{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:44:58Z","timestamp":1792759498010,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.radonc.2022.10.003","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T13:10:03Z","timestamp":1665753003000},"page":"21-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Systematic review for deep inspiration breath hold in proton therapy for mediastinal lymphoma: A PTCOG Lymphoma Subcommittee report and recommendations"],"prefix":"10.1016","volume":"177","author":[{"given":"Chirayu G.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Aznar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda D.","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna","family":"Pafundi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Flampouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranshu","family":"Mohindra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul R.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Mailhot Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Konig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Plastaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Loap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlia M.","family":"Kirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"L\u00fctgendorf-Caucig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Ntentas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford","family":"Hoppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2022.10.003_b0005","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.ijrobp.2006.11.008","article-title":"Active breathing control for Hodgkin\u2019s disease in childhood and adolescence: feasibility, advantages, and limits","volume":"67","author":"Claude","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0010","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1200\/JCO.20.00264","article-title":"Cause-specific mortality following initial chemotherapy in a population-based cohort of patients with classical hodgkin lymphoma, 2000\u20132016","volume":"38","author":"Dores","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1200\/JCO.2015.63.4444","article-title":"Radiation dose-response relationship for risk of coronary heart disease in survivors of Hodgkin Lymphoma","volume":"34","author":"van Nimwegen","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0020","article-title":"Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines","author":"van Nimwegen","year":"2017","journal-title":"Published online"},{"key":"10.1016\/j.radonc.2022.10.003_b0025","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijrobp.2017.09.048","article-title":"Reduced mortality risk in the recent era in early-stage hodgkin lymphoma patients treated with radiation therapy with or without chemotherapy","volume":"100","author":"Patel","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0030","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1182\/blood-2002-02-0634","article-title":"Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors","volume":"100","author":"Ng","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.radonc.2022.10.003_b0035","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1200\/JCO.2002.08.021","article-title":"Long-term survival and competing causes of death in patients with early-stage Hodgkin \u2019 s disease treated at age 50 or younger conclusion : patients","volume":"20","author":"Ng","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0040","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ijrobp.2018.03.003","article-title":"Predictors of hypothyroidism in Hodgkin lymphoma survivors after intensity-modulated versus 3-dimensional radiation therapy HHS public access","volume":"101","author":"Pinnix","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0045","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.ijrobp.2021.06.030","article-title":"Clinical outcomes confirm conjecture: modern radiation therapy reduces the risk of late toxicity in survivors of Hodgkin lymphoma","volume":"111","author":"Milgrom","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0050","unstructured":"Kumar A, Casulo C, Advani RH, et al. Brentuximab Vedotin Combined With Chemotherapy in Patients With Newly Diagnosed Early-Stage, Unfavorable-Risk Hodgkin Lymphoma. Vol 39.; 2021. https:\/\/doi.org\/10."},{"key":"10.1016\/j.radonc.2022.10.003_b0055","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1748-717X-9-94","article-title":"Dosimetric advantages of a \u201cbutterfly\u201d technique for intensity-modulated radiation therapy for young female patients with mediastinal Hodgkin\u2019s lymphoma","volume":"9","author":"Voong","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0060","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ijrobp.2009.11.013","article-title":"Radiation for Hodgkin\u2019s lymphoma in young female patients: a new technique to avoid the breasts and decrease the dose to the heart","volume":"79","author":"Dabaja","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0065","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ijrobp.2015.11.049","article-title":"Deep inspiration breath hold - based radiation therapy: a clinical review","volume":"94","author":"Boda-Heggemann","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0070","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.ijrobp.2011.05.015","article-title":"Dosimetric benefits of intensity-modulated radiotherapy combined with the deep-inspiration breath-hold technique in patients with mediastinal Hodgkin\u2019s lymphoma","volume":"82","author":"Paumier","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0075","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0360-3016(00)00681-7","article-title":"Active breathing control (ABC) for Hodgkin\u2019s disease: reduction in normal tissue irradiation with deep inspiration and implications for treatment","volume":"48","author":"Stromberg","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0080","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijrobp.2010.09.007","article-title":"Involved-node radiotherapy and modern radiation treatment techniques in patients with Hodgkin lymphoma","volume":"80","author":"Paumier","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0085","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.prro.2013.07.015","article-title":"Active breathing control for patients receiving mediastinal radiation therapy for lymphoma: impact on normal tissue dose","volume":"4","author":"Charpentier","year":"2014","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijrobp.2015.01.013","article-title":"Minimizing late effects for patients with mediastinal Hodgkin lymphoma: deep inspiration breath-hold, IMRT, or both?","volume":"92","author":"Aznar","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0095","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.radonc.2018.08.017","article-title":"Comparison of butterfly volumetric modulated arc therapy to full arc with or without deep inspiration breath hold for the treatment of mediastinal lymphoma","volume":"129","author":"Starke","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.radonc.2017.07.033","article-title":"Life years lost attributable to late effects after radiotherapy for early stage Hodgkin lymphoma: the impact of proton therapy and\/or deep inspiration breath hold","volume":"125","author":"Rechner","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-018-1066-2","article-title":"Proton versus photon deep inspiration breath hold technique in patients with hodgkin lymphoma and mediastinal radiation","volume":"13","author":"Baues","year":"2018","journal-title":"Radiation Oncology"},{"key":"10.1016\/j.radonc.2022.10.003_b0110","doi-asserted-by":"crossref","unstructured":"Ricardi U, Maraldo M v., Levis M, Parikh RR. Proton therapy for lymphomas: Current state of the art. Onco Targets Ther. 2019;12:8033-8046. doi:10.2147\/OTT.S220730.","DOI":"10.2147\/OTT.S220730"},{"key":"10.1016\/j.radonc.2022.10.003_b0115","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.ijrobp.2008.12.048","article-title":"Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin\u2019s lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy","volume":"75","author":"Chera","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0120","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/annonc\/mdx287","article-title":"Consolidative proton therapy after chemotherapy for patients with Hodgkin lymphoma","volume":"28","author":"Hoppe","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0125","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2011.12.034","article-title":"Effective dose reduction to cardiac structures using protons compared with 3DCRT and IMRT in mediastinal Hodgkin lymphoma","volume":"84","author":"Hoppe","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0130","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ijrobp.2017.05.004","article-title":"Critical review evidence-based review on the use of proton therapy in lymphoma from the particle therapy cooperative group (PTCOG) lymphoma subcommittee radiation oncology","volume":"99","author":"Tseng","year":"2017","journal-title":"Int J Radiation Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0135","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.prro.2019.05.009","article-title":"Comparison of techniques for involved-site radiation therapy in patients with lower mediastinal lymphoma","volume":"9","author":"Everett","year":"2019","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/0284186X.2018.1512153","article-title":"Comparative treatment planning study for mediastinal Hodgkin\u2019s lymphoma: impact on normal tissue dose using deep inspiration breath hold proton and photon therapy","volume":"58","author":"Edvardsson","year":"2019","journal-title":"Acta Oncol (Madr)"},{"key":"10.1016\/j.radonc.2022.10.003_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-019-1432-8","article-title":"Comparative photon and proton dosimetry for patients with mediastinal lymphoma in the era of Monte Carlo treatment planning and variable relative biological effectiveness","volume":"14","author":"Tseng","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0150","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.adro.2020.08.004","article-title":"Effect of deep inspiration breath hold on normal tissue sparing with intensity modulated radiation therapy versus proton therapy for mediastinal lymphoma","volume":"5","author":"Moreno","year":"2020","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0155","doi-asserted-by":"crossref","unstructured":"Taparra K, Lester SC, Harmsen WS, et al. Reducing Heart Dose with Protons and Cardiac Substructure Sparing for Mediastinal Lymphoma Treatment. 2020;(July):1-13. doi:10.14338\/IJPT-20-00010.1.","DOI":"10.14338\/IJPT-20-00010.1"},{"key":"10.1016\/j.radonc.2022.10.003_b0160","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.prro.2019.01.006","article-title":"Clinical intensity modulated proton therapy for hodgkin lymphoma: which patients benefit the most?","volume":"9","author":"Ntentas","year":"2019","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0165","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/ptj\/89.9.873","article-title":"Reprint - preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"89","author":"Moher","year":"2009","journal-title":"Phys Ther"},{"key":"10.1016\/j.radonc.2022.10.003_b0170","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ijrobp.2013.05.005","article-title":"Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the international lymphoma radiation oncology group (ILROG)","volume":"89","author":"Specht","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2020.03.019","article-title":"Involved site radiation therapy in adult lymphomas: an overview of international lymphoma radiation oncology group guidelines","author":"Wirth","year":"2020","journal-title":"Int J Radiat Oncol*Biol*Phys Published online"},{"key":"10.1016\/j.radonc.2022.10.003_b0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijrobp.2015.02.010","article-title":"Predictors of radiation pneumonitis in patients receiving intensity modulated radiation therapy for Hodgkin and non-hodgkin lymphoma","volume":"92","author":"Pinnix","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0185","first-page":"10","article-title":"Secondary malignancy risk following proton vs. X-ray treatment of mediastinal malignant lymphoma: a comparative modeling study of thoracic organ-specific cancer risk","author":"K\u00f6nig","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.radonc.2022.10.003_b0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijrobp.2017.05.014","article-title":"Consensus guidelines for implementing pencil-beam scanning proton therapy for thoracic malignancies on behalf of the PTCOG thoracic and lymphoma subcommittee","volume":"99","author":"Chang","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.10.003_b0195","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1088\/0031-9155\/54\/22\/007","article-title":"Using surface imaging and visual coaching to improve the reproducibility and stability of deep-inspiration breath hold for left-breast-cancer radiotherapy","volume":"54","author":"Cervi\u00f1o","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2022.10.003_b0200","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1182\/blood-2018-03-837633","article-title":"Proton therapy for adults with mediastinal lymphomas: the international lymphoma radiation oncology group guidelines","volume":"132","author":"Dabaja","year":"2018","journal-title":"Blood"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022044978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022044978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:22:01Z","timestamp":1759123321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814022044978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":40,"alternative-id":["S0167814022044978"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2022.10.003","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic review for deep inspiration breath hold in proton therapy for mediastinal lymphoma: A PTCOG Lymphoma Subcommittee report and recommendations","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2022.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}