{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:03:41Z","timestamp":1785539021882,"version":"3.56.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005945","name":"Hirosaki University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K16814"],"award-info":[{"award-number":["20K16814"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["2020-047"],"award-info":[{"award-number":["2020-047"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thegreenjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Radiotherapy and Oncology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.radonc.2022.109444","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T20:12:07Z","timestamp":1676405527000},"page":"109444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Translational study for stereotactic body radiotherapy against non-small cell lung cancer, including oligometastases, considering cancer stem-like cells enable predicting clinical outcome from in vitro data"],"prefix":"10.1016","volume":"181","author":[{"given":"Ryo","family":"Saga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Matsuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Obara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Komai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.radonc.2022.109444_b0005","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1200\/JCO.2006.07.5937","article-title":"Excessive toxicity when treating central tumors in a phase \u2161 study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer","volume":"24","author":"Timmerman","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0010","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.ijrobp.2005.05.034","article-title":"Clinical outcomes of a phase \u2160\/\u2161 study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame","volume":"63","author":"Nagata","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13014-016-0581-2","article-title":"Clinical outcome of stereotactic body radiotherapy for primary and oligometastatic lung tumors: a single institutional study with almost uniform dose with different five treatment schedules","volume":"11","author":"Aoki","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0020","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijrobp.2009.02.087","article-title":"Survey of stereotactic body radiation therapy in Japan by the Japan 3-D conformal external beam radiotherapy group","volume":"75","author":"Nagata","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0025","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1259\/bjr\/31372149","article-title":"21 years of biologically effective dose","volume":"83","author":"Fowler","year":"2010","journal-title":"Br J Radiol"},{"key":"10.1016\/j.radonc.2022.109444_b0030","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0360-3016(00)00571-X","article-title":"Biological equivalent dose assessment of the consequences of hypofractionated radiotherapy","volume":"47","author":"Jones","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0035","unstructured":"E. J. Hall, A. J. Giaccia (eds.). Time, dose, and fractionation in radiotherapy. In: Radiobiology for the Radiologist, 6th edn. Philadelphia: Lippincott Williams & Wilkins; 2006:378\u2013379."},{"key":"10.1016\/j.radonc.2022.109444_b0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.radonc.2013.09.005","article-title":"Applicability of the linear-quadratic formalism for modeling local tumor control probability in high dose per fraction stereotactic body radiotherapy for early stage non-small cell lung cancer","volume":"109","author":"Guckenberger","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1269\/jrr.11095","article-title":"Radiobiological evaluation of the radiation dose as used in high-precision radiotherapy: effect of prolonged delivery time and applicability of the linear-quadratic model","volume":"53","author":"Shibamoto","year":"2012","journal-title":"J Radiat Res"},{"key":"10.1016\/j.radonc.2022.109444_b0050","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ijrobp.2008.12.093","article-title":"Estimation of errors associated with use of linear-quadratic formalism for evaluation of biologic equivalence between single and hypofractionated radiation doses: an in vitro study","volume":"75","author":"Iwata","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0055","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.ijrobp.2011.05.034","article-title":"Compatibility of the linear-quadratic formalism and biologically effective dose concept to high-dose-per-fraction irradiation in a murine tumor","volume":"81","author":"Otsuka","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0060","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1118\/1.2969065","article-title":"Some implications of linear-quadratic-linear radiation dose-response with regard to hypofractionation","volume":"35","author":"Astrahan","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0065","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ijrobp.2007.10.059","article-title":"Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy","volume":"70","author":"Park","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0070","doi-asserted-by":"crossref","first-page":"39ra48","DOI":"10.1126\/scitranslmed.3000864","article-title":"A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapy","volume":"2","author":"Wang","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.radonc.2022.109444_b0075","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1097\/JTO.0b013e318074de34","article-title":"Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study","volume":"2","author":"Onishi","year":"2007","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0080","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0360-3016(02)02949-8","article-title":"Preclinical biological assessment of proton and carbon ion beams at hyogo ion beam medical center","volume":"54","author":"Kagawa","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0085","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0360-3016(86)90071-4","article-title":"Distribution of radiation sensitivities for human tumor cells of specific histological types: comparison of in vitro to in vivo data","volume":"12","author":"Malaise","year":"1986","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0090","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/B978-0-12-035405-4.50012-8","article-title":"The four R\u2019s of radiotherapy","volume":"5","author":"Withers","year":"1975","journal-title":"Adv Radiat Biol"},{"key":"10.1016\/j.radonc.2022.109444_b0095","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1118\/1.2229427","article-title":"Effects of oxygen on intrinsic radiation sensitivity: a test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parameters","volume":"33","author":"Carlson","year":"2006","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0100","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0360-3016(95)00544-9","article-title":"A convenient extension of the linear-quadratic model to include redistribution and reoxygenation","volume":"32","author":"Brenner","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1063\/1.3225276","article-title":"Repopulation kinetics and the linear-quadratic model","volume":"1148","author":"O\u2019Rourke","year":"2009","journal-title":"AIP Conf Proc"},{"key":"10.1016\/j.radonc.2022.109444_b0110","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/09553008914552491","article-title":"The 5Rs of radiobiology","volume":"56","author":"Steel","year":"1989","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.radonc.2022.109444_b0115","doi-asserted-by":"crossref","unstructured":"J. C. L. Alfonso, L. Berk. Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy. 14, 88 (2019)","DOI":"10.1186\/s13014-019-1288-y"},{"key":"10.1016\/j.radonc.2022.109444_b0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/0471141755.ph1425s61","article-title":"Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy","volume":"61","author":"Bao","year":"2013","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.radonc.2022.109444_b0125","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jrr\/rrz011","article-title":"Analysis of the high dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model","volume":"60","author":"Saga","year":"2019","journal-title":"J Radiat Res"},{"key":"10.1016\/j.radonc.2022.109444_b0130","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/s41598-022-05172-4","article-title":"Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability","volume":"12","author":"Fukui","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.radonc.2022.109444_b0135","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fphys.2013.00212","article-title":"Ionizing radiation, ion transports, and radioresistance of cancer cells","volume":"4","author":"Huber","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.radonc.2022.109444_b0140","first-page":"292","article-title":"Does ionizing radiation stimulate cancer invasion and metastasis?","volume":"95","author":"Madani","year":"2008","journal-title":"Bull Cancer"},{"key":"10.1016\/j.radonc.2022.109444_b0145","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10555-016-9616-2","article-title":"Risk of second cancers in the era of modern radiation therapy: does the risk\/benefit analysis overcome theoretical models?","volume":"35","author":"Chargari","year":"2016","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.radonc.2022.109444_b0150","first-page":"51","article-title":"Radiation induces epithelial-mesenchymal transition in colorectal cancer cells","volume":"27","author":"Kawamoto","year":"2012","journal-title":"Oncol Rep"},{"key":"10.1016\/j.radonc.2022.109444_b0155","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1038\/s41598-018-26556-5","article-title":"Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates","volume":"8","author":"Matsuya","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.radonc.2022.109444_b0160","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.1038\/s41598-019-45960-z","article-title":"Intensity modulated radiation fields induce protective effects and reduce importance of dose-rate effects","volume":"9","author":"Matsuya","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.radonc.2022.109444_b0165","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab7d14","article-title":"A theoretical cell-killing model to evaluate oxygen enhancement ratios at DNA damage and cell survival endpoints in radiation therapy","volume":"65","author":"Matsuya","year":"2020","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2022.109444_b0170","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/cells9051117","article-title":"A model for estimating dose-rate effects on cell-killing of human melanoma after boron neutron capture therapy","volume":"9","author":"Matsuya","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.radonc.2022.109444_b0175","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.semradonc.2008.04.004","article-title":"The linear\u2013quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction","volume":"18","author":"Brenner","year":"2008","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0180","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3892\/ol.2022.13199","article-title":"Identification of novel prognostic factors focusing on clinical outcomes in patients with non-small cell lung cancer sfter stereotactic body radiotherapy","volume":"23","author":"Sato","year":"2022","journal-title":"Oncol Lett"},{"key":"10.1016\/j.radonc.2022.109444_b0185","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1088\/0031-9155\/38\/6\/001","article-title":"A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density","volume":"38","author":"Webb","year":"1993","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.radonc.2022.109444_b0190","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1667\/RR14681.1","article-title":"A microdosimetric-kinetic model of cell killing by irradiation from permanently incorporated radionuclides","volume":"189","author":"Hawkins","year":"2018","journal-title":"Radiat Res"},{"key":"10.1016\/j.radonc.2022.109444_b0195","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1080\/00223131.2017.1419890","article-title":"Features of particle and heavy ion transport code system (PHITS) version 3.02","volume":"55","author":"Sato","year":"2018","journal-title":"J Nucl Sci Technol"},{"key":"10.1016\/j.radonc.2022.109444_b0200","doi-asserted-by":"crossref","unstructured":"H. Hirayama, Y. Namito, A. F. Bielajew, S. J. Wilderman, and W. R. Nelson, The EGS5 Code System; Office of Scientific and Technical Information (OSTI): Oak Ridge, TN, 2005.","DOI":"10.2172\/877459"},{"key":"10.1016\/j.radonc.2022.109444_b0205","series-title":"Report 36. International Commission on Radiation Units and Measurements","author":"Microdosimetry","year":"1983"},{"key":"10.1016\/j.radonc.2022.109444_b0210","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.nimb.2007.09.039","article-title":"Ionization and excitation collision processes of electrons in liquid water","volume":"265","author":"Date","year":"2007","journal-title":"Nucl Instrum Methods Phys Res Sect B"},{"key":"10.1016\/j.radonc.2022.109444_b0220","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2482\/haigan.25.55","article-title":"Evaluation of therapeutic effects on lung cancer \u2013 comparison of actual survival to survival predicted by actual tumor volume doubling time and tumor diameter on first observation","volume":"25z81","author":"Mizuno","year":"1985","journal-title":"Jpn J Lung Cancer"},{"key":"10.1016\/j.radonc.2022.109444_b0225","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1002\/mp.12508","article-title":"Markov chain Monte Carlo analysis for the selection of a cell-killing model under high-dose rate irradiation","volume":"44","author":"Matsuya","year":"2017","journal-title":"Med Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0230","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/JTO.0b013e318257cc89","article-title":"C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small cell lung cancer cells with radiation-induced c-Met-expression","volume":"7","author":"Bhardwaj","year":"2012","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0245","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.ijrobp.2018.07.2009","article-title":"Tumor control probability analysis for single-fraction carbon-ion radiation therapy of early-stage non-small cell lung cancer","volume":"102","author":"Paz","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0250","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ijrobp.2005.09.043","article-title":"Examination of GyE system for HIMAC carbon therapy","volume":"64","author":"Kanai","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0255","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ijrobp.2020.08.014","article-title":"Tumor control probability modeling and systematic review of the literature of stereotactic body radiation therapy for prostate cancer","volume":"110","author":"Royce","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.radonc.2022.109444_b0260","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijrobp.2020.05.062","article-title":"Modeling of tumor control probability in stereotactic body radiation therapy for adrenal tumors","volume":"110","author":"Stumpf","year":"2021","journal-title":"Int J Radiat Oncol Biol"},{"key":"10.1016\/j.radonc.2022.109444_b0265","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0167-8140(02)00367-5","article-title":"Carbon ion radiotherapy for stage \u2160 non-small cell lung cancer","volume":"66","author":"Miyamoto","year":"2003","journal-title":"Radither Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0270","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1088\/0031-9155\/60\/8\/3271","article-title":"Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences","volume":"60","author":"Inaniwa","year":"2015","journal-title":"Japan Phys Med Biol"},{"key":"10.1016\/j.radonc.2022.109444_b0275","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4252\/wjsc.v7.i9.1150","article-title":"Common stemness regulators of embryonic and cancer stem cells","volume":"7","author":"Hadjimichael","year":"2015","journal-title":"World J Stem Cells"},{"key":"10.1016\/j.radonc.2022.109444_b0280","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12032-014-0069-6","article-title":"Cancer stem cell detection and isolation","volume":"31","author":"Moghbeli","year":"2014","journal-title":"Med Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12943-017-0600-4","article-title":"Intra-tumor heterogeneity from a cancer stem cell perspective","volume":"16","author":"Prasetyanti","year":"2017","journal-title":"Mol Cancer"},{"key":"10.1016\/j.radonc.2022.109444_b0290","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrc3184","article-title":"Cancer stem cells: an evolving concept","volume":"12","author":"Nguyen","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.radonc.2022.109444_b0295","doi-asserted-by":"crossref","first-page":"e96093","DOI":"10.1371\/journal.pone.0096093","article-title":"Tumor control probability in cancer stem cells hypothesis","volume":"9","author":"Dhawan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.radonc.2022.109444_b0300","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1186\/1471-2407-14-464","article-title":"Outcomes after stereotactic body radiotherapy for lung tumors, with emphasis on comparison of primary lung cancer and metastatic lung tumors","volume":"14","author":"Yamamoto","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.radonc.2022.109444_b0305","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.radonc.2017.03.014","article-title":"Radiobiological parameters of liver and lung metastases derived from tumor control data of 3719 metastases","volume":"123","author":"Klement","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0310","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2016.11.006","article-title":"Tumor control probability modeling for stereotactic body radiation therapy of early-stage lung cancer using multiple bio-physical models","volume":"122","author":"Liu","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.radonc.2022.109444_b0315","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/jrr\/rraa027","article-title":"Stereotactic body radiation therapy for early-stage non-small-cell lung cancer in octogenarians and older: an alternative treatment","volume":"61","author":"Bei","year":"2020","journal-title":"J Radiat Res"}],"container-title":["Radiotherapy and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022045935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167814022045935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:20:07Z","timestamp":1777504807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167814022045935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":60,"alternative-id":["S0167814022045935"],"URL":"https:\/\/doi.org\/10.1016\/j.radonc.2022.109444","relation":{},"ISSN":["0167-8140"],"issn-type":[{"value":"0167-8140","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translational study for stereotactic body radiotherapy against non-small cell lung cancer, including oligometastases, considering cancer stem-like cells enable predicting clinical outcome from in vitro data","name":"articletitle","label":"Article Title"},{"value":"Radiotherapy and Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.radonc.2022.109444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109444"}}