{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:49:20Z","timestamp":1792813760862,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108026"],"award-info":[{"award-number":["81820108026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925031"],"award-info":[{"award-number":["81925031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202007030001"],"award-info":[{"award-number":["202007030001"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["81801229"],"award-info":[{"award-number":["81801229"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["82003389"],"award-info":[{"award-number":["82003389"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.radonc.2022.01.033","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T21:23:10Z","timestamp":1643750590000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["A novel nomogram to predict overall survival in head and neck cancer survivors with radiation-induced brain necrosis"],"prefix":"10.1016","volume":"168","author":[{"given":"Dong","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Tong","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongteng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2022.01.033_b0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2022.01.033_b0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s11912-006-0049-x","article-title":"How to reduce radiation-related toxicity in patients with cancer of the head and neck","volume":"8","author":"Garden","year":"2006","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.radonc.2022.01.033_b0015","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1095956","article-title":"Medicine. Modulation of radiation injury","volume":"304","author":"Coleman","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.radonc.2022.01.033_b0020","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/1097-0142(19880415)61:8<1535::AID-CNCR2820610809>3.0.CO;2-E","article-title":"Clinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma","volume":"61","author":"Lee","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.radonc.2022.01.033_b0025","first-page":"45","article-title":"Radiation injury of the brain","volume":"12","author":"Valk","year":"1991","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"10.1016\/j.radonc.2022.01.033_b0030","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/01.nrl.0000080951.78533.c4","article-title":"Cerebral radiation necrosis","volume":"9","author":"Giglio","year":"2003","journal-title":"Neurologist"},{"key":"10.1016\/j.radonc.2022.01.033_b0035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.14338\/IJPT-20-00014.1","article-title":"Temporal lobe necrosis in head and neck cancer patients after proton therapy to the skull base","volume":"6","author":"Kitpanit","year":"2020","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.radonc.2022.01.033_b0040","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.ijrobp.2010.11.070","article-title":"Clinical outcomes of 174 nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis","volume":"82","author":"Lam","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.033_b0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12943-019-0950-1","article-title":"Bevacizumab treatment for radiation brain necrosis: mechanism, efficacy and issues","volume":"18","author":"Zhuang","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.radonc.2022.01.033_b0050","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1200\/JCO.2007.12.9791","article-title":"How to build and interpret a nomogram for cancer prognosis","volume":"26","author":"Iasonos","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.radonc.2018.11.008","article-title":"A nomogram for the prediction of cerebrovascular disease among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma","volume":"132","author":"Cai","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0060","doi-asserted-by":"crossref","first-page":"e1392","DOI":"10.1212\/WNL.0000000000010190","article-title":"A nomogram to predict symptomatic epilepsy in patients with radiation-induced brain necrosis","volume":"95","author":"Huang","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.radonc.2022.01.033_b0065","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ijrobp.2017.11.023","article-title":"Clinical variables for prediction of the therapeutic effects of bevacizumab monotherapy in nasopharyngeal carcinoma patients with radiation-induced brain necrosis","volume":"100","author":"Li","year":"2018","journal-title":"int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.01.033_b0070","doi-asserted-by":"crossref","unstructured":"Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. Bmj. 2015;350:g7594. https:\/\/doi.org\/10.1136\/bmj.g7594.","DOI":"10.1136\/bmj.g7594"},{"key":"10.1016\/j.radonc.2022.01.033_b0075","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neurad.2013.07.005","article-title":"Neurological imaging of brain damages after radiotherapy and\/or chimiotherapy","volume":"41","author":"Martino","year":"2014","journal-title":"J Neuroradiol"},{"key":"10.1016\/j.radonc.2022.01.033_b0080","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.oraloncology.2017.12.004","article-title":"Treatment outcomes of nasopharyngeal carcinoma in modern era after intensity modulated radiotherapy (IMRT) in Hong Kong: A report of 3328 patients (HKNPCSG 1301 study)","volume":"77","author":"Au","year":"2018","journal-title":"Oral Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0085","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3","article-title":"The lasso method for variable selection in the Cox model","volume":"16","author":"Tibshirani","year":"1997","journal-title":"Stat Med"},{"key":"10.1016\/j.radonc.2022.01.033_b0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat Med"},{"key":"10.1016\/j.radonc.2022.01.033_b0095","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.eururo.2018.08.038","article-title":"Reporting and interpreting decision curve analysis: a guide for investigators","volume":"74","author":"Van Calster","year":"2018","journal-title":"Eur Urol"},{"key":"10.1016\/j.radonc.2022.01.033_b0100","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","article-title":"X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization","volume":"10","author":"Camp","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.radonc.2022.01.033_b0105","doi-asserted-by":"crossref","DOI":"10.1186\/1748-717X-8-17","article-title":"Analysis of dosimetric factors associated with temporal lobe necrosis (TLN) in patients with nasopharyngeal carcinoma (NPC) after intensity modulated radiotherapy","volume":"8","author":"Su","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0110","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13014-020-01560-0","article-title":"Radiation induced temporal lobe necrosis in nasopharyngeal cancer patients after radical external beam radiotherapy","volume":"15","author":"Wu","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0115","article-title":"Temporal lobe necrosis following radiotherapy in nasopharyngeal carcinoma: new insight into the management","volume":"10","author":"Zhou","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0120","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1748-717X-6-128","article-title":"Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management","volume":"6","author":"Chen","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0125","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc.2016.25","article-title":"Targeting metastasis","volume":"16","author":"Steeg","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2022.01.033_b0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41568-019-0222-9","article-title":"How the ageing microenvironment influences tumour progression","volume":"20","author":"Fane","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2022.01.033_b0135","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jcma.2017.01.006","article-title":"Risk factors for recurrent pneumonia in post-irradiated patients with nasopharyngeal carcinoma","volume":"80","author":"Wang","year":"2017","journal-title":"J Chin Med Assoc"},{"key":"10.1016\/j.radonc.2022.01.033_b0140","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1002\/hed.25923","article-title":"Swallowing-related outcomes associated with late lower cranial neuropathy in long-term oropharyngeal cancer survivors: cross-sectional survey analysis","volume":"41","author":"Aggarwal","year":"2019","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2022.01.033_b0145","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/hed.23827","article-title":"Incidence of late-onset pneumonia in patients after treatment with radiotherapy for nasopharyngeal carcinoma: A nationwide population-based study","volume":"37","author":"Yen","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.radonc.2022.01.033_b0150","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1148\/radiol.09090428","article-title":"Evolution of radiation-induced brain injury: MR imaging-based study","volume":"254","author":"Wang","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.radonc.2022.01.033_b0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","article-title":"Global and regional burden of stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010","volume":"383","author":"Feigin","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.radonc.2022.01.033_b0160","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","article-title":"Prevalence, incidence, and mortality of stroke in China: Results from a nationwide population-based survey of 480 687 adults","volume":"135","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.radonc.2022.01.033_b0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1024\/0301-1526\/a000403","article-title":"Carotid artery disease after head and neck radiotherapy","volume":"44","author":"Thalhammer","year":"2015","journal-title":"Vasa"},{"key":"10.1016\/j.radonc.2022.01.033_b0170","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2019.4669","article-title":"Cancer-associated stroke: Pathophysiology, detection and management (Review)","author":"Dardiotis","year":"2019","journal-title":"Int J Oncol"},{"key":"10.1016\/j.radonc.2022.01.033_b0175","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jvs.2019.11.034","article-title":"Surgical repair of radiation-induced carotid stenosis","volume":"72","author":"Renard","year":"2020","journal-title":"J Vasc Surg"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022000603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022000603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:20:34Z","timestamp":1759123234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814022000603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":35,"alternative-id":["S0167814022000603"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2022.01.033","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel nomogram to predict overall survival in head and neck cancer survivors with radiation-induced brain necrosis","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2022.01.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}