{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:05:52Z","timestamp":1774127152169,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.radonc.2022.01.013","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T11:18:35Z","timestamp":1642677515000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["The dosimetric and clinical advantages of the GTV-CTV-PTV margins reduction by 6\u00a0mm in head and neck squamous cell carcinoma: Significant acute and late toxicity reduction"],"prefix":"10.1016","volume":"168","author":[{"given":"Abrahim","family":"Al-Mamgani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Kessels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Navran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper","family":"Carbaat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem H.","family":"Schreuder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Jakob","family":"Sonke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrie A.M.","family":"Marijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2022.01.013_b0005","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1056\/NEJMra0707975","article-title":"Recent advances in head and neck cancer","volume":"359","author":"Haddad","year":"2008","journal-title":"N Eng J Med"},{"key":"10.1016\/j.radonc.2022.01.013_b0010","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.7785\/tcrt.2012.500305","article-title":"Toxicity and outcome of intensity-modulated radiotherapy versus 3-dimensional conformal radiotherapy for oropharyngeal cancer: a matched-pair analysis","volume":"12","author":"Al-Mamgani","year":"2013","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.radonc.2022.01.013_b0020","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.radonc.2015.11.009","article-title":"Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: clinical validation according to the model-based approach","volume":"118","author":"Christianen","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0025","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.ijrobp.2011.05.019","article-title":"Stereotactic body radiotherapy: a promising treatment option for the boost of oropharyngeal cancers not suitable for brachytherapy: a single-institutional experience","volume":"82","author":"Al-Mamgani","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.013_b0030","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1080\/0284186X.2019.1654129","article-title":"NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy","volume":"58","author":"Hansen","year":"2019","journal-title":"Acta Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.radonc.2016.04.038","article-title":"The price of robustness; impact of worst-case optimization on organ-at-risk dose and complication probability in intensity-modulated proton therapy for oropharyngeal cancer patients","volume":"120","author":"van de Water","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0040","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.oraloncology.2013.12.019","article-title":"Epidemiology of HPV-associated oropharyngeal cancer","volume":"50","author":"Pytynia","year":"2014","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.oraloncology.2016.07.008","article-title":"Transoral robotic surgery: the radiation oncologist's perspective","volume":"60","author":"Ward","year":"2016","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.radonc.2020.03.012","article-title":"SPECT\/CT-guided elective nodal irradiation for head and neck cancer is oncologically safe and less toxic: a potentially practice-changing approach","volume":"147","author":"de Veij Mestdagh","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0055","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1002\/hed.23532","article-title":"Long-term experience with reduced planning target volume margins and intensity modulated radiotherapy with daily image-guidance for head and neck cancer","volume":"36","author":"Chen","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2022.01.013_b0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.radonc.2018.06.032","article-title":"The impact of margin reduction on outcome and toxicity in head and neck cancer patients treated with image-guided volumetric modulated arc therapy (VMAT)","volume":"130","author":"Navran","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2017.11.024","article-title":"Local recurrences after curative IMRT for HNSCC: effect of different GTV to high-dose CTV margins","volume":"126","author":"Zukauskaite","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0070","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.radonc.2021.07.016","article-title":"Reduction of GTV to high-risk CTV radiation margin in head and neck squamous cell carcinoma significantly reduced acute and late radiation-related toxicity with comparable outcomes","volume":"162","author":"Al-Mamgani","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.radonc.2009.12.017","article-title":"First clinical experience with a multiple region of interest registration and correction method in radiotherapy of head-and-neck cancer patients","volume":"94","author":"van Beek","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0080","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.radonc.2009.12.016","article-title":"Correction strategies to manage deformations in head-and-neck radiotherapy","volume":"94","author":"van Kranen","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tipsro.2019.11.001","article-title":"Protocolised way to cope with anatomical changes in head & neck cancer during the course of radiotherapy","volume":"16","author":"van Beek","year":"2019","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0090","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.radonc.2022.01.013_b0095","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2011.09.004","article-title":"Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands","volume":"83","author":"Little","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.013_b0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.radonc.2011.08.009","article-title":"Predictive modelling for swallowing dysfunction after primary (chemo)radiation: results of a prospective observational study","volume":"105","author":"Christianen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0105","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ijrobp.2004.05.050","article-title":"Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT?","volume":"60","author":"Eisbruch","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.013_b0110","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ijrobp.2009.02.017","article-title":"Dosimetric factors associated with long-term dysphagia after definitive radiotherapy for squamous cell carcinoma of the head and neck","volume":"76","author":"Caudell","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.013_b0115","doi-asserted-by":"crossref","DOI":"10.1186\/1748-717X-4-52","article-title":"Clinical-dosimetric analysis of measures of dysphagia including gastrostomy-tube dependence among head and neck cancer patients treated definitively by intensity-modulated radiotherapy with concurrent chemotherapy","volume":"4","author":"Li","year":"2009","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0120","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.radonc.2013.06.001","article-title":"Late dysphagia after IMRT for head and neck cancer and correlation with dose-volume parameters","volume":"107","author":"Mortensen","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00455-013-9452-2","article-title":"Systematic review of dose\u2013volume correlates for structures related to late swallowing disturbances after radiotherapy for head and neck cancer","volume":"28","author":"Duprez","year":"2013","journal-title":"Dysphagia"},{"key":"10.1016\/j.radonc.2022.01.013_b0130","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-016-2813-0","article-title":"DARS: a phase III randomised multicentre study of dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) versus standard intensity- modulated radiotherapy (S-IMRT) in head and neck cancer","volume":"16","author":"Petkar","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2022.01.013_b0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hed.1037","article-title":"Effects of xerostomia on perception and performance of swallow function","volume":"23","author":"Logemann","year":"2001","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2022.01.013_b0140","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ijrobp.2008.02.061","article-title":"Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx","volume":"72","author":"Teguh","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.013_b0145","doi-asserted-by":"crossref","first-page":"354","DOI":"10.14338\/IJPT-20-00089.1","article-title":"National protocol for model-based selection for proton therapy in head and neck cancer","volume":"8","author":"Langendijk","year":"2021","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.radonc.2022.01.013_b0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.radonc.2020.07.056","article-title":"First experience with model-based selection of head and neck cancer patients for proton therapy","volume":"151","author":"Tambas","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0155","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ijrobp.2010.09.038","article-title":"Evaluation of microscopic disease in oral tongue cancer using whole-mount histopathologic techniques: implications for the management of head-andneck cancers","volume":"82","author":"Campbell","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.013_b0160","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ijrobp.2005.08.020","article-title":"Determining optimal clinical target volume margins in head-and-neck cancer based on microscopic extracapsular extension of metastatic neck nodes","volume":"64","author":"Apisarnthanarax","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.013_b0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.radonc.2017.09.019","article-title":"Consequences of introducing geometric GTV to CTV margin expansion in DAHANCA contouring guidelines for head and neck radiotherapy","volume":"126","author":"Hansen","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.013_b0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.radonc.2017.10.016","volume":"126","author":"Gr\u00e9goire","year":"2018","journal-title":"Radiother Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022000172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022000172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:19:38Z","timestamp":1759123178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814022000172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":34,"alternative-id":["S0167814022000172"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2022.01.013","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dosimetric and clinical advantages of the GTV-CTV-PTV margins reduction by 6\u00a0mm in head and neck squamous cell carcinoma: Significant acute and late toxicity reduction","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2022.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}