{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:10:37Z","timestamp":1791166237129,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.radonc.2022.09.015","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T21:57:38Z","timestamp":1664229458000},"page":"92-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Online adaptive radiotherapy of anal cancer: Normal tissue sparing, target propagation methods, and first clinical experience"],"prefix":"10.1016","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-7333","authenticated-orcid":false,"given":"Lina M.","family":"\u00c5str\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-1421","authenticated-orcid":false,"given":"Claus P.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Smedegaard","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-7777","authenticated-orcid":false,"given":"Patrik","family":"Sibolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-2086","authenticated-orcid":false,"given":"Eva","family":"Serup-Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2022.09.015_b0005","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1200\/JCO.1997.15.5.2040","article-title":"Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastro","volume":"15","author":"Bartelink","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0010","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1200\/JCO.1996.14.9.2527","article-title":"Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study","volume":"14","author":"Flam","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0015","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/sj.bjc.6605605","article-title":"Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I)","volume":"102","author":"Northover","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.radonc.2022.09.015_b0020","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1200\/JCO.2011.35.4837","article-title":"Induction chemotherapy and dose intensification of the radiation boost in locally advanced anal canal carcinoma: final analysis of the randomized UNICANCER ACCORD 03 trial","volume":"30","author":"Peiffert","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0025","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S1470-2045(13)70086-X","article-title":"Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): A randomised, phase 3, open-label, 2\u00d72 factorial trial","volume":"14","author":"James","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0030","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1001\/jama.299.16.1914","article-title":"Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial","volume":"299","author":"Ajani","year":"2008","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.radonc.2022.09.015_b0035","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.radonc.2014.04.013","article-title":"Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"111","author":"Glynne-Jones","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0040","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.annonc.2021.06.015","article-title":"Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\u2606","volume":"32","author":"Rao","year":"2021","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0045","doi-asserted-by":"crossref","unstructured":"Gr\u00e9goire V, Mackie T, De Neve W, Gospodarowicz M, Purdy JA, van Herk M, et al. ICRU Report 83. J ICRU 2010;10.","DOI":"10.1093\/jicru\/10.1.Report83"},{"key":"10.1016\/j.radonc.2022.09.015_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijrobp.2012.09.023","article-title":"RTOG 0529: A phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal","volume":"86","author":"Kachnic","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.09.015_b0055","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijrobp.2005.02.030","article-title":"Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: Toxicity and clinical outcome","volume":"63","author":"Milano","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.09.015_b0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.radonc.2022.03.014","article-title":"Online adaptive radiotherapy of urinary bladder cancer with full re-optimization to the anatomy of the day: Initial experience and dosimetric benefits: oART of bladder cancer: initial experience and dosimetric benefits","volume":"171","author":"\u00c5str\u00f6m","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2013.08.045","article-title":"Adaptive plan selection vs. re-optimisation in radiotherapy for bladder cancer: A dose accumulation comparison","volume":"109","author":"Vestergaard","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.phro.2022.04.009","article-title":"Cone-beam computed tomography-guided online adaptive radiotherapy is feasible for prostate cancer patients","volume":"22","author":"Zwart","year":"2022","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0075","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.13479","article-title":"Varian ethos online adaptive radiotherapy for prostate cancer: Early results of contouring accuracy, treatment plan quality, and treatment time","volume":"23","author":"Byrne","year":"2022","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.radonc.2022.09.015_b0080","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.radonc.2021.12.013","article-title":"Online adaptive radiotherapy potentially reduces toxicity for high-risk prostate cancer treatment","volume":"167","author":"Christiansen","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-020-01597-1","article-title":"Online adaptive radiotherapy compared to plan selection for rectal cancer: Quantifying the benefit","volume":"15","author":"De Jong","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-021-01866-7","article-title":"Feasibility of Conebeam CT-based online adaptive radiotherapy for neoadjuvant treatment of rectal cancer","volume":"16","author":"de Jong","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2020.09.024","article-title":"Online adaptive MR-guided radiotherapy for rectal cancer; feasibility of the workflow on a 1.5T MR-linac: clinical implementation and initial experience","volume":"154","author":"Intven","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0100","article-title":"Clinical implementation of artificial intelligence-driven cone-beam computed tomography-guided online adaptive radiotherapy in the pelvic region. Phys Imaging","volume":"17","author":"Sibolt","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0105","first-page":"77","article-title":"Making on-Line Adaptive Radiotherapy Possible Using Artificial Intelligence and Machine Learning for Efficient Daily Re-Planning","volume":"8","author":"Archambault","year":"2020","journal-title":"Med Phys Int J"},{"key":"10.1016\/j.radonc.2022.09.015_b0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tipsro.2022.04.001","article-title":"Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer","volume":"22","author":"Calmels","year":"2022","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.09.015_b0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijrobp.2009.05.071","article-title":"Radiation Dose-Volume Effects in the Stomach and Small Bowel","volume":"76","author":"Kavanagh","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.09.015_b0120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.clon.2014.09.016","article-title":"Defining bowel dose volume constraints for bladder radiotherapy treatment planning","volume":"27","author":"McDonald","year":"2015","journal-title":"Clin Oncol"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022044851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022044851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:23:12Z","timestamp":1759123392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814022044851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":24,"alternative-id":["S0167814022044851"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2022.09.015","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Online adaptive radiotherapy of anal cancer: Normal tissue sparing, target propagation methods, and first clinical experience","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2022.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}