc.2021.03.002_b0060","first-page":"2793","article-title":"Low-level laser therapy\/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols","volume":"24","author":"Zecha","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0065","first-page":"2781","article-title":"Low level laser therapy\/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations","volume":"24","author":"Zecha","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0070","first-page":"332","article-title":"A narrative review on the use of photobiomodulation therapy for the prevention and management of acute radiodermatitis: proposed mechanisms, current clinical outcomes, and preliminary guidance for clinical studies","volume":"38","author":"Robijns","year":"2020","journal-title":"Photobiomodul Photomed Laser Surg"},{"key":"10.1016\/j.radonc.2021.03.002_b0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12957-018-1522-3","article-title":"Application of red light phototherapy in the treatment of radioactive dermatitis in patients with head and neck cancer","volume":"16","author":"Zhang","year":"2018","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.radonc.2021.03.002_b0080","first-page":"685","article-title":"The short-term effects of low-level laser therapy in the management of breast-cancer-related lymphedema","volume":"19","author":"Dirican","year":"2011","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0085","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/lsm.22804","article-title":"Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients (TRANSDERMIS trial)","volume":"50","author":"Robijns","year":"2018","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.radonc.2021.03.002_b0090","series-title":"Mitigation of cancer therapy side-effects with light","author":"Nair","year":"2016"},{"key":"10.1016\/j.radonc.2021.03.002_b0095","first-page":"1","article-title":"Photobiomodulation for the management of radiation dermatitis: the DERMIS trial, a pilot study of MLS\u00ae laser therapy in breast cancer patients","author":"Censabella","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0100","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/annonc\/mdr139","article-title":"Management of radiation dermatitis in patients receiving cetuximab and radiotherapy for locally advanced squamous cell carcinoma of the head and neck: proposals for a revised grading system and consensus management guidelines","volume":"22","author":"Bernier","year":"2011","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2021.03.002_b0105","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.12968\/bjon.1999.8.18.6490","article-title":"Radiation-induced skin reactions. 2: Development of a measurement tool","volume":"8","author":"Noble-Adams","year":"1999","journal-title":"Br J Nurs"},{"key":"10.1016\/j.radonc.2021.03.002_b0110","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.12968\/bjon.1999.8.19.1305","article-title":"Radiation-induced skin reactions. 3: Evaluating the RISRAS","volume":"8","author":"Noble-Adams","year":"1999","journal-title":"Br J Nurs"},{"key":"10.1016\/j.radonc.2021.03.002_b0115","doi-asserted-by":"crossref","unstructured":"Chren MM. The Skindex instruments to measure the effects of skin disease on quality of life. Dermatol Clin 2012;30:231-6, xiii. 10.1016\/j.det.2011.11.003.","DOI":"10.1016\/j.det.2011.11.003"},{"key":"10.1016\/j.radonc.2021.03.002_b0120","first-page":"1787","article-title":"Preemptive treatment with Xonrid(R), a medical device to reduce radiation induced dermatitis in head and neck cancer patients receiving curative treatment: a pilot study","volume":"25","author":"Iacovelli","year":"2017","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2217\/fon-2017-0359","article-title":"Prevention and treatment of radiation-induced acute dermatitis in head and neck cancer patients: a systematic review","volume":"14","author":"Iacovelli","year":"2018","journal-title":"Future Oncol"},{"key":"10.1016\/j.radonc.2021.03.002_b0130","doi-asserted-by":"crossref","DOI":"10.1002\/lsm.22804","article-title":"Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients (TRANSDERMIS trial)","author":"Robijns","year":"2018","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.radonc.2021.03.002_b0135","first-page":"1245","article-title":"Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients","volume":"27","author":"Robijns","year":"2019","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.radonc.2021.03.002_b0140","article-title":"Feasibility of photobiomodulation therapy for the prevention of radiodermatitis: a single-institution pilot study","author":"Park","year":"2019","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.radonc.2021.03.002_b0145","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ijrobp.2017.07.019","article-title":"Multicenter randomized double-blind, placebo-controlled trial GORTEC (Groupe Oncologie Radiotherapie Tete et Cou) 2009\u201301 evaluating the effect of the regenerating agent on radiodermatitis of head and neck cancer patients","volume":"99","author":"Tao","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2021.03.002_b0150","article-title":"Topical betamethasone valerate as a prophylactic agent to prevent acute radiation dermatitis in head and neck malignancies: a randomized, open-label, phase 3 trial","author":"Menon","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2021.03.002_b0155","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.semradonc.2017.08.008","article-title":"Head and neck cancer survivorship: learning the needs","volume":"28","author":"Ringash","year":"2018","journal-title":"Meeting the Needs. Semin Radiat Oncol."},{"key":"10.1016\/j.radonc.2021.03.002_b0160","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.clinimag.2020.06.047","article-title":"Adherence to pretreatment and intratreatment imaging of head and neck squamous cell carcinoma patients undergoing (chemo) radiotherapy in a research setting","volume":"69","author":"Martens","year":"2021","journal-title":"Clin Imaging"},{"key":"10.1016\/j.radonc.2021.03.002_b0165","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/lary.27676","article-title":"Disparities in adherence to head and neck cancer follow-up guidelines","volume":"129","author":"Perlow","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.radonc.2021.03.002_b0170","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1002\/hed.25936","article-title":"Adherence with National Comprehensive Cancer Network posttreatment surveillance guidelines in patients with head and neck cancer","volume":"41","author":"Tam","year":"2019","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2021.03.002_b0175","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1002\/hed.25950","article-title":"Evaluation of oncologic outcomes in head and neck cancer patients \u226580 years old based on adherence to NCCN guideline for postoperative adjuvant treatment","volume":"41","author":"Roden","year":"2019","journal-title":"Head Neck"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781402106117X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016781402106117X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:17:03Z","timestamp":1759123023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016781402106117X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":35,"alternative-id":["S016781402106117X"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2021.03.002","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photobiomodulation therapy for the prevention of acute radiation dermatitis in head and neck cancer patients (DERMISHEAD trial)","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2021.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}